Mechanism of antinociceptive action of syringic acid

Mehmet Evren Okur; Ayşe Arzu Şakul

Makale detayları

Mechanism of antinociceptive action of syringic acid

Yazarlar:

Mehmet Evren Okur | Ayşe Arzu Şakul

Yayıncı:

Marmara University

Ana Başlıklar:

Basic Pharmacology | Medical Pharmacology

Dergi:

Journal of Research in Pharmacy Vol.25 Issue 3, pp.277-286

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347919

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 Syringic acid presents various biological properties such as antioxidant, anti-inflammatory, anticancer, and other activities. The present experiment aimed to investigate the effect of the oral administration of syringic acid 10, 50, and 100 mgkg on its possible nociceptive response using hot-plate and tail-flick assay in the Balb-C mice model. The mice were pre-treated with 5 mgkg atropine 15 min before, 1mgkg mecamylamine 20 min before, 1mgkg ketanserin 30 min before, 1 mgkg ondansetron 30 min before, 1mgkg yohimbine 30 min before, 1 mgkg prazosin 30 min before and 5 mgkg naloxone 15min before the administration of the Syringic acid. Dose-dependent antinociceptive activity of syringic acid was reported for 50 and 100 mgkg doses in tail-flick and hot-plate assays, respectively. In further, mecamylamine, yohimbine, and naloxone significantly reversed syringic acid-induced response to thermal stimuli in tail-flick and hot-plate assays, respectively. From the data, it was confirmed that syringic acid presents central antinociceptive effects which may be coordinated by supraspinalspinal mediated cholinergic, opioidergic, and adrenergic, inflection.

 Syringic acid presents various biological properties such as antioxidant, anti-inflammatory, anticancer, and other activities. The present experiment aimed to investigate the effect of the oral administration of syringic acid 10, 50, and 100 mgkg on its possible nociceptive response using hot-plate and tail-flick assay in the Balb-C mice model. The mice were pre-treated with 5 mgkg atropine 15 min before, 1mgkg mecamylamine 20 min before, 1mgkg ketanserin 30 min before, 1 mgkg ondansetron 30 min before, 1mgkg yohimbine 30 min before, 1 mgkg prazosin 30 min before and 5 mgkg naloxone 15min before the administration of the Syringic acid. Dose-dependent antinociceptive activity of syringic acid was reported for 50 and 100 mgkg doses in tail-flick and hot-plate assays, respectively. In further, mecamylamine, yohimbine, and naloxone significantly reversed syringic acid-induced response to thermal stimuli in tail-flick and hot-plate assays, respectively. From the data, it was confirmed that syringic acid presents central antinociceptive effects which may be coordinated by supraspinalspinal mediated cholinergic, opioidergic, and adrenergic, inflection.

 Syringic acid presents various biological properties such as antioxidant, anti-inflammatory, anticancer, and other activities. The present experiment aimed to investigate the effect of the oral administration of syringic acid 10, 50, and 100 mgkg on its possible nociceptive response using hot-plate and tail-flick assay in the Balb-C mice model. The mice were pre-treated with 5 mgkg atropine 15 min before, 1mgkg mecamylamine 20 min before, 1mgkg ketanserin 30 min before, 1 mgkg ondansetron 30 min before, 1mgkg yohimbine 30 min before, 1 mgkg prazosin 30 min before and 5 mgkg naloxone 15min before the administration of the Syringic acid. Dose-dependent antinociceptive activity of syringic acid was reported for 50 and 100 mgkg doses in tail-flick and hot-plate assays, respectively. In further, mecamylamine, yohimbine, and naloxone significantly reversed syringic acid-induced response to thermal stimuli in tail-flick and hot-plate assays, respectively. From the data, it was confirmed that syringic acid presents central antinociceptive effects which may be coordinated by supraspinalspinal mediated cholinergic, opioidergic, and adrenergic, inflection.

 Syringic acid presents various biological properties such as antioxidant, anti-inflammatory, anticancer, and other activities. The present experiment aimed to investigate the effect of the oral administration of syringic acid 10, 50, and 100 mgkg on its possible nociceptive response using hot-plate and tail-flick assay in the Balb-C mice model. The mice were pre-treated with 5 mgkg atropine 15 min before, 1mgkg mecamylamine 20 min before, 1mgkg ketanserin 30 min before, 1 mgkg ondansetron 30 min before, 1mgkg yohimbine 30 min before, 1 mgkg prazosin 30 min before and 5 mgkg naloxone 15min before the administration of the Syringic acid. Dose-dependent antinociceptive activity of syringic acid was reported for 50 and 100 mgkg doses in tail-flick and hot-plate assays, respectively. In further, mecamylamine, yohimbine, and naloxone significantly reversed syringic acid-induced response to thermal stimuli in tail-flick and hot-plate assays, respectively. From the data, it was confirmed that syringic acid presents central antinociceptive effects which may be coordinated by supraspinalspinal mediated cholinergic, opioidergic, and adrenergic, inflection.

Makale detayları

Mechanism of antinociceptive action of syringic acid

Yazarlar:

Mehmet Evren Okur | Ayşe Arzu Şakul

Yayıncı:

Marmara University

Ana Başlıklar:

Basic Pharmacology | Medical Pharmacology

Dergi:

Journal of Research in Pharmacy Vol.25 Issue 3, pp.277-286

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347919

pISSN:

2630-6344

Antinociception

muscarinic receptors

opioidergic receptors

α2-adrenoceptors

syringic acid.

Sayı

Makale detayları

Mechanism of antinociceptive action of syringic acid

Yazarlar: Mehmet Evren Okur | Ayşe Arzu Şakul

Yayıncı: Marmara University

Ana Başlıklar: Basic Pharmacology | Medical Pharmacology

Dergi: Journal of Research in Pharmacy Vol.25 Issue 3, pp.277-286

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001347919

pISSN: 2630-6344

Antinociception

muscarinic receptors

opioidergic receptors

α2-adrenoceptors

syringic acid.

Sayı

Yazarlar:

Mehmet Evren Okur | Ayşe Arzu Şakul

Yayıncı:

Marmara University

Ana Başlıklar:

Basic Pharmacology | Medical Pharmacology

Dergi:

Journal of Research in Pharmacy Vol.25 Issue 3, pp.277-286

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347919

pISSN:

2630-6344