25-Hydroxyvitamin D Status In Type 1 Diabetic Adults And Its Relationship With Glycemic Control

Burak Andaç; Buket Yılmaz Bülbül; Mehmet Oğulcan Tezel; Mine Okur; Serpil Yanık Çolak; Buse Ekici; Mehmet Celik

Makale detayları

25-Hydroxyvitamin D Status In Type 1 Diabetic Adults And Its Relationship With Glycemic Control

Yazarlar:

Burak Andaç | Buket Yılmaz Bülbül | Mehmet Oğulcan Tezel | Mine Okur | Serpil Yanık Çolak | Buse Ekici | Mehmet Celik

Yayıncı:

Akdeniz University

Ana Başlıklar:

Klinik Tıp Bilimleri

Dergi:

Akdeniz Tıp Dergisi Vol.10 Issue 2, pp.284-288

Belge Tipi:

Makale

Yayın Tarihi:

1/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001317191

pISSN:

2687-2781

Anahtar kelimeler:

Özet:

 Objective: To assess the vitamin D levels between adults with type 1 diabetes mellitus and the healthy control group and evaluate the relationship between HbA1c levels and vitamin D status in the diabetic group. Methods: Our cross-sectional, descriptive study included 98 type 1 diabetic patients over 18 years old who applied to the Endocrinology Outpatient Clinic and 95 age- and sex-matched individuals without chronic disease. Patients with advanced renal or liver disorders, primary hyperparathyroidism, metabolic bone disorders, or using medications that might change vitamin D concentrations were excluded from the study. HbA1c and 25OH Vitamin-D3 levels were measured three times in 9 months, and the average of the measurements was used. Diabetic patients and control individuals were separated into three groups according to their vitamin D levels as follows: deficiency 12 ngml, insufficiency 12-20 ngml, and sufficiency  20 ngml. Results: Serum 25 OH vitamin D levels of diabetic patients were significantly lower than in healthy individuals p0.024. However, when diabetic adults were separated into three groups according to 25OH vitamin D levels, there was no significant difference regarding HbA1c levels p0.905. Conclusion: Although preclinical data support the role of low serum vitamin D levels in the etiopathogenesis of type 1 diabetes mellitus, studies examining the connection between low serum vitamin D levels and the prevalence of type 1 diabetes or glycemic control are not sufficient to reach a clear conclusion, including our study.

 Objective: To assess the vitamin D levels between adults with type 1 diabetes mellitus and the healthy control group and evaluate the relationship between HbA1c levels and vitamin D status in the diabetic group. Methods: Our cross-sectional, descriptive study included 98 type 1 diabetic patients over 18 years old who applied to the Endocrinology Outpatient Clinic and 95 age- and sex-matched individuals without chronic disease. Patients with advanced renal or liver disorders, primary hyperparathyroidism, metabolic bone disorders, or using medications that might change vitamin D concentrations were excluded from the study. HbA1c and 25OH Vitamin-D3 levels were measured three times in 9 months, and the average of the measurements was used. Diabetic patients and control individuals were separated into three groups according to their vitamin D levels as follows: deficiency 12 ngml, insufficiency 12-20 ngml, and sufficiency  20 ngml. Results: Serum 25 OH vitamin D levels of diabetic patients were significantly lower than in healthy individuals p0.024. However, when diabetic adults were separated into three groups according to 25OH vitamin D levels, there was no significant difference regarding HbA1c levels p0.905. Conclusion: Although preclinical data support the role of low serum vitamin D levels in the etiopathogenesis of type 1 diabetes mellitus, studies examining the connection between low serum vitamin D levels and the prevalence of type 1 diabetes or glycemic control are not sufficient to reach a clear conclusion, including our study.

 Objective: To assess the vitamin D levels between adults with type 1 diabetes mellitus and the healthy control group and evaluate the relationship between HbA1c levels and vitamin D status in the diabetic group. Methods: Our cross-sectional, descriptive study included 98 type 1 diabetic patients over 18 years old who applied to the Endocrinology Outpatient Clinic and 95 age- and sex-matched individuals without chronic disease. Patients with advanced renal or liver disorders, primary hyperparathyroidism, metabolic bone disorders, or using medications that might change vitamin D concentrations were excluded from the study. HbA1c and 25OH Vitamin-D3 levels were measured three times in 9 months, and the average of the measurements was used. Diabetic patients and control individuals were separated into three groups according to their vitamin D levels as follows: deficiency 12 ngml, insufficiency 12-20 ngml, and sufficiency  20 ngml. Results: Serum 25 OH vitamin D levels of diabetic patients were significantly lower than in healthy individuals p0.024. However, when diabetic adults were separated into three groups according to 25OH vitamin D levels, there was no significant difference regarding HbA1c levels p0.905. Conclusion: Although preclinical data support the role of low serum vitamin D levels in the etiopathogenesis of type 1 diabetes mellitus, studies examining the connection between low serum vitamin D levels and the prevalence of type 1 diabetes or glycemic control are not sufficient to reach a clear conclusion, including our study.

