An Essential Problem in Patients with Hereditary Angioedema: Irritable Bowel Syndrome

Mehmet Kılınç; Fatih Çölkesen; Filiz Sadi Aykan; Recep Evcen; Eray Yıldız; Tuğba Önalan; Mehmet Emin Gerek; Şevket Arslan

Makale detayları

An Essential Problem in Patients with Hereditary Angioedema: Irritable Bowel Syndrome

Yazarlar:

Mehmet Kılınç | Fatih Çölkesen | Filiz Sadi Aykan | Recep Evcen | Eray Yıldız | Tuğba Önalan | Mehmet Emin Gerek | Şevket Arslan

Yayıncı:

Süleyman Demirel University

Ana Başlıklar:

Allergy

Dergi:

Medical Journal of Süleyman Demirel University Vol.31 Issue 3, pp.229-234

Belge Tipi:

Makale

Yayın Tarihi:

9/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001327877

pISSN:

1300-7416

Anahtar kelimeler:

Özet:

 Objective: Hereditary angioedema HAE is characterized by attacks of subcutaneous and mucosal edema. HAE usually affects the skin or mucosal tissues of the upper respiratory and gastrointestinal tract. Irritable bowel syndrome IBS is one of the diseases in which the abdominal symptoms of HAE may be confused. In this study, we aimed to clarify the role of IBS in clinical presentation and diagnostic delay in HAE. Material and Method: 50 patients with HAE followed in our clinic between January 2013 and April 2023 were included in this study, and hospital records were retrospectively reviewed. Patients with HAE were divided into two groups, those with and without IBS, and evaluated according to Rome IV criteria for diagnosing IBS. Results: The mean age of the study group was 40  13 years, and 60 n30 were female. IBS was observed in 30 n15 of the patients, and 60 n9 had IBS before diagnosing HAE. The frequency of attacks and history of gastrointestinal tract medicalsurgical history were more frequent in HAE patients with IBS p0.001, p0.032, respectively. Abdominal symptoms before the diagnosis of HAE and persistent abdominal symptoms other than attacks after the diagnosis of HAE were more common in HAE patients with IBS p0.001, p0.001, respectively. HAE patients with IBS had a more significant delay in diagnosing HAE p0.011. Conclusion: Clinicians should keep HAE in mind in patients with suspected IBS or patients presenting with recurrent unexplained abdominal pain.

 Objective: Hereditary angioedema HAE is characterized by attacks of subcutaneous and mucosal edema. HAE usually affects the skin or mucosal tissues of the upper respiratory and gastrointestinal tract. Irritable bowel syndrome IBS is one of the diseases in which the abdominal symptoms of HAE may be confused. In this study, we aimed to clarify the role of IBS in clinical presentation and diagnostic delay in HAE. Material and Method: 50 patients with HAE followed in our clinic between January 2013 and April 2023 were included in this study, and hospital records were retrospectively reviewed. Patients with HAE were divided into two groups, those with and without IBS, and evaluated according to Rome IV criteria for diagnosing IBS. Results: The mean age of the study group was 40  13 years, and 60 n30 were female. IBS was observed in 30 n15 of the patients, and 60 n9 had IBS before diagnosing HAE. The frequency of attacks and history of gastrointestinal tract medicalsurgical history were more frequent in HAE patients with IBS p0.001, p0.032, respectively. Abdominal symptoms before the diagnosis of HAE and persistent abdominal symptoms other than attacks after the diagnosis of HAE were more common in HAE patients with IBS p0.001, p0.001, respectively. HAE patients with IBS had a more significant delay in diagnosing HAE p0.011. Conclusion: Clinicians should keep HAE in mind in patients with suspected IBS or patients presenting with recurrent unexplained abdominal pain.

