The protective impact of glutamine on anti-tuberculosis drug-induced nephrotoxicity in Wistar rats

Elias Adıkwu; Martins Mbonu; Tobechi Brendan Nnanna

Makale detayları

The protective impact of glutamine on anti-tuberculosis drug-induced nephrotoxicity in Wistar rats

Yazarlar:

Elias Adıkwu | Martins Mbonu | Tobechi Brendan Nnanna

Yayıncı:

Ondokuz Mayıs University

Ana Başlıklar:

Health Care Administration

Dergi:

Deneysel ve Klinik Tıp Dergisi Vol.40 Issue 1, pp.7-12

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001285206

pISSN:

1309-4483

Anahtar kelimeler:

Özet:

 This study assessed the protective effect of glutamine GTN against rifampicinisoniazidpyrazinamideethambutol RIPE-induced nephrotoxicity in rats. Thirty adult Wistar rats 20020 g of both sexes were grouped into 6 of 5 ratsgroup. The rats were treated daily for 30 days as follows: Group 1 Vehicle control normal saline 0.2mL, group 2 GTN 200 mgkg, group 3 RIPE 150, 75, 400 and 275 mgkg in vehicle, group 4 GTN 50 mgkg RIPE, group 5 GTN 100 mgkg RIPE and group 6 GTN 200 mgkg RIPE. After treatment, blood samples were obtained and assessed for serum renal biomarkers. Kidneys were harvested, weighed and assessed for oxidative stress markers and histology. RIPE significantly p0.01 decreased body weight and significantly p0.01 increased kidney weight when compared to the control. Serum urea, creatinine, uric acid levels and kidney malondialdehyde levels were significantly p0.001 increased in RIPE-treated rats when compared to the control. Serum total protein, albumin, kidney glutathione, catalase, superoxide dismutase and glutathione peroxidase levels were significantly decreased p0.001 in RIPE-treated rats when compared to the control. RIPE caused tubular necrosis and collapsed glomeruli in the kidneys of rats. However, body and liver weights were significantly restored in GTN 100 mgkg RIPE and GTN 200 mgkg RIPE-treated rats at p0.05 and p0.01, respectively when compared to RIPE. Serum and kidney oxidative stress markers were restored in GTN 50 mgkg RIPE, GTN 100 mgkg RIPE and GTN 200 mgkg RIPE-treated rats at p0.05, p0.01 and p0.001 respectively, when compared to RIPE. GTN restored kidney histology. GTN protects against RIPE-induced nephrotoxicity in a dose-related fashion.

 This study assessed the protective effect of glutamine GTN against rifampicinisoniazidpyrazinamideethambutol RIPE-induced nephrotoxicity in rats. Thirty adult Wistar rats 20020 g of both sexes were grouped into 6 of 5 ratsgroup. The rats were treated daily for 30 days as follows: Group 1 Vehicle control normal saline 0.2mL, group 2 GTN 200 mgkg, group 3 RIPE 150, 75, 400 and 275 mgkg in vehicle, group 4 GTN 50 mgkg RIPE, group 5 GTN 100 mgkg RIPE and group 6 GTN 200 mgkg RIPE. After treatment, blood samples were obtained and assessed for serum renal biomarkers. Kidneys were harvested, weighed and assessed for oxidative stress markers and histology. RIPE significantly p0.01 decreased body weight and significantly p0.01 increased kidney weight when compared to the control. Serum urea, creatinine, uric acid levels and kidney malondialdehyde levels were significantly p0.001 increased in RIPE-treated rats when compared to the control. Serum total protein, albumin, kidney glutathione, catalase, superoxide dismutase and glutathione peroxidase levels were significantly decreased p0.001 in RIPE-treated rats when compared to the control. RIPE caused tubular necrosis and collapsed glomeruli in the kidneys of rats. However, body and liver weights were significantly restored in GTN 100 mgkg RIPE and GTN 200 mgkg RIPE-treated rats at p0.05 and p0.01, respectively when compared to RIPE. Serum and kidney oxidative stress markers were restored in GTN 50 mgkg RIPE, GTN 100 mgkg RIPE and GTN 200 mgkg RIPE-treated rats at p0.05, p0.01 and p0.001 respectively, when compared to RIPE. GTN restored kidney histology. GTN protects against RIPE-induced nephrotoxicity in a dose-related fashion.

