Distribution of Alpha-Actinin-3 (ACTN3) rs1815739 Polymorphism in HADO Athletes

Beste Tacal Aslan; Dudu Banu Yozgatlı; Özlem Özge Yılmaz; Tolga Polat; Rıdvan Ekmekçi; Korkut Ulucan

Makale detayları

Distribution of Alpha-Actinin-3 (ACTN3) rs1815739 Polymorphism in HADO Athletes

Yazarlar:

Beste Tacal Aslan | Dudu Banu Yozgatlı | Özlem Özge Yılmaz | Tolga Polat | Rıdvan Ekmekçi | Korkut Ulucan

Yayıncı:

Marmara University

Ana Başlıklar:

Egzersiz ve Spor Bilimleri (Diğer)

Dergi:

Eurasian Research in Sport Science Vol.9 Issue 2, pp.64-71

Belge Tipi:

Makale

Yayın Tarihi:

12/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001335291

pISSN:

2636-8269

Anahtar kelimeler:

Özet:

 There is growing interest in studying the genetic profile of high-performing athletes and how these genetic factors impact their athletic abilities. ACTN3 is a highly influential gene in determining athletic capabilities. The ACTN3 rs1815739 variant is found on chromosome 11 11q13.1 and is caused by a switch from cytosine to thymine in exon 16. This study aims to examine the ACTN3 rs1815739 genetic variant in HADO athletes. Eight HADO athletes participated in this study. After isolating DNA from buccal epithelial cells, genotyping was performed using Real-Time PCR PCR. Genotype distribution among athletes was 4 50 CC, 2 25 CT, and 2 25 TT. In the control group, genotypes were 15 50 CC, 8 26.7 CT, and 7 23.3 TT. There was no significant difference between groups p1.000. Allele distribution in athletes was 10 62.5 C and 6 37.5 T, while the control group had 38 63.3 C and 22 36.7 T alleles. The statistical comparison showed no significant difference p0.951. The results showed that the CC genotype was higher compared to the CT and TT genotypes. At the same time, the C allele was also found. percent higher than the T allele. Research has shown that the C allele is associated with sprintingstrength sports. This is the first study of athletic performance in HADO athletes.

 There is growing interest in studying the genetic profile of high-performing athletes and how these genetic factors impact their athletic abilities. ACTN3 is a highly influential gene in determining athletic capabilities. The ACTN3 rs1815739 variant is found on chromosome 11 11q13.1 and is caused by a switch from cytosine to thymine in exon 16. This study aims to examine the ACTN3 rs1815739 genetic variant in HADO athletes. Eight HADO athletes participated in this study. After isolating DNA from buccal epithelial cells, genotyping was performed using Real-Time PCR PCR. Genotype distribution among athletes was 4 50 CC, 2 25 CT, and 2 25 TT. In the control group, genotypes were 15 50 CC, 8 26.7 CT, and 7 23.3 TT. There was no significant difference between groups p1.000. Allele distribution in athletes was 10 62.5 C and 6 37.5 T, while the control group had 38 63.3 C and 22 36.7 T alleles. The statistical comparison showed no significant difference p0.951. The results showed that the CC genotype was higher compared to the CT and TT genotypes. At the same time, the C allele was also found. percent higher than the T allele. Research has shown that the C allele is associated with sprintingstrength sports. This is the first study of athletic performance in HADO athletes.

 There is growing interest in studying the genetic profile of high-performing athletes and how these genetic factors impact their athletic abilities. ACTN3 is a highly influential gene in determining athletic capabilities. The ACTN3 rs1815739 variant is found on chromosome 11 11q13.1 and is caused by a switch from cytosine to thymine in exon 16. This study aims to examine the ACTN3 rs1815739 genetic variant in HADO athletes. Eight HADO athletes participated in this study. After isolating DNA from buccal epithelial cells, genotyping was performed using Real-Time PCR PCR. Genotype distribution among athletes was 4 50 CC, 2 25 CT, and 2 25 TT. In the control group, genotypes were 15 50 CC, 8 26.7 CT, and 7 23.3 TT. There was no significant difference between groups p1.000. Allele distribution in athletes was 10 62.5 C and 6 37.5 T, while the control group had 38 63.3 C and 22 36.7 T alleles. The statistical comparison showed no significant difference p0.951. The results showed that the CC genotype was higher compared to the CT and TT genotypes. At the same time, the C allele was also found. percent higher than the T allele. Research has shown that the C allele is associated with sprintingstrength sports. This is the first study of athletic performance in HADO athletes.

