SUMMARYInvestigation of Antidepressant Drug Treatment Effect on PolymorphonuclearLeukocyte Functions of Patients With Major DepressionIn this study our aim was to investigate the effect of antidepressant drugs onpolymorphonuclear leukocyte functions, serum folic acid, vitamin B12, cortisol, zinc,copper levels and hemogram parameters of patients (n=12 average age 40) with MajorDepression.PMNs ( 1 X 107 cell /ml) were isolated by ficoll-hypaque gradient centrifugationmethod from venous blood with EDTA. Phagocytosis and intracellular killing activitywere assayed by modifying Alexander?s method (1968)The phagocytic activity of PMN of MD patients was found in the same level ashealthy volunteers (n=10, averadge age 35), the intracellular killing activity was foundlower than that of healthy volunteers.The PMN?s phagocytic activity of patients with Major Depression after 2 monthsof antidepressant drug treatment unsignificantly increased when compared with thosebefore treatment. The intracellular killing activity was not effected (p>0,05).Within the reference values, as the level of folic acid unsignificantly, level ofcortisol significantly increased, the levels of vitamin B12, zinc unsignificantly decreased,level of copper was not effected.After 2 months of treatment EO% value, PLT counts when compared with thosebefore treatment, WBC, NE, PLT counts, EO% values when compared with those after 1months of treatment significantly increased. (p<0,05) Other hematological parametersunsignificantly changed within reference values.In conclusion, we found that antidepressant drugs increased the phagocyticactivity of PMNs, did not effect the intracellular killing activity, within reference valueschanged the parameters we studied on.Key words: Antidepressant, depression, PMN, phagocytosis, zinc.

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