 Amaç: Tip 1 diabetes mellituslu erişkinler ile sağlıklı kontrol grubu arasında D vitamini düzeylerini karşılaştırmak ve diyabetik grupta HbA1c ile D vitamini düzeyleri arasındaki ilişkiyi değerlendirmek amaçlanmıştır. Yöntemler: Kesitsel, tanımlayıcı tipteki çalışmamıza Endokrinoloji Polikliniğine başvuran 18 yaş üstü, 98 tip 1 diyabetli hasta ile yaş ve cinsiyet olarak eşleştirilmiş, kronik hastalığı olmayan 95 kişi dahil edildi. İleri derecede böbrek veya karaciğer hastalığı, primer hiperparatiroidizmi, metabolik kemik hastalığı olan veya vitamin D konsantrasyonlarını değiştirebilecek ilaç kullanan hastalar çalışma dışı bırakıldı. HbA1c ve 25OH Vitamin-D3 düzeyleri 9 aylık dönemde 3 kez ölçüldü ve ölçümlerin ortalaması kullanıldı. Diyabetik hastalar ve kontrol grubu D vitamini düzeylerine göre; eksiklik 12 ngml, yetersizlik 12-20 ngml ve yeterlilik 20 ngml olmak üzere üç gruba ayrıldı. Bulgular: Diyabetik hastaların serum 25 OH D vitamini düzeyleri sağlıklı bireylerden anlamlı olarak daha düşüktü p0,024. Ancak, diyabetik erişkinler 25OH D vitamini düzeylerine göre 3 gruba ayrıldığında HbA1c düzeyleri açısından anlamlı fark yoktu p0,905. Sonuç: Preklinik veriler, tip 1 diabetes mellitus etiyopatogenezinde düşük serum D vitamini düzeylerinin rolünü desteklese de, düşük serum D vitamini düzeyleri ile tip 1 diyabet prevalansı veya glisemik kontrol arasındaki bağlantıyı inceleyen çalışmalar, bizim çalışmamız da dahil olmak üzere, net bir sonuca ulaşmak için yeterli değildir.

Makale detayları

25-Hydroxyvitamin D Status In Type 1 Diabetic Adults And Its Relationship With Glycemic Control

Yazarlar:

Burak Andaç | Buket Yılmaz Bülbül | Mehmet Oğulcan Tezel | Mine Okur | Serpil Yanık Çolak | Buse Ekici | Mehmet Celik

Yayıncı:

Akdeniz University

Ana Başlıklar:

Klinik Tıp Bilimleri

Dergi:

Akdeniz Tıp Dergisi Vol.10 Issue 2, pp.284-288

Belge Tipi:

Makale

Yayın Tarihi:

1/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001317191

pISSN:

2687-2781

type 1 diabetes mellitus

vitamin D

glycemic controltip 1 diabetes mellitus

D vitamini

glisemik kontrol.

Sayı

Makale detayları

25-Hydroxyvitamin D Status In Type 1 Diabetic Adults And Its Relationship With Glycemic Control

Yazarlar: Burak Andaç | Buket Yılmaz Bülbül | Mehmet Oğulcan Tezel | Mine Okur | Serpil Yanık Çolak | Buse Ekici | Mehmet Celik

Yayıncı: Akdeniz University

Ana Başlıklar: Klinik Tıp Bilimleri

Dergi: Akdeniz Tıp Dergisi Vol.10 Issue 2, pp.284-288

Belge Tipi: Makale

Yayın Tarihi: 1/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001317191

pISSN: 2687-2781

type 1 diabetes mellitus

vitamin D

glycemic controltip 1 diabetes mellitus

D vitamini

glisemik kontrol.

Sayı

Yazarlar:

Burak Andaç | Buket Yılmaz Bülbül | Mehmet Oğulcan Tezel | Mine Okur | Serpil Yanık Çolak | Buse Ekici | Mehmet Celik

Yayıncı:

Akdeniz University

Ana Başlıklar:

Klinik Tıp Bilimleri

Dergi:

Akdeniz Tıp Dergisi Vol.10 Issue 2, pp.284-288

Belge Tipi:

Makale

Yayın Tarihi:

1/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001317191

pISSN:

2687-2781