Spectrophotometric determination of Meloxicam in Pure Form and its Pharmaceutical Formulation following azo dye formation with 4-nitroaniline

Ali Atiyah

Makale detayları

Spectrophotometric determination of Meloxicam in Pure Form and its Pharmaceutical Formulation following azo dye formation with 4-nitroaniline

Yazarlar:

Ali Atiyah

Yayıncı:

Turkish Chemical Society

Ana Başlıklar:

Analytical Spectrometry

Dergi:

Journal of the Turkish Chemical Society Section A: Chemistry Vol.11 Issue 4, pp.1461-1472

Belge Tipi:

Makale

Yayın Tarihi:

3/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001327165

pISSN:

2149-0120

Anahtar kelimeler:

Özet:

 A fast, cheap, and straightforward spectrophotometric method has been proposed to determine meloxicam MEL in its pure form and pharmaceutical formulation. The technique involves diazotizing the NH2 group in 4-nitroaniline with NaNO2 followed by a reaction with meloxicam to produce a stable and colored complex in a basic medium. This complex demonstrates maximum absorbance at 514 nm. The developed methods linearity ranges from 2.0 - 25 μg mL-1, and the molar absorptivity is 1.5989104 L mol-1 cm-1. The RSD is lower than 1.55. Additionally, the limit of detection LOD is 0.2019 μg mL-1. The method successfully determines the pharmaceutical preparation containing meloxicam Loxim tablets with a recovery rate of no less than 97.9.

 A fast, cheap, and straightforward spectrophotometric method has been proposed to determine meloxicam MEL in its pure form and pharmaceutical formulation. The technique involves diazotizing the NH2 group in 4-nitroaniline with NaNO2 followed by a reaction with meloxicam to produce a stable and colored complex in a basic medium. This complex demonstrates maximum absorbance at 514 nm. The developed methods linearity ranges from 2.0 - 25 μg mL-1, and the molar absorptivity is 1.5989104 L mol-1 cm-1. The RSD is lower than 1.55. Additionally, the limit of detection LOD is 0.2019 μg mL-1. The method successfully determines the pharmaceutical preparation containing meloxicam Loxim tablets with a recovery rate of no less than 97.9.

 A fast, cheap, and straightforward spectrophotometric method has been proposed to determine meloxicam MEL in its pure form and pharmaceutical formulation. The technique involves diazotizing the NH2 group in 4-nitroaniline with NaNO2 followed by a reaction with meloxicam to produce a stable and colored complex in a basic medium. This complex demonstrates maximum absorbance at 514 nm. The developed methods linearity ranges from 2.0 - 25 μg mL-1, and the molar absorptivity is 1.5989104 L mol-1 cm-1. The RSD is lower than 1.55. Additionally, the limit of detection LOD is 0.2019 μg mL-1. The method successfully determines the pharmaceutical preparation containing meloxicam Loxim tablets with a recovery rate of no less than 97.9.

 A fast, cheap, and straightforward spectrophotometric method has been proposed to determine meloxicam MEL in its pure form and pharmaceutical formulation. The technique involves diazotizing the NH2 group in 4-nitroaniline with NaNO2 followed by a reaction with meloxicam to produce a stable and colored complex in a basic medium. This complex demonstrates maximum absorbance at 514 nm. The developed methods linearity ranges from 2.0 - 25 μg mL-1, and the molar absorptivity is 1.5989104 L mol-1 cm-1. The RSD is lower than 1.55. Additionally, the limit of detection LOD is 0.2019 μg mL-1. The method successfully determines the pharmaceutical preparation containing meloxicam Loxim tablets with a recovery rate of no less than 97.9.

Makale detayları

Spectrophotometric determination of Meloxicam in Pure Form and its Pharmaceutical Formulation following azo dye formation with 4-nitroaniline

Yazarlar:

Ali Atiyah

Yayıncı:

Turkish Chemical Society

Ana Başlıklar:

Analytical Spectrometry

Dergi:

Journal of the Turkish Chemical Society Section A: Chemistry Vol.11 Issue 4, pp.1461-1472

Belge Tipi:

Makale

Yayın Tarihi:

3/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001327165

pISSN:

2149-0120

Spectrophotometric

Diazotization coupling reaction

Meloxicam

4-Nitroaniline

Sayı

Makale detayları

Spectrophotometric determination of Meloxicam in Pure Form and its Pharmaceutical Formulation following azo dye formation with 4-nitroaniline

Yazarlar: Ali Atiyah

Yayıncı: Turkish Chemical Society

Ana Başlıklar: Analytical Spectrometry

Dergi: Journal of the Turkish Chemical Society Section A: Chemistry Vol.11 Issue 4, pp.1461-1472

Belge Tipi: Makale

Yayın Tarihi: 3/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001327165

pISSN: 2149-0120

Spectrophotometric

Diazotization coupling reaction

Meloxicam

4-Nitroaniline

Sayı

Yazarlar:

Ali Atiyah

Yayıncı:

Turkish Chemical Society

Ana Başlıklar:

Analytical Spectrometry

Dergi:

Journal of the Turkish Chemical Society Section A: Chemistry Vol.11 Issue 4, pp.1461-1472

Belge Tipi:

Makale

Yayın Tarihi:

3/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001327165

pISSN:

2149-0120