Investigation of Novel Hematological Index Variations in Cats Naturally Infected with Feline Panleukopenia Virus

Ömer Aydın

Makale detayları

Investigation of Novel Hematological Index Variations in Cats Naturally Infected with Feline Panleukopenia Virus

Yazarlar:

Ömer Aydın

Yayıncı:

Afyon Kocatepe University

Ana Başlıklar:

Veteriner İç Hastalıkları

Dergi:

Kocatepe Veteriner Dergisi Vol.18 Issue 1, pp.52-60

Belge Tipi:

Makale

Yayın Tarihi:

3/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001338457

pISSN:

1308-1594

Anahtar kelimeler:

Özet:

 Feline panleukopenia is a viral infection that impacts cats of all age groups, with particularly high mortality rates observed around the age of 3 months. The disease spreads through the fecal-oral transmission route. This study aims to evaluate the levels of various inflammatory hematologic indicesspecifically, the neutrophil-to-lymphocyte ratio NLR, platelet-to-lymphocyte ratio PLR, lymphocyte-to-monocyte ratio LMR, systemic inflammation response index SIRI, and systemic immune-inflammatory index SIIin cats naturally exposed to Feline Panleukopenia Virus FPV, and to assess the potential of these indices as markers of inflammation. Two groups were included in the study: a control group consisting of 20 healthy cats and an experimental group consisting of 40 cats showing symptoms of anorexia, vomiting, andor diarrhea, diagnosed with FPV using a rapid test kit. All cats in both groups were between 0 and 3 months old and represented a variety of breeds and genders. No significant differences were found between the groups for the NLR and LMR values with p-values of 0.054 and 0.627, respectively. However, the PLR was significantly higher in the FPV-infected group compared to the control group p0.001. In contrast, the SIRI p0.001 and SII p0.002 values were notably lower in the FPV-infected cats. In conclusion, this study revealed that there were significant differences in haematological indices between the two groups and PLR, SIRI and SII were important markers to reflect the inflammatory status in FPV infection.

 Feline panleukopenia is a viral infection that impacts cats of all age groups, with particularly high mortality rates observed around the age of 3 months. The disease spreads through the fecal-oral transmission route. This study aims to evaluate the levels of various inflammatory hematologic indicesspecifically, the neutrophil-to-lymphocyte ratio NLR, platelet-to-lymphocyte ratio PLR, lymphocyte-to-monocyte ratio LMR, systemic inflammation response index SIRI, and systemic immune-inflammatory index SIIin cats naturally exposed to Feline Panleukopenia Virus FPV, and to assess the potential of these indices as markers of inflammation. Two groups were included in the study: a control group consisting of 20 healthy cats and an experimental group consisting of 40 cats showing symptoms of anorexia, vomiting, andor diarrhea, diagnosed with FPV using a rapid test kit. All cats in both groups were between 0 and 3 months old and represented a variety of breeds and genders. No significant differences were found between the groups for the NLR and LMR values with p-values of 0.054 and 0.627, respectively. However, the PLR was significantly higher in the FPV-infected group compared to the control group p0.001. In contrast, the SIRI p0.001 and SII p0.002 values were notably lower in the FPV-infected cats. In conclusion, this study revealed that there were significant differences in haematological indices between the two groups and PLR, SIRI and SII were important markers to reflect the inflammatory status in FPV infection.

 Feline panleukopenia is a viral infection that impacts cats of all age groups, with particularly high mortality rates observed around the age of 3 months. The disease spreads through the fecal-oral transmission route. This study aims to evaluate the levels of various inflammatory hematologic indicesspecifically, the neutrophil-to-lymphocyte ratio NLR, platelet-to-lymphocyte ratio PLR, lymphocyte-to-monocyte ratio LMR, systemic inflammation response index SIRI, and systemic immune-inflammatory index SIIin cats naturally exposed to Feline Panleukopenia Virus FPV, and to assess the potential of these indices as markers of inflammation. Two groups were included in the study: a control group consisting of 20 healthy cats and an experimental group consisting of 40 cats showing symptoms of anorexia, vomiting, andor diarrhea, diagnosed with FPV using a rapid test kit. All cats in both groups were between 0 and 3 months old and represented a variety of breeds and genders. No significant differences were found between the groups for the NLR and LMR values with p-values of 0.054 and 0.627, respectively. However, the PLR was significantly higher in the FPV-infected group compared to the control group p0.001. In contrast, the SIRI p0.001 and SII p0.002 values were notably lower in the FPV-infected cats. In conclusion, this study revealed that there were significant differences in haematological indices between the two groups and PLR, SIRI and SII were important markers to reflect the inflammatory status in FPV infection.

