The influence of anesthesia type on recurrence of the non-muscle invasive bladder tumor according to risk groups: 3 year follow up

Sinan Çelen; Aslı Mete; Yusuf Özlülerden; Mesut Berkan Duran; Kürşat Küçüker; Alper Şimşek; Aykut Başer; Yunus Yaz; Kadir Ömür Günseven

Makale detayları

The influence of anesthesia type on recurrence of the non-muscle invasive bladder tumor according to risk groups: 3 year follow up

Yazarlar:

Sinan Çelen | Aslı Mete | Yusuf Özlülerden | Mesut Berkan Duran | Kürşat Küçüker | Alper Şimşek | Aykut Başer | Yunus Yaz | Kadir Ömür Günseven

Yayıncı:

Pamukkale University

Ana Başlıklar:

Üroloji

Dergi:

Pamukkale Tıp Dergisi Vol.18 Issue 1, pp.53-60

Belge Tipi:

Makale

Yayın Tarihi:

1/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001318836

pISSN:

1308-0865

Anahtar kelimeler:

Özet:

 Purpose: Many risk factors affecting bladder cancer recurrence, such as genetic and environmental factors, have been previously identified. It has been stated that risk factors that cause immunosuppression play a role in the spread of cancer cells. Anesthetic agent, which is a perioperative factor, may affect the risk of cancer recurrence by disrupting the immune system. The aim of this study was to compare the effect of regional anesthesia RA and general anesthesia GA on non-muscle invasive bladder cancers NMIBC recurrence. Materials and methods: A total of one hundred seventy-eight patients who underwent transurethral bladder tumor resection TURBT for NMIBC and underwent surgery under GA or RA between 2011 and 2016 in the urology departments of Pamukkale University and Uludağ University were included in the study. In the first group, 80 patients had RA. In the second group, 98 patients underwent GA during TURBT for NMIBC. Results: The recurrence time was shorter in the GA group 5.5 months than in the RA group 11 months p0.015. First-year relapse was higher in the GA group than in the RA group p0.048, but there was no difference in third-year relapse between groups p0.810. The mean recurrence time was 11 months 95 CI; 9.058 - 12.942 in the RA group and 5 months 95 CI; 2.090 - 7.910 in the GA group p0.031. Conclusion: During transurethral resection of the bladder tumor, an increase in the recurrence time was observed in patients with intermediate-risk NMIBC who received RA compared to patients who received GA. RA provided a 7-month benefit in relapse delay.

 Purpose: Many risk factors affecting bladder cancer recurrence, such as genetic and environmental factors, have been previously identified. It has been stated that risk factors that cause immunosuppression play a role in the spread of cancer cells. Anesthetic agent, which is a perioperative factor, may affect the risk of cancer recurrence by disrupting the immune system. The aim of this study was to compare the effect of regional anesthesia RA and general anesthesia GA on non-muscle invasive bladder cancers NMIBC recurrence. Materials and methods: A total of one hundred seventy-eight patients who underwent transurethral bladder tumor resection TURBT for NMIBC and underwent surgery under GA or RA between 2011 and 2016 in the urology departments of Pamukkale University and Uludağ University were included in the study. In the first group, 80 patients had RA. In the second group, 98 patients underwent GA during TURBT for NMIBC. Results: The recurrence time was shorter in the GA group 5.5 months than in the RA group 11 months p0.015. First-year relapse was higher in the GA group than in the RA group p0.048, but there was no difference in third-year relapse between groups p0.810. The mean recurrence time was 11 months 95 CI; 9.058 - 12.942 in the RA group and 5 months 95 CI; 2.090 - 7.910 in the GA group p0.031. Conclusion: During transurethral resection of the bladder tumor, an increase in the recurrence time was observed in patients with intermediate-risk NMIBC who received RA compared to patients who received GA. RA provided a 7-month benefit in relapse delay.