 Yüksek performanslı sporcuların genetik profillerinin incelenmesine ve bu genetik faktörlerin atletik yeteneklerini nasıl etkilediğine yönelik ilgi artmaktadır. ACTN3, atletik yetenekleri belirlemede oldukça etkili bir gendir. ACTN3 rs1815739 varyantı 11. kromozomda 11q13.1 bulunur ve ekson 16da sitozinden timine geçiş nedeniyle oluşur. Bu çalışma, HADO sporcularındaki ACTN3 rs1815739 genetik varyantını incelemeyi amaçlamaktadır. Bu çalışmaya sekiz HADO sporcusu katıldı. Bukkal epitel hücrelerinden DNA izole edildikten sonra, Real-Time PCR PCR kullanılarak genotipleme yapıldı. Sporcular arasındaki genotip dağılımı 4 50 CC, 2 25 CT ve 2 25 TT idi. Kontrol grubunda genotipler 15 50 CC, 8 26,7 CT ve 7 23,3 TT idi. Gruplar arasında anlamlı bir fark yoktu p1,000. Sporculardaki alel dağılımı 10 62,5 C ve 6 37,5 T iken, kontrol grubunda 38 63,3 C ve 22 36,7 T aleli vardı. İstatistiksel karşılaştırma anlamlı bir fark göstermedi p0,951. Sonuçlar CC genotipinin CT ve TT genotiplerine kıyasla daha yüksek olduğunu gösterdi. Aynı zamanda C aleli de T alelinden yüzde daha yüksek bulundu. Araştırmalar C alelinin sprintgüç sporları ile ilişkili olduğunu göstermiştir. Çalışmamız, HADO sporcularında atletik performans üzerine yapılan ilk çalışmadır.

Makale detayları

Distribution of Alpha-Actinin-3 (ACTN3) rs1815739 Polymorphism in HADO Athletes

Yazarlar:

Beste Tacal Aslan | Dudu Banu Yozgatlı | Özlem Özge Yılmaz | Tolga Polat | Rıdvan Ekmekçi | Korkut Ulucan

Yayıncı:

Marmara University

Ana Başlıklar:

Egzersiz ve Spor Bilimleri (Diğer)

Dergi:

Eurasian Research in Sport Science Vol.9 Issue 2, pp.64-71

Belge Tipi:

Makale

Yayın Tarihi:

12/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001335291

pISSN:

2636-8269

ACTN3

HADO

polymorphism

sport geneticsACTN3

HADO

polimorfizm

spor genetiği

Sayı

Makale detayları

Yazarlar: Beste Tacal Aslan | Dudu Banu Yozgatlı | Özlem Özge Yılmaz | Tolga Polat | Rıdvan Ekmekçi | Korkut Ulucan

Yayıncı: Marmara University

Ana Başlıklar: Egzersiz ve Spor Bilimleri (Diğer)

Dergi: Eurasian Research in Sport Science Vol.9 Issue 2, pp.64-71

Belge Tipi: Makale

Yayın Tarihi: 12/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001335291

pISSN: 2636-8269

Sayı

Yazarlar:

Beste Tacal Aslan | Dudu Banu Yozgatlı | Özlem Özge Yılmaz | Tolga Polat | Rıdvan Ekmekçi | Korkut Ulucan

Yayıncı:

Marmara University

Ana Başlıklar:

Egzersiz ve Spor Bilimleri (Diğer)

Dergi:

Eurasian Research in Sport Science Vol.9 Issue 2, pp.64-71

Belge Tipi:

Makale

Yayın Tarihi:

12/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001335291

pISSN:

2636-8269