Analyses of C-Reactive Protein, Endothelial Nitric Oxide Synthase and Interleukin-6 Gene Polymorphisms in Adolescents with a Family History of Premature Coronary Artery Disease: A Pilot Study

Ataç ÇELİK; Fatih ALTUNKAŞ; Kayıhan KARAMAN; Metin KARAYAKALI; Köksal CEYHAN; Mustafa ÖZÇETİN; Ömer ATEŞ; İlker AKAR; İlker İNCE; Murat YALÇIN; Fatih KOÇ

Makale detayları

Analyses of C-Reactive Protein, Endothelial Nitric Oxide Synthase and Interleukin-6 Gene Polymorphisms in Adolescents with a Family History of Premature Coronary Artery Disease: A Pilot Study

Yazarlar:

Ataç ÇELİK | Fatih ALTUNKAŞ | Kayıhan KARAMAN | Metin KARAYAKALI | Köksal CEYHAN | Mustafa ÖZÇETİN | Ömer ATEŞ | İlker AKAR | İlker İNCE | Murat YALÇIN | Fatih KOÇ

Yayıncı:

Trakya University

Dergi:

Balkan Medical Journal 2015 Vol.32 Issue 4, pp.397-402

Belge Tipi:

Makale

Yayın Tarihi:

9/2015

Belge Dili:

Türkçe

Document ID (Org No.):

2000759787

Sıklık:

İki Aylık

pISSN:

2146-3123

Özet:

 

Background: Family history of premature atherosclerosis imposes a high risk to people. The relationship between atherosclerosis and gene polymorphisms of various biomarkers such as Endothelial Nitric Oxide Synthase (eNOS), C-Reactive Protein (CRP), and Interleukin-6 (IL-6) has shown in previous studies.     Aims: The major aim of the study was to evaluate the CRP, eNOS, and IL-6 gene polymorphisms in a group of adolescents who have a parental history of early coronary artery disease (CAD).     Study Design: Case-control study.     Methods: Thirty-six volunteers with a father with obstructive CAD during the first four decades and 46 subjects with a father with normal coronary arteries documented with coronary angiography were included in the study. Polymerase chain reaction-restriction fragment length polymorphism techniques were used to analyze CRP, eNOS, and IL-6 polymorphisms.     Results: We did not find any differences between the two groups with regard to age, sex, body mass index, renal functions, systolic and diastolic blood pressures, lipid profile, and fasting glucose, hemoglobin, and high sensitivity CRP. A significant difference was only observed in IL-6-572 G/C genotype distribution and allele frequency between two groups (Pc=0.036 OR=3.48 CI (95%) 1.17-10.32).     Conclusion: The present study showed a significant association between the IL-6-572 G/C gene polymorphism (presence of C allele) and adolescents with a parental history of premature CAD.

Makale detayları

Analyses of C-Reactive Protein, Endothelial Nitric Oxide Synthase and Interleukin-6 Gene Polymorphisms in Adolescents with a Family History of Premature Coronary Artery Disease: A Pilot Study

Yazarlar: Ataç ÇELİK | Fatih ALTUNKAŞ | Kayıhan KARAMAN | Metin KARAYAKALI | Köksal CEYHAN | Mustafa ÖZÇETİN | Ömer ATEŞ | İlker AKAR | İlker İNCE | Murat YALÇIN | Fatih KOÇ

Yayıncı: Trakya University

Dergi: Balkan Medical Journal 2015 Vol.32 Issue 4, pp.397-402

Belge Tipi: Makale

Yayın Tarihi: 9/2015

Belge Dili: Türkçe

Document ID (Org No.): 2000759787

Sıklık: İki Aylık

pISSN: 2146-3123

Sayı

Yazarlar:

Ataç ÇELİK | Fatih ALTUNKAŞ | Kayıhan KARAMAN | Metin KARAYAKALI | Köksal CEYHAN | Mustafa ÖZÇETİN | Ömer ATEŞ | İlker AKAR | İlker İNCE | Murat YALÇIN | Fatih KOÇ

Yayıncı:

Trakya University

Dergi:

Balkan Medical Journal 2015 Vol.32 Issue 4, pp.397-402

Belge Tipi:

Makale

Yayın Tarihi:

9/2015

Belge Dili:

Türkçe

Document ID (Org No.):

2000759787

Sıklık:

İki Aylık

pISSN:

2146-3123