Association between caffeine intake and liver biomarkers in non-alcoholic fatty liver disease

Kübra Uçar; Evrim Kahramanoğlu; Zeynep Göktaş

Makale detayları

Association between caffeine intake and liver biomarkers in non-alcoholic fatty liver disease

Yazarlar:

Kübra Uçar | Evrim Kahramanoğlu | Zeynep Göktaş

Yayıncı:

Cukurova University

Ana Başlıklar:

Klinik Tıp Bilimleri

Dergi:

Cukurova Medical Journal Vol.48 Issue 1, pp.177-186

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001282225

pISSN:

2602-3032

Anahtar kelimeler:

Özet:

 Purpose: Non-alcoholic fatty liver disease NAFLD is the most common cause of elevated liver enzymes in developed countries. The aim of this study is to examine the effects of caffeine intake on some parameters of liver metabolism in individuals with NAFLD. Materials and Methods: A total of 20 female and 20 male subjects between the ages of 19 to 64, who were diagnosed with NAFLD, were included in the study. To determine caffeine intake, a specially developed caffeine-food frequency questionnaire was administered by a trained dietitian. Individuals were categorized into 3 groups according to their caffeine intake; Group 1: 150 mgday, Group 2: 150-250 mgday, and Group 3: 250 mgday. Anthropometric measurements and biochemical parameters were recorded. Protein quantities in serum samples were determined by ELISA method. Results: The body fat composition of group 1 was higher than group 2. Alanine aminotransferase ALT and aspartate aminotransferase AST levels of group 3 were higher than group 1 and group 2, respectively. High-density lipoprotein cholesterol HDL-C level of group 3 was lower than group 1 and group 2. There was a positive correlation between total caffeine intake and ALT level. There was no significant difference between the caffeine intake groups in terms of serum protein levels. In addition, there was not found significant correlation between serum protein levels and total caffeine intake. Conclusion: Caffeine intake of 250 mgday may increase ALT and AST levels and decrease HDL-C level in individuals with NAFLD.

 Purpose: Non-alcoholic fatty liver disease NAFLD is the most common cause of elevated liver enzymes in developed countries. The aim of this study is to examine the effects of caffeine intake on some parameters of liver metabolism in individuals with NAFLD. Materials and Methods: A total of 20 female and 20 male subjects between the ages of 19 to 64, who were diagnosed with NAFLD, were included in the study. To determine caffeine intake, a specially developed caffeine-food frequency questionnaire was administered by a trained dietitian. Individuals were categorized into 3 groups according to their caffeine intake; Group 1: 150 mgday, Group 2: 150-250 mgday, and Group 3: 250 mgday. Anthropometric measurements and biochemical parameters were recorded. Protein quantities in serum samples were determined by ELISA method. Results: The body fat composition of group 1 was higher than group 2. Alanine aminotransferase ALT and aspartate aminotransferase AST levels of group 3 were higher than group 1 and group 2, respectively. High-density lipoprotein cholesterol HDL-C level of group 3 was lower than group 1 and group 2. There was a positive correlation between total caffeine intake and ALT level. There was no significant difference between the caffeine intake groups in terms of serum protein levels. In addition, there was not found significant correlation between serum protein levels and total caffeine intake. Conclusion: Caffeine intake of 250 mgday may increase ALT and AST levels and decrease HDL-C level in individuals with NAFLD.

 Purpose: Non-alcoholic fatty liver disease NAFLD is the most common cause of elevated liver enzymes in developed countries. The aim of this study is to examine the effects of caffeine intake on some parameters of liver metabolism in individuals with NAFLD. Materials and Methods: A total of 20 female and 20 male subjects between the ages of 19 to 64, who were diagnosed with NAFLD, were included in the study. To determine caffeine intake, a specially developed caffeine-food frequency questionnaire was administered by a trained dietitian. Individuals were categorized into 3 groups according to their caffeine intake; Group 1: 150 mgday, Group 2: 150-250 mgday, and Group 3: 250 mgday. Anthropometric measurements and biochemical parameters were recorded. Protein quantities in serum samples were determined by ELISA method. Results: The body fat composition of group 1 was higher than group 2. Alanine aminotransferase ALT and aspartate aminotransferase AST levels of group 3 were higher than group 1 and group 2, respectively. High-density lipoprotein cholesterol HDL-C level of group 3 was lower than group 1 and group 2. There was a positive correlation between total caffeine intake and ALT level. There was no significant difference between the caffeine intake groups in terms of serum protein levels. In addition, there was not found significant correlation between serum protein levels and total caffeine intake. Conclusion: Caffeine intake of 250 mgday may increase ALT and AST levels and decrease HDL-C level in individuals with NAFLD.