 Objective: Hereditary angioedema HAE is characterized by attacks of subcutaneous and mucosal edema. HAE usually affects the skin or mucosal tissues of the upper respiratory and gastrointestinal tract. Irritable bowel syndrome IBS is one of the diseases in which the abdominal symptoms of HAE may be confused. In this study, we aimed to clarify the role of IBS in clinical presentation and diagnostic delay in HAE. Material and Method: 50 patients with HAE followed in our clinic between January 2013 and April 2023 were included in this study, and hospital records were retrospectively reviewed. Patients with HAE were divided into two groups, those with and without IBS, and evaluated according to Rome IV criteria for diagnosing IBS. Results: The mean age of the study group was 40  13 years, and 60 n30 were female. IBS was observed in 30 n15 of the patients, and 60 n9 had IBS before diagnosing HAE. The frequency of attacks and history of gastrointestinal tract medicalsurgical history were more frequent in HAE patients with IBS p0.001, p0.032, respectively. Abdominal symptoms before the diagnosis of HAE and persistent abdominal symptoms other than attacks after the diagnosis of HAE were more common in HAE patients with IBS p0.001, p0.001, respectively. HAE patients with IBS had a more significant delay in diagnosing HAE p0.011. Conclusion: Clinicians should keep HAE in mind in patients with suspected IBS or patients presenting with recurrent unexplained abdominal pain.

 Objective: Hereditary angioedema HAE is characterized by attacks of subcutaneous and mucosal edema. HAE usually affects the skin or mucosal tissues of the upper respiratory and gastrointestinal tract. Irritable bowel syndrome IBS is one of the diseases in which the abdominal symptoms of HAE may be confused. In this study, we aimed to clarify the role of IBS in clinical presentation and diagnostic delay in HAE. Material and Method: 50 patients with HAE followed in our clinic between January 2013 and April 2023 were included in this study, and hospital records were retrospectively reviewed. Patients with HAE were divided into two groups, those with and without IBS, and evaluated according to Rome IV criteria for diagnosing IBS. Results: The mean age of the study group was 40  13 years, and 60 n30 were female. IBS was observed in 30 n15 of the patients, and 60 n9 had IBS before diagnosing HAE. The frequency of attacks and history of gastrointestinal tract medicalsurgical history were more frequent in HAE patients with IBS p0.001, p0.032, respectively. Abdominal symptoms before the diagnosis of HAE and persistent abdominal symptoms other than attacks after the diagnosis of HAE were more common in HAE patients with IBS p0.001, p0.001, respectively. HAE patients with IBS had a more significant delay in diagnosing HAE p0.011. Conclusion: Clinicians should keep HAE in mind in patients with suspected IBS or patients presenting with recurrent unexplained abdominal pain.

Makale detayları

An Essential Problem in Patients with Hereditary Angioedema: Irritable Bowel Syndrome

Yazarlar:

Mehmet Kılınç | Fatih Çölkesen | Filiz Sadi Aykan | Recep Evcen | Eray Yıldız | Tuğba Önalan | Mehmet Emin Gerek | Şevket Arslan

Yayıncı:

Süleyman Demirel University

Ana Başlıklar:

Allergy

Dergi:

Medical Journal of Süleyman Demirel University Vol.31 Issue 3, pp.229-234

Belge Tipi:

Makale

Yayın Tarihi:

9/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001327877

pISSN:

1300-7416

Hereditary angioedema

irritable bowel syndrome

abdominal symptoms

frequent attacks

diagnostic delay.

Sayı

Makale detayları

An Essential Problem in Patients with Hereditary Angioedema: Irritable Bowel Syndrome

Yazarlar: Mehmet Kılınç | Fatih Çölkesen | Filiz Sadi Aykan | Recep Evcen | Eray Yıldız | Tuğba Önalan | Mehmet Emin Gerek | Şevket Arslan

Yayıncı: Süleyman Demirel University

Ana Başlıklar: Allergy

Dergi: Medical Journal of Süleyman Demirel University Vol.31 Issue 3, pp.229-234

Belge Tipi: Makale

Yayın Tarihi: 9/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001327877

pISSN: 1300-7416

Hereditary angioedema

irritable bowel syndrome

abdominal symptoms

frequent attacks

diagnostic delay.

Sayı

Yazarlar:

Mehmet Kılınç | Fatih Çölkesen | Filiz Sadi Aykan | Recep Evcen | Eray Yıldız | Tuğba Önalan | Mehmet Emin Gerek | Şevket Arslan

Yayıncı:

Süleyman Demirel University

Ana Başlıklar:

Allergy

Dergi:

Medical Journal of Süleyman Demirel University Vol.31 Issue 3, pp.229-234

Belge Tipi:

Makale

Yayın Tarihi:

9/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001327877

pISSN:

1300-7416