Evaluation of the effect of isotretinoin on salivary gland function by Tc-99m pertechnetate imaging in acne vulgaris patients

Ebru ÖRSAL; Bedri SEVEN; Mustafa Teoman ERDEM; Erhan VAROĞLU; Hatice FARIMAZ; Arif Kürşad AYAN

Makale detayları

Evaluation of the effect of isotretinoin on salivary gland function by Tc-99m pertechnetate imaging in acne vulgaris patients

Yazarlar:

Ebru ÖRSAL | Bedri SEVEN | Mustafa Teoman ERDEM | Erhan VAROĞLU | Hatice FARIMAZ | Arif Kürşad AYAN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2015 Vol.45 Issue 3, pp.674-677

Belge Tipi:

Makale

Yayın Tarihi:

8/2015

Belge Dili:

Türkçe

Document ID (Org No.):

2000752713

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

Background/aim: Isotretinoin is an effective drug utilized in the management of acne vulgaris and is known to cause dry mouth. In this study, we aimed to evaluate this effect of isotretinoin on the salivary gland function in patients with acne vulgaris using technetium-99m (Tc-99m) pertechnetate imaging of the salivary glands.   Materials and methods: The study population consisted of 28 patients with acne vulgaris (6 males and 22 females, mean age 20.2 ± 2.3 years), who were treated with isotretinoin for 6 months. We performed radionuclide imaging of the salivary glands pretreatment and at months 3 and 6 of treatment. After 185 MBq (5 mCi) of Tc-99m pertechnetate was intravenously administered, imaging of the salivary glands was performed over a 25-min period. We measured the following glandular function parameters for the parotid and submandibular salivary glands via time-activity curves: uptake ratio, maximum accumulation, and ejection fraction.   Results: Statistically significant differences were observed in the values obtained at months 3 and 6 of treatment, compared with the pretreatment values.   Conclusion: This study demonstrated that radionuclide imaging of the salivary glands can clearly show the glandular functions that are affected by drugs such as isotretinoin.

 

Background/aim: Isotretinoin is an effective drug utilized in the management of acne vulgaris and is known to cause dry mouth. In this study, we aimed to evaluate this effect of isotretinoin on the salivary gland function in patients with acne vulgaris using technetium-99m (Tc-99m) pertechnetate imaging of the salivary glands.   Materials and methods: The study population consisted of 28 patients with acne vulgaris (6 males and 22 females, mean age 20.2 ± 2.3 years), who were treated with isotretinoin for 6 months. We performed radionuclide imaging of the salivary glands pretreatment and at months 3 and 6 of treatment. After 185 MBq (5 mCi) of Tc-99m pertechnetate was intravenously administered, imaging of the salivary glands was performed over a 25-min period. We measured the following glandular function parameters for the parotid and submandibular salivary glands via time-activity curves: uptake ratio, maximum accumulation, and ejection fraction.   Results: Statistically significant differences were observed in the values obtained at months 3 and 6 of treatment, compared with the pretreatment values.   Conclusion: This study demonstrated that radionuclide imaging of the salivary glands can clearly show the glandular functions that are affected by drugs such as isotretinoin.

Makale detayları

Evaluation of the effect of isotretinoin on salivary gland function by Tc-99m pertechnetate imaging in acne vulgaris patients

Yazarlar:

Ebru ÖRSAL | Bedri SEVEN | Mustafa Teoman ERDEM | Erhan VAROĞLU | Hatice FARIMAZ | Arif Kürşad AYAN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2015 Vol.45 Issue 3, pp.674-677

Belge Tipi:

Makale

Yayın Tarihi:

8/2015

Belge Dili:

Türkçe

Document ID (Org No.):

2000752713

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Radionuclide imaging of salivary glands

technetium-99m pertechnetate

isotretinoin

acne vulgaris

Sayı

Makale detayları

Evaluation of the effect of isotretinoin on salivary gland function by Tc-99m pertechnetate imaging in acne vulgaris patients

Yazarlar: Ebru ÖRSAL | Bedri SEVEN | Mustafa Teoman ERDEM | Erhan VAROĞLU | Hatice FARIMAZ | Arif Kürşad AYAN

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2015 Vol.45 Issue 3, pp.674-677

Belge Tipi: Makale

Yayın Tarihi: 8/2015

Belge Dili: Türkçe

Document ID (Org No.): 2000752713

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Radionuclide imaging of salivary glands

technetium-99m pertechnetate

isotretinoin

acne vulgaris

Sayı

Yazarlar:

Ebru ÖRSAL | Bedri SEVEN | Mustafa Teoman ERDEM | Erhan VAROĞLU | Hatice FARIMAZ | Arif Kürşad AYAN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2015 Vol.45 Issue 3, pp.674-677

Belge Tipi:

Makale

Yayın Tarihi:

8/2015

Belge Dili:

Türkçe

Document ID (Org No.):

2000752713

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144