Deneysel Olarak Diabet Oluşturulmuş Ratlarda Yara İyileşmesinde Sildenafil Sitratın Bazı Hematolojik Parametrelere ve Mineral Maddelere Etkisi

Bahat COMBA; Leyla MİS; Arzu COMBA; Ali ÇINAR; Abuzer TAŞ

Makale detayları

Deneysel Olarak Diabet Oluşturulmuş Ratlarda Yara İyileşmesinde Sildenafil Sitratın Bazı Hematolojik Parametrelere ve Mineral Maddelere Etkisi

Yazarlar:

Bahat COMBA | Leyla MİS | Arzu COMBA | Ali ÇINAR | Abuzer TAŞ

Yayıncı:

Ataturk University

Dergi:

Atatürk University Journal of Veterinary Sciences 2014 Vol.9 Issue 3

Belge Tipi:

Makale

Yayın Tarihi:

12/2014

Belge Dili:

Türkçe

Document ID (Org No.):

2000686780

Sıklık:

Aylık

eISSN:

2822-3608

Özet:

 

In this study, the effect of sildenafil citrate on some haematological parameters and mineral levels in the early stages of wound healing was investigated.Rats were randomly allocated into three treatment groups consisted of 10 rats in each. Groups were designed as control (group I), diabetic (group II) and diabetic plus sildenafil citrate (group III), respectively. Normal wound care was performed for control and group II. Sildenafil citrate was also administered with normal wound care for group III at 0.7 mg/kg dosage for 3 days via intraperitoneally (i.p.) once a day. Blood samples were collected before and at 1., 2., and., 3. days of after administration. Full blood erythrocyte (RBC), haemoglobin (HG), haematocrit (HCT) values were determined using standard methods; spectrophotometric methods were used for determination of the serum iron (Fe), manganese (Mn), copper (Cu), zinc (Zn), lead (Pb), potassium (K), calcium (Ca), and magnesium (Mg) levels. Sildenafil citrate increased the serum mineral levels (i.e. Zn, Cu and Mg), as having favourable impact on diabetic wound healing process. Likewise, it decreased the level of iron mineral, as having an adverse effect on the healing process. In conclusion, it was concluded that sildenafil citrate had a favourable effect on the healing process by shortening the inflammatory period, which is the first period of wound healing process.

Makale detayları

Deneysel Olarak Diabet Oluşturulmuş Ratlarda Yara İyileşmesinde Sildenafil Sitratın Bazı Hematolojik Parametrelere ve Mineral Maddelere Etkisi

Yazarlar: Bahat COMBA | Leyla MİS | Arzu COMBA | Ali ÇINAR | Abuzer TAŞ

Yayıncı: Ataturk University

Dergi: Atatürk University Journal of Veterinary Sciences 2014 Vol.9 Issue 3

Belge Tipi: Makale

Yayın Tarihi: 12/2014

Belge Dili: Türkçe

Document ID (Org No.): 2000686780

Sıklık: Aylık

eISSN: 2822-3608

Sayı

Yazarlar:

Bahat COMBA | Leyla MİS | Arzu COMBA | Ali ÇINAR | Abuzer TAŞ

Yayıncı:

Ataturk University

Dergi:

Atatürk University Journal of Veterinary Sciences 2014 Vol.9 Issue 3

Belge Tipi:

Makale

Yayın Tarihi:

12/2014

Belge Dili:

Türkçe

Document ID (Org No.):

2000686780

Sıklık:

Aylık

eISSN:

2822-3608