Effects of Ankaferd Hemostat on red blood cell aggregation: a hemorheological study

Rafiye ÇİFTÇİLER; Salih AKSU; Neslihan Hacer Dikmenoğlu FALKMARKEN; İbrahim Celalettin HAZNEDAROĞLU

Makale detayları

Effects of Ankaferd Hemostat on red blood cell aggregation: a hemorheological study

Yazarlar:

Rafiye ÇİFTÇİLER | Salih AKSU | Neslihan Hacer Dikmenoğlu FALKMARKEN | İbrahim Celalettin HAZNEDAROĞLU

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2019 Vol.49 Issue 1, pp.356-360

Belge Tipi:

Makale

Yayın Tarihi:

1/2019

Belge Dili:

Türkçe

Document ID (Org No.):

2000750385

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Özet:

 

Background/aim:Ankaferd hemostat (ABS; Ankaferd blood stopper, İstanbul, Turkey) is a prohemostatic agent affecting erythrocytes. The hemostatic action of ABS depends upon fibrinogen gamma chain, prothrombin, and red blood cells. The aim of this study was to assess the effects of ABS on erythrocyte aggregation via hemorheological analyses.Materials and methods: To measure erythrocyte aggregation, blood samples were obtained from healthy, nonsmoker volunteers who had not taken any medication in the previous 10 days. One mL of blood was placed into the laser-assisted optical rotational cell analyzer (LORCA), into the chamber formed by the gap between two concentric glass cylinders. The solution prepared with ABS and saline was added to blood in incremental amounts of 10 μL, 20 μL, 30 μL, 40 μL, 50 μL, 60 μL, 70 μL, and 100 μL. Erythrocyte aggregation was determined by laser-assisted optical rotational cell analyzer at 37 °C. Results: AMPwas found to be 17.7 ± 2.1 au in the blood without ABS, whereas it was lower in the blood with ABS. AMP was 16.0 ± 3.3 in the ABS-added blood group. RBC aggregates did not form faster when cells contacted ABS. The t t½ value was 4.6 ± 2.6 in the ABS-added  blood  group  and  1.9  ±  0.20  in  the  control  group.  Aggregation  was  faster  in  the  control  group  (P  =  0.03).  AI,  which  is  a  combination of AMP and t½, was lowered in the ABS group (48.7 ± 12.3) compared to the control group (65.8 ± 1.6) (P = 0.02). It was notable that the γIsc max (sec-1) value of the control was higher (200 ± 106) than the ABS-added blood group (141 ± 51.0). Conclusion: ABS has antierythroid aggregation effect. ABS inhibits pathological aggregation of red blood cells. Antithrombotic clinical effects of ABS may be ascribed to the antierythroid aggregan actions of the drug.

Makale detayları

Effects of Ankaferd Hemostat on red blood cell aggregation: a hemorheological study

Yazarlar: Rafiye ÇİFTÇİLER | Salih AKSU | Neslihan Hacer Dikmenoğlu FALKMARKEN | İbrahim Celalettin HAZNEDAROĞLU

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2019 Vol.49 Issue 1, pp.356-360

Belge Tipi: Makale

Yayın Tarihi: 1/2019

Belge Dili: Türkçe

Document ID (Org No.): 2000750385

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Sayı

Yazarlar:

Rafiye ÇİFTÇİLER | Salih AKSU | Neslihan Hacer Dikmenoğlu FALKMARKEN | İbrahim Celalettin HAZNEDAROĞLU

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2019 Vol.49 Issue 1, pp.356-360

Belge Tipi:

Makale

Yayın Tarihi:

1/2019

Belge Dili:

Türkçe

Document ID (Org No.):

2000750385

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144