Relationship between Oxidized Low-Density Lipoprotein Treatment and Hepatocellular Carcinoma Associated Transcript 1 Expression

Burcu Bayyurt

Makale detayları

Relationship between Oxidized Low-Density Lipoprotein Treatment and Hepatocellular Carcinoma Associated Transcript 1 Expression

Yazarlar:

Burcu Bayyurt

Yayıncı:

Karyay Karadeniz Yayımcılık

Ana Başlıklar:

Epidemiyoloji (Diğer)

Dergi:

Black Sea Journal of Health Science Vol.8 Issue 1, pp.17-20

Belge Tipi:

Makale

Yayın Tarihi:

1/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001338666

pISSN:

2619-9041

Anahtar kelimeler:

Özet:

 Long non-coding RNAs lncRNAs have multiple biological functions in the vascular system including in endothelial cells ECs. Hepatocellular carcinoma associated transcript 1 HULC is a lncRNA and highly up-regulated in liver cancer. Oxidized low-density lipoprotein ox-LDL is a remarkable risk factor for various disease. We investigated and compared HULC expression in human umbilical vein endothelial cells HUVECs treated with two different concentration of ox-LDL. We used quantitative polymerase chain reaction qPCR method to detect HULC expression level in HUVECs. HULC expression was found to be statistic significantly up-regulated in HUVECs treated with higher concentration of ox-LDL P0.001. It may be put forward that high concentration of ox-LDL treatment may be inducer of HULC gene expression in variety of diseases including in cancer and cardiovascular diseases CVDs.

 Long non-coding RNAs lncRNAs have multiple biological functions in the vascular system including in endothelial cells ECs. Hepatocellular carcinoma associated transcript 1 HULC is a lncRNA and highly up-regulated in liver cancer. Oxidized low-density lipoprotein ox-LDL is a remarkable risk factor for various disease. We investigated and compared HULC expression in human umbilical vein endothelial cells HUVECs treated with two different concentration of ox-LDL. We used quantitative polymerase chain reaction qPCR method to detect HULC expression level in HUVECs. HULC expression was found to be statistic significantly up-regulated in HUVECs treated with higher concentration of ox-LDL P0.001. It may be put forward that high concentration of ox-LDL treatment may be inducer of HULC gene expression in variety of diseases including in cancer and cardiovascular diseases CVDs.

 Long non-coding RNAs lncRNAs have multiple biological functions in the vascular system including in endothelial cells ECs. Hepatocellular carcinoma associated transcript 1 HULC is a lncRNA and highly up-regulated in liver cancer. Oxidized low-density lipoprotein ox-LDL is a remarkable risk factor for various disease. We investigated and compared HULC expression in human umbilical vein endothelial cells HUVECs treated with two different concentration of ox-LDL. We used quantitative polymerase chain reaction qPCR method to detect HULC expression level in HUVECs. HULC expression was found to be statistic significantly up-regulated in HUVECs treated with higher concentration of ox-LDL P0.001. It may be put forward that high concentration of ox-LDL treatment may be inducer of HULC gene expression in variety of diseases including in cancer and cardiovascular diseases CVDs.

 Long non-coding RNAs lncRNAs have multiple biological functions in the vascular system including in endothelial cells ECs. Hepatocellular carcinoma associated transcript 1 HULC is a lncRNA and highly up-regulated in liver cancer. Oxidized low-density lipoprotein ox-LDL is a remarkable risk factor for various disease. We investigated and compared HULC expression in human umbilical vein endothelial cells HUVECs treated with two different concentration of ox-LDL. We used quantitative polymerase chain reaction qPCR method to detect HULC expression level in HUVECs. HULC expression was found to be statistic significantly up-regulated in HUVECs treated with higher concentration of ox-LDL P0.001. It may be put forward that high concentration of ox-LDL treatment may be inducer of HULC gene expression in variety of diseases including in cancer and cardiovascular diseases CVDs.

Makale detayları

Relationship between Oxidized Low-Density Lipoprotein Treatment and Hepatocellular Carcinoma Associated Transcript 1 Expression

Yazarlar:

Burcu Bayyurt

Yayıncı:

Karyay Karadeniz Yayımcılık

Ana Başlıklar:

Epidemiyoloji (Diğer)

Dergi:

Black Sea Journal of Health Science Vol.8 Issue 1, pp.17-20

Belge Tipi:

Makale

Yayın Tarihi:

1/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001338666

pISSN:

2619-9041

Hepatocellular carcinoma associated transcript 1

Oxidized low-density lipoprotein

Gene expression

Quantitative polymerase chain reactionHepatocellular carcinoma associated transcript 1

Oxidized low-density lipoprotein

Gene expression

Quantitative polymerase chain reaction

Sayı

Makale detayları

Yazarlar: Burcu Bayyurt

Yayıncı: Karyay Karadeniz Yayımcılık

Ana Başlıklar: Epidemiyoloji (Diğer)

Dergi: Black Sea Journal of Health Science Vol.8 Issue 1, pp.17-20

Belge Tipi: Makale

Yayın Tarihi: 1/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001338666

pISSN: 2619-9041

Sayı

Yazarlar:

Burcu Bayyurt

Yayıncı:

Karyay Karadeniz Yayımcılık

Ana Başlıklar:

Epidemiyoloji (Diğer)

Dergi:

Black Sea Journal of Health Science Vol.8 Issue 1, pp.17-20

Belge Tipi:

Makale

Yayın Tarihi:

1/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001338666

pISSN:

2619-9041