No major impact of insertion/deletion polymorphism of the angiotensin-converting enzyme gene on thyroid-associated ophthalmopathy

Seydi OKUMUŞ; Şeniz DEMİRYÜREK; Mehtap ÖZKUR; Erol COŞKUN

Makale detayları

No major impact of insertion/deletion polymorphism of the angiotensin-converting enzyme gene on thyroid-associated ophthalmopathy

Yazarlar:

Seydi OKUMUŞ | Şeniz DEMİRYÜREK | Mehtap ÖZKUR | Erol COŞKUN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2013 Vol.43 Issue 3, pp.436-440

Belge Tipi:

Makale

Yayın Tarihi:

2/2013

Belge Dili:

Türkçe

Document ID (Org No.):

2000753739

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

To investigate the association between ACE gene I/D polymorphism and thyroid-associated ophthalmopathy (TO) in the Turkish population.   Materials and methods: A total of 105 patients with TO and 102 healthy control subjects were enrolled in this case-control study. Genomic DNA was extracted from peripheral blood leukocytes, and I/D polymorphism of the ACE gene (ACE) was determined using a polymerase chain reaction.   Results: There were no marked changes in allelic frequencies and genotype distribution of ACE I/D polymorphism between patients and control subjects. The distribution of I/D polymorphism and allele frequencies of TO patients were not significantly different from those of the controls: DD genotype 34.3% vs. 41.2%; ID genotype 46.7% vs. 43.1%; and II genotype 19.0% vs. 15.7%; D allele 57.6% vs. 62.7%; I allele 42.4% vs. 37.3% (P > 0.05). Genotype and allele frequencies for men and women were also similar between the groups.  Conclusion: Our data suggest that ACE gene I/D polymorphism does not constitute a risk factor for TO in the Turkish population. Further studies using greater numbers of patients from different populations are required to clarify the role of the ACE gene in conferring susceptibility to TO.

 

To investigate the association between ACE gene I/D polymorphism and thyroid-associated ophthalmopathy (TO) in the Turkish population.   Materials and methods: A total of 105 patients with TO and 102 healthy control subjects were enrolled in this case-control study. Genomic DNA was extracted from peripheral blood leukocytes, and I/D polymorphism of the ACE gene (ACE) was determined using a polymerase chain reaction.   Results: There were no marked changes in allelic frequencies and genotype distribution of ACE I/D polymorphism between patients and control subjects. The distribution of I/D polymorphism and allele frequencies of TO patients were not significantly different from those of the controls: DD genotype 34.3% vs. 41.2%; ID genotype 46.7% vs. 43.1%; and II genotype 19.0% vs. 15.7%; D allele 57.6% vs. 62.7%; I allele 42.4% vs. 37.3% (P > 0.05). Genotype and allele frequencies for men and women were also similar between the groups.  Conclusion: Our data suggest that ACE gene I/D polymorphism does not constitute a risk factor for TO in the Turkish population. Further studies using greater numbers of patients from different populations are required to clarify the role of the ACE gene in conferring susceptibility to TO.

Makale detayları

No major impact of insertion/deletion polymorphism of the angiotensin-converting enzyme gene on thyroid-associated ophthalmopathy

Yazarlar:

Seydi OKUMUŞ | Şeniz DEMİRYÜREK | Mehtap ÖZKUR | Erol COŞKUN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2013 Vol.43 Issue 3, pp.436-440

Belge Tipi:

Makale

Yayın Tarihi:

2/2013

Belge Dili:

Türkçe

Document ID (Org No.):

2000753739

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Key words: ACE gene

allele frequency

I/D genotype

polymorphism

thyroid-associated ophthalmopathy

Sayı

Makale detayları

No major impact of insertion/deletion polymorphism of the angiotensin-converting enzyme gene on thyroid-associated ophthalmopathy

Yazarlar: Seydi OKUMUŞ | Şeniz DEMİRYÜREK | Mehtap ÖZKUR | Erol COŞKUN

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2013 Vol.43 Issue 3, pp.436-440

Belge Tipi: Makale

Yayın Tarihi: 2/2013

Belge Dili: Türkçe

Document ID (Org No.): 2000753739

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Key words: ACE gene

allele frequency

I/D genotype

polymorphism

thyroid-associated ophthalmopathy

Sayı

Yazarlar:

Seydi OKUMUŞ | Şeniz DEMİRYÜREK | Mehtap ÖZKUR | Erol COŞKUN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2013 Vol.43 Issue 3, pp.436-440

Belge Tipi:

Makale

Yayın Tarihi:

2/2013

Belge Dili:

Türkçe

Document ID (Org No.):

2000753739

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144