 This study assessed the protective effect of glutamine GTN against rifampicinisoniazidpyrazinamideethambutol RIPE-induced nephrotoxicity in rats. Thirty adult Wistar rats 20020 g of both sexes were grouped into 6 of 5 ratsgroup. The rats were treated daily for 30 days as follows: Group 1 Vehicle control normal saline 0.2mL, group 2 GTN 200 mgkg, group 3 RIPE 150, 75, 400 and 275 mgkg in vehicle, group 4 GTN 50 mgkg RIPE, group 5 GTN 100 mgkg RIPE and group 6 GTN 200 mgkg RIPE. After treatment, blood samples were obtained and assessed for serum renal biomarkers. Kidneys were harvested, weighed and assessed for oxidative stress markers and histology. RIPE significantly p0.01 decreased body weight and significantly p0.01 increased kidney weight when compared to the control. Serum urea, creatinine, uric acid levels and kidney malondialdehyde levels were significantly p0.001 increased in RIPE-treated rats when compared to the control. Serum total protein, albumin, kidney glutathione, catalase, superoxide dismutase and glutathione peroxidase levels were significantly decreased p0.001 in RIPE-treated rats when compared to the control. RIPE caused tubular necrosis and collapsed glomeruli in the kidneys of rats. However, body and liver weights were significantly restored in GTN 100 mgkg RIPE and GTN 200 mgkg RIPE-treated rats at p0.05 and p0.01, respectively when compared to RIPE. Serum and kidney oxidative stress markers were restored in GTN 50 mgkg RIPE, GTN 100 mgkg RIPE and GTN 200 mgkg RIPE-treated rats at p0.05, p0.01 and p0.001 respectively, when compared to RIPE. GTN restored kidney histology. GTN protects against RIPE-induced nephrotoxicity in a dose-related fashion.

 This study assessed the protective effect of glutamine GTN against rifampicinisoniazidpyrazinamideethambutol RIPE-induced nephrotoxicity in rats. Thirty adult Wistar rats 20020 g of both sexes were grouped into 6 of 5 ratsgroup. The rats were treated daily for 30 days as follows: Group 1 Vehicle control normal saline 0.2mL, group 2 GTN 200 mgkg, group 3 RIPE 150, 75, 400 and 275 mgkg in vehicle, group 4 GTN 50 mgkg RIPE, group 5 GTN 100 mgkg RIPE and group 6 GTN 200 mgkg RIPE. After treatment, blood samples were obtained and assessed for serum renal biomarkers. Kidneys were harvested, weighed and assessed for oxidative stress markers and histology. RIPE significantly p0.01 decreased body weight and significantly p0.01 increased kidney weight when compared to the control. Serum urea, creatinine, uric acid levels and kidney malondialdehyde levels were significantly p0.001 increased in RIPE-treated rats when compared to the control. Serum total protein, albumin, kidney glutathione, catalase, superoxide dismutase and glutathione peroxidase levels were significantly decreased p0.001 in RIPE-treated rats when compared to the control. RIPE caused tubular necrosis and collapsed glomeruli in the kidneys of rats. However, body and liver weights were significantly restored in GTN 100 mgkg RIPE and GTN 200 mgkg RIPE-treated rats at p0.05 and p0.01, respectively when compared to RIPE. Serum and kidney oxidative stress markers were restored in GTN 50 mgkg RIPE, GTN 100 mgkg RIPE and GTN 200 mgkg RIPE-treated rats at p0.05, p0.01 and p0.001 respectively, when compared to RIPE. GTN restored kidney histology. GTN protects against RIPE-induced nephrotoxicity in a dose-related fashion.

Makale detayları

The protective impact of glutamine on anti-tuberculosis drug-induced nephrotoxicity in Wistar rats

Yazarlar:

Elias Adıkwu | Martins Mbonu | Tobechi Brendan Nnanna

Yayıncı:

Ondokuz Mayıs University

Ana Başlıklar:

Health Care Administration

Dergi:

Deneysel ve Klinik Tıp Dergisi Vol.40 Issue 1, pp.7-12

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001285206

pISSN:

1309-4483

Antituberculosis drug

kidney

toxicity

glutamine

prevention

rat

Sayı

Makale detayları

The protective impact of glutamine on anti-tuberculosis drug-induced nephrotoxicity in Wistar rats

Yazarlar: Elias Adıkwu | Martins Mbonu | Tobechi Brendan Nnanna

Yayıncı: Ondokuz Mayıs University

Ana Başlıklar: Health Care Administration

Dergi: Deneysel ve Klinik Tıp Dergisi Vol.40 Issue 1, pp.7-12

Belge Tipi: Makale

Yayın Tarihi: 3/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001285206

pISSN: 1309-4483

Antituberculosis drug

kidney

toxicity

glutamine

prevention

rat

Sayı

Yazarlar:

Elias Adıkwu | Martins Mbonu | Tobechi Brendan Nnanna

Yayıncı:

Ondokuz Mayıs University

Ana Başlıklar:

Health Care Administration

Dergi:

Deneysel ve Klinik Tıp Dergisi Vol.40 Issue 1, pp.7-12

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001285206

pISSN:

1309-4483