Thermodynamic protonation constant values of meclizine and buclizine in acetonitrile-water binary mixtures

Ebru Çubuk Demiralay

Makale detayları

Thermodynamic protonation constant values of meclizine and buclizine in acetonitrile-water binary mixtures

Yazarlar:

Ebru Çubuk Demiralay

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Analytical Chemistry

Dergi:

Journal of Research in Pharmacy Vol.25 Issue 1, pp.42-51

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346152

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 In the study, the retention times tR values for meclizine MCZ and buclizine BCZ structurally related benzhydrylpiperazine were determined to modeling the dependence of retention on the acetonitrile concentration in the mobile phase. Reversed-phase liquid chromatography RPLC analysis of the MCZ and BCZ was realized with polar embedded amide 15x0.46 cm I.D, 5μm column. The mobile phase pH range is selected from 5.0-9.0 to determine the structural changes due to protonation that result from a change in pH. The different retention time were attributed to their different hydrophobicities and ionization degree. The thermodynamic protonation constant     value for investigated compounds was calculated using the tR relationship to pH of the mobile phase and  effect of the activity coefficients. Linear correlation between  values and macroscopic parameters XACN, 1ε was   also determined.

 In the study, the retention times tR values for meclizine MCZ and buclizine BCZ structurally related benzhydrylpiperazine were determined to modeling the dependence of retention on the acetonitrile concentration in the mobile phase. Reversed-phase liquid chromatography RPLC analysis of the MCZ and BCZ was realized with polar embedded amide 15x0.46 cm I.D, 5μm column. The mobile phase pH range is selected from 5.0-9.0 to determine the structural changes due to protonation that result from a change in pH. The different retention time were attributed to their different hydrophobicities and ionization degree. The thermodynamic protonation constant     value for investigated compounds was calculated using the tR relationship to pH of the mobile phase and  effect of the activity coefficients. Linear correlation between  values and macroscopic parameters XACN, 1ε was   also determined.

 In the study, the retention times tR values for meclizine MCZ and buclizine BCZ structurally related benzhydrylpiperazine were determined to modeling the dependence of retention on the acetonitrile concentration in the mobile phase. Reversed-phase liquid chromatography RPLC analysis of the MCZ and BCZ was realized with polar embedded amide 15x0.46 cm I.D, 5μm column. The mobile phase pH range is selected from 5.0-9.0 to determine the structural changes due to protonation that result from a change in pH. The different retention time were attributed to their different hydrophobicities and ionization degree. The thermodynamic protonation constant     value for investigated compounds was calculated using the tR relationship to pH of the mobile phase and  effect of the activity coefficients. Linear correlation between  values and macroscopic parameters XACN, 1ε was   also determined.

 In the study, the retention times tR values for meclizine MCZ and buclizine BCZ structurally related benzhydrylpiperazine were determined to modeling the dependence of retention on the acetonitrile concentration in the mobile phase. Reversed-phase liquid chromatography RPLC analysis of the MCZ and BCZ was realized with polar embedded amide 15x0.46 cm I.D, 5μm column. The mobile phase pH range is selected from 5.0-9.0 to determine the structural changes due to protonation that result from a change in pH. The different retention time were attributed to their different hydrophobicities and ionization degree. The thermodynamic protonation constant     value for investigated compounds was calculated using the tR relationship to pH of the mobile phase and  effect of the activity coefficients. Linear correlation between  values and macroscopic parameters XACN, 1ε was   also determined.

Makale detayları

Thermodynamic protonation constant values of meclizine and buclizine in acetonitrile-water binary mixtures

Yazarlar:

Ebru Çubuk Demiralay

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Analytical Chemistry

Dergi:

Journal of Research in Pharmacy Vol.25 Issue 1, pp.42-51

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346152

pISSN:

2630-6344

Benzhydrylpiperazine compounds

thermodynamic value

extrapolation methods

reversed-phaseliquid chromatography

Sayı

Makale detayları

Thermodynamic protonation constant values of meclizine and buclizine in acetonitrile-water binary mixtures

Yazarlar: Ebru Çubuk Demiralay

Yayıncı: Marmara University

Ana Başlıklar: Pharmaceutical Analytical Chemistry

Dergi: Journal of Research in Pharmacy Vol.25 Issue 1, pp.42-51

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001346152

pISSN: 2630-6344

Benzhydrylpiperazine compounds

thermodynamic value

extrapolation methods

reversed-phaseliquid chromatography

Sayı

Yazarlar:

Ebru Çubuk Demiralay

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Analytical Chemistry

Dergi:

Journal of Research in Pharmacy Vol.25 Issue 1, pp.42-51

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346152

pISSN:

2630-6344