 Purpose: Many risk factors affecting bladder cancer recurrence, such as genetic and environmental factors, have been previously identified. It has been stated that risk factors that cause immunosuppression play a role in the spread of cancer cells. Anesthetic agent, which is a perioperative factor, may affect the risk of cancer recurrence by disrupting the immune system. The aim of this study was to compare the effect of regional anesthesia RA and general anesthesia GA on non-muscle invasive bladder cancers NMIBC recurrence. Materials and methods: A total of one hundred seventy-eight patients who underwent transurethral bladder tumor resection TURBT for NMIBC and underwent surgery under GA or RA between 2011 and 2016 in the urology departments of Pamukkale University and Uludağ University were included in the study. In the first group, 80 patients had RA. In the second group, 98 patients underwent GA during TURBT for NMIBC. Results: The recurrence time was shorter in the GA group 5.5 months than in the RA group 11 months p0.015. First-year relapse was higher in the GA group than in the RA group p0.048, but there was no difference in third-year relapse between groups p0.810. The mean recurrence time was 11 months 95 CI; 9.058 - 12.942 in the RA group and 5 months 95 CI; 2.090 - 7.910 in the GA group p0.031. Conclusion: During transurethral resection of the bladder tumor, an increase in the recurrence time was observed in patients with intermediate-risk NMIBC who received RA compared to patients who received GA. RA provided a 7-month benefit in relapse delay.

 Amaç: Mesane kanseri nüksünü etkileyen genetik ve çevresel faktörler gibi birçok risk faktörü önceden belirlenmiştir. İmmünsüpresyon yaratan risk faktörlerinin, kanser hücrelerinin yayılmasında rol oynadığı belirtilmiştir. Perioperatif bir faktör olan anestezik ajan, bağışıklık sistemini bozarak kanser nüksü riskini etkileyebilir. Bu çalışmanın amacı, bölgesel anestezi BA ve genel anestezi GA etkilerini özellikle kas invaziv olmayan mesane kanseri KİOMK nüksü üzerinde karşılaştırmaktır. Materyal ve Metod: Pamukkale Üniversitesi ve Uludağ Üniversitesi üroloji bölümlerinde 2011-2016 yılları arasında KİOMK için transüretral mesane tümör rezeksiyonu TURM geçiren toplamda 178 hasta çalışmaya dahil edildi. Birinci grupta 80 hasta BA aldı. İkinci grupta ise 98 hasta KİOMK için TURM sırasında GA aldı. Bulgular: Nüks süresi GA grubunda 5.5 ay BA grubundan 11 ay daha kısa idi p0.015. İlk yıl nüks, GA grubunda BA grubuna göre daha yüksekti p0.048, ancak gruplar arasında üçüncü yıl nüksünde farklılık yoktu p0.810. Ortalama nüks süresi BA grubunda 11 ay 95 CI; 9.058-12.942 ve GA grubunda 5 ay 95 CI; 2.090-7.910 idi p0.031. Sonuç: Mesane tümörünün transüretral rezeksiyonu sırasında BA alan orta riskli KİOMK hastalarında GA alan hastalara göre nüks süresinde artış gözlendi. BA, nüks gecikmesinde 7 aylık bir fayda sağladı.

Makale detayları

The influence of anesthesia type on recurrence of the non-muscle invasive bladder tumor according to risk groups: 3 year follow up

Yazarlar:

Sinan Çelen | Aslı Mete | Yusuf Özlülerden | Mesut Berkan Duran | Kürşat Küçüker | Alper Şimşek | Aykut Başer | Yunus Yaz | Kadir Ömür Günseven

Yayıncı:

Pamukkale University

Ana Başlıklar:

Üroloji

Dergi:

Pamukkale Tıp Dergisi Vol.18 Issue 1, pp.53-60

Belge Tipi:

Makale

Yayın Tarihi:

1/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001318836

pISSN:

1308-0865

Bladder cancer

bladder tumor

regional anesthesia

general anesthesiaMesane kanseri

mesane tümörü

bölgesel anestezi

genel anestezi.

Sayı

Makale detayları

Yazarlar: Sinan Çelen | Aslı Mete | Yusuf Özlülerden | Mesut Berkan Duran | Kürşat Küçüker | Alper Şimşek | Aykut Başer | Yunus Yaz | Kadir Ömür Günseven

Yayıncı: Pamukkale University

Ana Başlıklar: Üroloji

Dergi: Pamukkale Tıp Dergisi Vol.18 Issue 1, pp.53-60

Belge Tipi: Makale

Yayın Tarihi: 1/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001318836

pISSN: 1308-0865

Sayı

Yazarlar:

Sinan Çelen | Aslı Mete | Yusuf Özlülerden | Mesut Berkan Duran | Kürşat Küçüker | Alper Şimşek | Aykut Başer | Yunus Yaz | Kadir Ömür Günseven

Yayıncı:

Pamukkale University

Ana Başlıklar:

Üroloji

Dergi:

Pamukkale Tıp Dergisi Vol.18 Issue 1, pp.53-60

Belge Tipi:

Makale

Yayın Tarihi:

1/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001318836

pISSN:

1308-0865