 Feline panlökopeni, tüm yaş gruplarındaki kedileri etkileyen viral bir enfeksiyondur ve özellikle 3 aylık civarında yüksek ölüm oranları görülür. Hastalık fekal-oral bulaşma yolu ile yayılır. Bu çalışmanın amacı, doğal olarak Feline Panlökopeni Virüsüne FPV maruz kalan kedilerde çeşitli inflamatuar hematolojik indekslerin özellikle nötrofil-lenfosit oranı NLR, trombosit-lenfosit oranı PLR, lenfosit-monosit oranı LMR, sistemik inflamasyon yanıt indeksi SIRI ve sistemik immün-inflamatuar indeks SII düzeylerini ve bu indekslerin inflamasyon belirteçleri olarak potansiyelini değerlendirmektir. Çalışma 20 sağlıklı kediden oluşan bir kontrol grubu ve anoreksi, kusma veveya ishal semptomları gösteren ve hızlı test kitiyle FPV tanısı koyulmuş olan 40 kediden oluşan bir deney grubu olarak iki gruptan oluştu. Her iki gruptaki kediler 0 ila 3 aylık yaşta, çeşitli ırk ve cinsiyetlerden oluştu. Gruplar arasında NLR ve LMR değerleri açısından anlamlı bir fark bulunmamıştır p-değerleri sırasıyla 0,054 ve 0,627dir. Ancak, PLR değeri FPV ile enfekte grupta kontrol grubuna kıyasla anlamlı derecede yüksekti p0,001. Buna karşılık, SIRI p0,001 ve SII p0,002 değerleri FPV ile enfekte kedilerde belirgin şekilde daha düşüktü. Sonuç olarak, bu çalışma iki grup arasında hematolojik indekslerde önemli farklılıklar olduğunu ve PLR, SIRI ve SIInin FPV enfeksiyonunda inflamatuar durumu yansıtmada önemli belirteçler olduğunu ortaya koymuştur.

Makale detayları

Investigation of Novel Hematological Index Variations in Cats Naturally Infected with Feline Panleukopenia Virus

Yazarlar:

Ömer Aydın

Yayıncı:

Afyon Kocatepe University

Ana Başlıklar:

Veteriner İç Hastalıkları

Dergi:

Kocatepe Veteriner Dergisi Vol.18 Issue 1, pp.52-60

Belge Tipi:

Makale

Yayın Tarihi:

3/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001338457

pISSN:

1308-1594

Feline panleukopenia virus

Lymphocyte to monocyte ratio

Neutrophil to lymphocyte ratio

Systemic immune-inflammation index

Systemic inflammatory response indexFeline panlöpeni virüs

Lenfosit-monosit oranı

Nötrofil-lenfosit oranı

Sistemik immun inflamasyon indeksi

Sistemik inflamasyon yanıt indeksi

Sayı

Makale detayları

Yazarlar: Ömer Aydın

Yayıncı: Afyon Kocatepe University

Ana Başlıklar: Veteriner İç Hastalıkları

Dergi: Kocatepe Veteriner Dergisi Vol.18 Issue 1, pp.52-60

Belge Tipi: Makale

Yayın Tarihi: 3/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001338457

pISSN: 1308-1594

Sayı

Yazarlar:

Ömer Aydın

Yayıncı:

Afyon Kocatepe University

Ana Başlıklar:

Veteriner İç Hastalıkları

Dergi:

Kocatepe Veteriner Dergisi Vol.18 Issue 1, pp.52-60

Belge Tipi:

Makale

Yayın Tarihi:

3/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001338457

pISSN:

1308-1594