Risk factors for lymph node involvement in early stage cervical cancer A retrospective cohort study

Vakkas Korkmaz; Esra Keles; Koray Aslan; Bülent Özdal

Makale detayları

Risk factors for lymph node involvement in early stage cervical cancer A retrospective cohort study

Yazarlar:

Vakkas Korkmaz | Esra Keles | Koray Aslan | Bülent Özdal

Yayıncı:

Ondokuz Mayıs University

Ana Başlıklar:

Gynecologic Oncology Surgery

Dergi:

Deneysel ve Klinik Tıp Dergisi Vol.42 Issue 1, pp.1-4

Belge Tipi:

Makale

Yayın Tarihi:

3/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001344470

pISSN:

1309-4483

Anahtar kelimeler:

Özet:

 One of the most important prognostic factors in cervical cancer is lymph node involvement that affects disease-free survival and plays an important role in the treatment. This study aimed to determine the factors affecting lymph node involvement in early stage cervical cancer. A total of 169 cervical cancer patients with stage IA2-IIA2 were enrolled. Age, histologic subtype, deep stromal invasion DSI, largest tumor diameter LTD, lymphovascular space invasion LVSI, vaginal surgical margin, ovarian metastasis status, parametrial involvement, lymph node count and presence of metastasis were retrospectively reviewed. All of these parameters are divided into two groups: LNM positive group 1 and negative group 2. The median age of the patients was 52 26-77 years. In the univariate regression analysis; LVSI p 0.001, DSI p0.018, parametrial involvement p  0.001, and vaginal surgical margin positivity p  0.020 were in statistically significant correlations with lymph node involvement. In multivariate regression analysis, LVSI 51118 43.2 vs 751 13.7, OR  3.9, p  0.003 and parametrial involvement 1624 66.6 vs 42145 28.9, OR  3.9, p  0.009 were the independent risk factors for lymph node metastasis. LVSI and parametrial involvement are two crucial risk factors for lymph node metastasis in patients diagnosed with early-stage cervical cancer.

 One of the most important prognostic factors in cervical cancer is lymph node involvement that affects disease-free survival and plays an important role in the treatment. This study aimed to determine the factors affecting lymph node involvement in early stage cervical cancer. A total of 169 cervical cancer patients with stage IA2-IIA2 were enrolled. Age, histologic subtype, deep stromal invasion DSI, largest tumor diameter LTD, lymphovascular space invasion LVSI, vaginal surgical margin, ovarian metastasis status, parametrial involvement, lymph node count and presence of metastasis were retrospectively reviewed. All of these parameters are divided into two groups: LNM positive group 1 and negative group 2. The median age of the patients was 52 26-77 years. In the univariate regression analysis; LVSI p 0.001, DSI p0.018, parametrial involvement p  0.001, and vaginal surgical margin positivity p  0.020 were in statistically significant correlations with lymph node involvement. In multivariate regression analysis, LVSI 51118 43.2 vs 751 13.7, OR  3.9, p  0.003 and parametrial involvement 1624 66.6 vs 42145 28.9, OR  3.9, p  0.009 were the independent risk factors for lymph node metastasis. LVSI and parametrial involvement are two crucial risk factors for lymph node metastasis in patients diagnosed with early-stage cervical cancer.

 One of the most important prognostic factors in cervical cancer is lymph node involvement that affects disease-free survival and plays an important role in the treatment. This study aimed to determine the factors affecting lymph node involvement in early stage cervical cancer. A total of 169 cervical cancer patients with stage IA2-IIA2 were enrolled. Age, histologic subtype, deep stromal invasion DSI, largest tumor diameter LTD, lymphovascular space invasion LVSI, vaginal surgical margin, ovarian metastasis status, parametrial involvement, lymph node count and presence of metastasis were retrospectively reviewed. All of these parameters are divided into two groups: LNM positive group 1 and negative group 2. The median age of the patients was 52 26-77 years. In the univariate regression analysis; LVSI p 0.001, DSI p0.018, parametrial involvement p  0.001, and vaginal surgical margin positivity p  0.020 were in statistically significant correlations with lymph node involvement. In multivariate regression analysis, LVSI 51118 43.2 vs 751 13.7, OR  3.9, p  0.003 and parametrial involvement 1624 66.6 vs 42145 28.9, OR  3.9, p  0.009 were the independent risk factors for lymph node metastasis. LVSI and parametrial involvement are two crucial risk factors for lymph node metastasis in patients diagnosed with early-stage cervical cancer.

 One of the most important prognostic factors in cervical cancer is lymph node involvement that affects disease-free survival and plays an important role in the treatment. This study aimed to determine the factors affecting lymph node involvement in early stage cervical cancer. A total of 169 cervical cancer patients with stage IA2-IIA2 were enrolled. Age, histologic subtype, deep stromal invasion DSI, largest tumor diameter LTD, lymphovascular space invasion LVSI, vaginal surgical margin, ovarian metastasis status, parametrial involvement, lymph node count and presence of metastasis were retrospectively reviewed. All of these parameters are divided into two groups: LNM positive group 1 and negative group 2. The median age of the patients was 52 26-77 years. In the univariate regression analysis; LVSI p 0.001, DSI p0.018, parametrial involvement p  0.001, and vaginal surgical margin positivity p  0.020 were in statistically significant correlations with lymph node involvement. In multivariate regression analysis, LVSI 51118 43.2 vs 751 13.7, OR  3.9, p  0.003 and parametrial involvement 1624 66.6 vs 42145 28.9, OR  3.9, p  0.009 were the independent risk factors for lymph node metastasis. LVSI and parametrial involvement are two crucial risk factors for lymph node metastasis in patients diagnosed with early-stage cervical cancer.

Makale detayları

Risk factors for lymph node involvement in early stage cervical cancer A retrospective cohort study

Yazarlar:

Vakkas Korkmaz | Esra Keles | Koray Aslan | Bülent Özdal

Yayıncı:

Ondokuz Mayıs University

Ana Başlıklar:

Gynecologic Oncology Surgery

Dergi:

Deneysel ve Klinik Tıp Dergisi Vol.42 Issue 1, pp.1-4

Belge Tipi:

Makale

Yayın Tarihi:

3/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001344470

pISSN:

1309-4483

cervical cancer

; lymph-vascular space invasion

lymph node metastasis

Sayı

Makale detayları

Risk factors for lymph node involvement in early stage cervical cancer A retrospective cohort study

Yazarlar: Vakkas Korkmaz | Esra Keles | Koray Aslan | Bülent Özdal

Yayıncı: Ondokuz Mayıs University

Ana Başlıklar: Gynecologic Oncology Surgery

Dergi: Deneysel ve Klinik Tıp Dergisi Vol.42 Issue 1, pp.1-4

Belge Tipi: Makale

Yayın Tarihi: 3/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001344470

pISSN: 1309-4483

cervical cancer

; lymph-vascular space invasion

lymph node metastasis

Sayı

Yazarlar:

Vakkas Korkmaz | Esra Keles | Koray Aslan | Bülent Özdal

Yayıncı:

Ondokuz Mayıs University

Ana Başlıklar:

Gynecologic Oncology Surgery

Dergi:

Deneysel ve Klinik Tıp Dergisi Vol.42 Issue 1, pp.1-4

Belge Tipi:

Makale

Yayın Tarihi:

3/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001344470

pISSN:

1309-4483