The Relation of Cerebrospinal Fluid Nitric Oxide Levels to Prognosis and Differential Diagnosis of Meningitis

Kasım ÇETİN

Makale detayları

The Relation of Cerebrospinal Fluid Nitric Oxide Levels to Prognosis and Differential Diagnosis of Meningitis

Yazarlar:

Kasım ÇETİN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2002 Vol.32 Issue 5, pp.385-390

Belge Tipi:

Makale

Yayın Tarihi:

4/2002

Belge Dili:

Türkçe

Document ID (Org No.):

2000756898

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

This study was designed to investigate the role of nitric oxide (NO) in the differential diagnosis of bacterial, tuberculous and viral meningitis, and the relation between cerebrospinal fluid (CSF) NO levels and meningitis prognosis.  Twenty patients with bacterial meningitis, 9 with tuberculous meningitis, 11 with viral meningitis/meningoencephalitis and 21 control patients were included in the study. CSF NO levels were investigated by measuring the levels of nitrite with a colorimetric test.  Mean CSF nitrite levels were 3.9 ± 2.0 µmol/l in bacterial meningitis, 2.7 ± 1.9 µmol/l in tuberculous meningitis, 1.9 ± 1.7 µmol/l in viral meningitis/meningoencephalitis and 1.4 ± 1.1 µmol/l in control groups. The patients with bacterial and tuberculous meningitis had higher CSF nitrite levels than the control group (p  0.05). However, there was no significant difference between bacterial and tuberculous meningitis or between tuberculous meningitis and viral meningitis/meningoencephalitis groups. Nitrite levels were correlated with white blood cell (WBC) counts (r = 0.567, p = 0.000), protein (r = 0.548, p < 0.001) and glucose levels (r = -0.271, p < 0.05).   In conclusion, although the measurement of CSF nitrite levels is helpful for the differential diagnosis of meningitis, this parameter is not superior to other routine parameters. However, it may have a characteristic effect on prognosis.

 

This study was designed to investigate the role of nitric oxide (NO) in the differential diagnosis of bacterial, tuberculous and viral meningitis, and the relation between cerebrospinal fluid (CSF) NO levels and meningitis prognosis.  Twenty patients with bacterial meningitis, 9 with tuberculous meningitis, 11 with viral meningitis/meningoencephalitis and 21 control patients were included in the study. CSF NO levels were investigated by measuring the levels of nitrite with a colorimetric test.  Mean CSF nitrite levels were 3.9 ± 2.0 µmol/l in bacterial meningitis, 2.7 ± 1.9 µmol/l in tuberculous meningitis, 1.9 ± 1.7 µmol/l in viral meningitis/meningoencephalitis and 1.4 ± 1.1 µmol/l in control groups. The patients with bacterial and tuberculous meningitis had higher CSF nitrite levels than the control group (p  0.05). However, there was no significant difference between bacterial and tuberculous meningitis or between tuberculous meningitis and viral meningitis/meningoencephalitis groups. Nitrite levels were correlated with white blood cell (WBC) counts (r = 0.567, p = 0.000), protein (r = 0.548, p < 0.001) and glucose levels (r = -0.271, p < 0.05).   In conclusion, although the measurement of CSF nitrite levels is helpful for the differential diagnosis of meningitis, this parameter is not superior to other routine parameters. However, it may have a characteristic effect on prognosis.

Makale detayları

The Relation of Cerebrospinal Fluid Nitric Oxide Levels to Prognosis and Differential Diagnosis of Meningitis

Yazarlar:

Kasım ÇETİN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2002 Vol.32 Issue 5, pp.385-390

Belge Tipi:

Makale

Yayın Tarihi:

4/2002

Belge Dili:

Türkçe

Document ID (Org No.):

2000756898

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Meningitis

nitric oxide

sequela

prognosis

Sayı

Makale detayları

The Relation of Cerebrospinal Fluid Nitric Oxide Levels to Prognosis and Differential Diagnosis of Meningitis

Yazarlar: Kasım ÇETİN

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2002 Vol.32 Issue 5, pp.385-390

Belge Tipi: Makale

Yayın Tarihi: 4/2002

Belge Dili: Türkçe

Document ID (Org No.): 2000756898

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Meningitis

nitric oxide

sequela

prognosis

Sayı

Yazarlar:

Kasım ÇETİN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2002 Vol.32 Issue 5, pp.385-390

Belge Tipi:

Makale

Yayın Tarihi:

4/2002

Belge Dili:

Türkçe

Document ID (Org No.):

2000756898

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144