Thermosensitive in situ gel formulation and characterization studies of Sambucus ebulus L. extract

Umay Merve Güven; Yusuf Yakut; Nurdan Çakır; Serpil Demirci Kayıran

Makale detayları

Thermosensitive in situ gel formulation and characterization studies of Sambucus ebulus L. extract

Yazarlar:

Umay Merve Güven | Yusuf Yakut | Nurdan Çakır | Serpil Demirci Kayıran

Yayıncı:

Istanbul University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences

Dergi:

İstanbul Journal of Pharmacy Vol.53 Issue 1, pp.30-38

Belge Tipi:

Makale

Yayın Tarihi:

4/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001289621

pISSN:

2587-2087

Anahtar kelimeler:

Özet:

 Background and Aims: Sambucus ebulus L. has been used to treat inflammation-related gastrointestinal disorders, influen- za, kidney ailments, lung diseases, rheumatoid arthritis, and snake and insect bites. Our study provides important ethnobo- tanical information about S. ebulus with the aim of developing a formulation with increased extract bioavailability, diminished side effects, and easy drug loading and dose adjustment as an effective local therapy for dermatologic diseases. Methods: Twelve in-situ gels with S. ebulus were prepared as antifungal treatments in accordance with the cold method and formulated using poloxamer and hydroxypropyl methylcellulose HPMC. The formulations were characterized in terms of pH, gelling capacity, swelling degree, spreadability, and rheological properties. Results: Among the prepared in situ gel formulations, the Poloxamer 407 and 407-HPMC mixtures of P14H1 and P15 demon- strated acceptable gelation temperatures for dermal use. Conclusion: Thermosensitive in-situ gels containing S. ebulus may be a viable alternative for treating fungal diseases.

 Background and Aims: Sambucus ebulus L. has been used to treat inflammation-related gastrointestinal disorders, influen- za, kidney ailments, lung diseases, rheumatoid arthritis, and snake and insect bites. Our study provides important ethnobo- tanical information about S. ebulus with the aim of developing a formulation with increased extract bioavailability, diminished side effects, and easy drug loading and dose adjustment as an effective local therapy for dermatologic diseases. Methods: Twelve in-situ gels with S. ebulus were prepared as antifungal treatments in accordance with the cold method and formulated using poloxamer and hydroxypropyl methylcellulose HPMC. The formulations were characterized in terms of pH, gelling capacity, swelling degree, spreadability, and rheological properties. Results: Among the prepared in situ gel formulations, the Poloxamer 407 and 407-HPMC mixtures of P14H1 and P15 demon- strated acceptable gelation temperatures for dermal use. Conclusion: Thermosensitive in-situ gels containing S. ebulus may be a viable alternative for treating fungal diseases.

 Background and Aims: Sambucus ebulus L. has been used to treat inflammation-related gastrointestinal disorders, influen- za, kidney ailments, lung diseases, rheumatoid arthritis, and snake and insect bites. Our study provides important ethnobo- tanical information about S. ebulus with the aim of developing a formulation with increased extract bioavailability, diminished side effects, and easy drug loading and dose adjustment as an effective local therapy for dermatologic diseases. Methods: Twelve in-situ gels with S. ebulus were prepared as antifungal treatments in accordance with the cold method and formulated using poloxamer and hydroxypropyl methylcellulose HPMC. The formulations were characterized in terms of pH, gelling capacity, swelling degree, spreadability, and rheological properties. Results: Among the prepared in situ gel formulations, the Poloxamer 407 and 407-HPMC mixtures of P14H1 and P15 demon- strated acceptable gelation temperatures for dermal use. Conclusion: Thermosensitive in-situ gels containing S. ebulus may be a viable alternative for treating fungal diseases.

 Background and Aims: Sambucus ebulus L. has been used to treat inflammation-related gastrointestinal disorders, influen- za, kidney ailments, lung diseases, rheumatoid arthritis, and snake and insect bites. Our study provides important ethnobo- tanical information about S. ebulus with the aim of developing a formulation with increased extract bioavailability, diminished side effects, and easy drug loading and dose adjustment as an effective local therapy for dermatologic diseases. Methods: Twelve in-situ gels with S. ebulus were prepared as antifungal treatments in accordance with the cold method and formulated using poloxamer and hydroxypropyl methylcellulose HPMC. The formulations were characterized in terms of pH, gelling capacity, swelling degree, spreadability, and rheological properties. Results: Among the prepared in situ gel formulations, the Poloxamer 407 and 407-HPMC mixtures of P14H1 and P15 demon- strated acceptable gelation temperatures for dermal use. Conclusion: Thermosensitive in-situ gels containing S. ebulus may be a viable alternative for treating fungal diseases.

Makale detayları

Thermosensitive in situ gel formulation and characterization studies of Sambucus ebulus L. extract

Yazarlar:

Umay Merve Güven | Yusuf Yakut | Nurdan Çakır | Serpil Demirci Kayıran

Yayıncı:

Istanbul University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences

Dergi:

İstanbul Journal of Pharmacy Vol.53 Issue 1, pp.30-38

Belge Tipi:

Makale

Yayın Tarihi:

4/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001289621

pISSN:

2587-2087

Sambucus ebulus L.

in-situ gel

gelling system

topical antifungal

Sayı

Makale detayları

Thermosensitive in situ gel formulation and characterization studies of Sambucus ebulus L. extract

Yazarlar: Umay Merve Güven | Yusuf Yakut | Nurdan Çakır | Serpil Demirci Kayıran

Yayıncı: Istanbul University

Ana Başlıklar: Pharmacology and Pharmaceutical Sciences

Dergi: İstanbul Journal of Pharmacy Vol.53 Issue 1, pp.30-38

Belge Tipi: Makale

Yayın Tarihi: 4/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001289621

pISSN: 2587-2087

Sambucus ebulus L.

in-situ gel

gelling system

topical antifungal

Sayı

Yazarlar:

Umay Merve Güven | Yusuf Yakut | Nurdan Çakır | Serpil Demirci Kayıran

Yayıncı:

Istanbul University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences

Dergi:

İstanbul Journal of Pharmacy Vol.53 Issue 1, pp.30-38

Belge Tipi:

Makale

Yayın Tarihi:

4/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001289621

pISSN:

2587-2087