Novel Analogues of 2-Pyrazoline: Synthesis, Characterization, and Antimycobacterial Evaluation

Ahmet ÖZDEMİR; Gülhan TURAN-ZITOUNI; Zafer Asım KAPLANCIKLI

Makale detayları

Novel Analogues of 2-Pyrazoline: Synthesis, Characterization, and Antimycobacterial Evaluation

Yazarlar:

Ahmet ÖZDEMİR | Gülhan TURAN-ZITOUNI | Zafer Asım KAPLANCIKLI

Yayıncı:

TUBITAK

Ana Başlıklar:

Uygulamalı fizik

Dergi:

Turkish Journal of Chemistry 2008 Vol.32 Issue 5, pp.529-538

Belge Tipi:

Makale

Yayın Tarihi:

4/2008

Belge Dili:

İngilizce

Document ID (Org No.):

2000728428

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

Özet:

 

Fourteen new 1-[(N,N-disubstitutedthiocarbamoylthio)acetyl]-  3-(2-thienyl)-5-aryl-2-pyrazoline derivatives were synthesized by  reacting 1-(chloroacetyl)-3-(2-thienyl)-5-aryl-2-pyrazolines and  appropriate sodium salts of N,N-disubstituted dithiocarbamoic acids in  acetone.  The structures of the synthesized compounds were confirmed  by UV, IR, 1H-NMR, and FAB+-MS spectral data.  The compounds were  evaluated for in vitro antimycobacterial activity against  Mycobacterium tuberculosis H37Rv using the BACTEC 460 radiometric  system and BACTEC 12B medium.  The preliminary results showed that all  of the tested compounds were inactive against the test organism.

 

Fourteen new 1-[(N,N-disubstitutedthiocarbamoylthio)acetyl]-  3-(2-thienyl)-5-aryl-2-pyrazoline derivatives were synthesized by  reacting 1-(chloroacetyl)-3-(2-thienyl)-5-aryl-2-pyrazolines and  appropriate sodium salts of N,N-disubstituted dithiocarbamoic acids in  acetone.  The structures of the synthesized compounds were confirmed  by UV, IR, 1H-NMR, and FAB+-MS spectral data.  The compounds were  evaluated for in vitro antimycobacterial activity against  Mycobacterium tuberculosis H37Rv using the BACTEC 460 radiometric  system and BACTEC 12B medium.  The preliminary results showed that all  of the tested compounds were inactive against the test organism.

Makale detayları

Novel Analogues of 2-Pyrazoline: Synthesis, Characterization, and Antimycobacterial Evaluation

Yazarlar: Ahmet ÖZDEMİR | Gülhan TURAN-ZITOUNI | Zafer Asım KAPLANCIKLI

Yayıncı: TUBITAK

Ana Başlıklar: Uygulamalı fizik

Dergi: Turkish Journal of Chemistry 2008 Vol.32 Issue 5, pp.529-538

Belge Tipi: Makale

Yayın Tarihi: 4/2008

Belge Dili: İngilizce

Document ID (Org No.): 2000728428

Sıklık: İki Aylık

eISSN: 1303-6130

pISSN: 1300-0527

Sayı

Yazarlar:

Ahmet ÖZDEMİR | Gülhan TURAN-ZITOUNI | Zafer Asım KAPLANCIKLI

Yayıncı:

TUBITAK

Ana Başlıklar:

Uygulamalı fizik

Dergi:

Turkish Journal of Chemistry 2008 Vol.32 Issue 5, pp.529-538

Belge Tipi:

Makale

Yayın Tarihi:

4/2008

Belge Dili:

İngilizce

Document ID (Org No.):

2000728428

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527