 Amaç: Non-alkolik yağlı karaciğer hastalığı NAFLD, gelişmiş ülkelerde karaciğer enzimlerindeki yükselmenin en yaygın nedenidir. Bu çalışmanın amacı, NAFLD olan bireylerde kafein alımının karaciğer metabolizmasının bazı parametreleri üzerindeki etkilerini incelemektir. Gereç ve Yöntem: Çalışmaya NAFLD tanısı almış 19-64 yaş arasında toplam 20 kadın ve 20 erkek birey dahil edilmiştir. Kafein alımını belirlemek için, deneyimli bir diyetisyen tarafından özel olarak geliştirilmiş kafein-besin alım sıklığı anketi uygulanmıştır. Bireyler kafein alımlarına göre 3 gruba ayrılmıştır; Grup 1: 150 mggün, Grup 2: 150-250 mggün ve Grup 3: 250 mggün. Antropometrik ölçümler ve biyokimyasal parametreler kaydedilmiştir. Serum örneklerindeki protein miktarları ELISA yöntemi ile belirlenmiştir. Bulgular: Grup 1in vücut yağ kompozisyonu grup 2den daha yüksektir. Grup 3ün alanin aminotransferaz ALT ve aspartat aminotransferaz AST düzeyleri sırasıyla grup 1den ve grup 2den daha yüksektir. Grup 3ün yüksek yoğunluklu lipoprotein kolesterol HDL-C düzeyi grup 1 ve grup 2den daha düşüktür. Toplam kafein alımı ile ALT düzeyi arasında pozitif bir ilişki vardır. Kafein alım grupları arasında serum protein düzeyleri açısından anlamlı bir farklılık yoktur. Ayrıca serum protein seviyeleri ile toplam kafein alımı arasında anlamlı bir korelasyon bulunmamıştır. Sonuç: 250 mggün kafein alımı, NAYKH olan bireylerde ALT ve AST düzeylerini yükseltebilir ve HDL-C düzeyini düşürebilir.

Makale detayları

Association between caffeine intake and liver biomarkers in non-alcoholic fatty liver disease

Yazarlar:

Kübra Uçar | Evrim Kahramanoğlu | Zeynep Göktaş

Yayıncı:

Cukurova University

Ana Başlıklar:

Klinik Tıp Bilimleri

Dergi:

Cukurova Medical Journal Vol.48 Issue 1, pp.177-186

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001282225

pISSN:

2602-3032

Non-alcoholic fatty liver disease

caffeine

alanine aminotransferase

aspartate aminotransferase

high-density lipoprotein

Non-alkolik yağlı karaciğer hastalığı

kafein

alanin aminotransferaz

aspartat aminotransferaz

yüksek yoğunluklu lipoprotein

Sayı

Makale detayları

Yazarlar: Kübra Uçar | Evrim Kahramanoğlu | Zeynep Göktaş

Yayıncı: Cukurova University

Ana Başlıklar: Klinik Tıp Bilimleri

Dergi: Cukurova Medical Journal Vol.48 Issue 1, pp.177-186

Belge Tipi: Makale

Yayın Tarihi: 3/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001282225

pISSN: 2602-3032

Sayı

Yazarlar:

Kübra Uçar | Evrim Kahramanoğlu | Zeynep Göktaş

Yayıncı:

Cukurova University

Ana Başlıklar:

Klinik Tıp Bilimleri

Dergi:

Cukurova Medical Journal Vol.48 Issue 1, pp.177-186

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001282225

pISSN:

2602-3032