A Spectrophotometric Method for the Determination of Prazosin Hydrochloride in Tablets

Mahmure Üstün Özgür And Sıdıka SUNGUR

Makale detayları

A Spectrophotometric Method for the Determination of Prazosin Hydrochloride in Tablets

Yazarlar:

Mahmure Üstün Özgür And Sıdıka SUNGUR

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2002 Vol.26 Issue 5, pp.691-696

Belge Tipi:

Makale

Yayın Tarihi:

4/2002

Belge Dili:

Türkçe

Document ID (Org No.):

2000729770

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

Özet:

 

A rapid and sensitive analytical method was developed for the  spectrophotometric assay of prazosin hydrochloride.  The method is  based on the formation of a coloured derivative between the drug and  1,2-naphthoquinone-4- sulphonic acid sodium salt (NQS).  The reaction  proceeds quantitatively at pH 4.5 and 70°C for 40 min.   After the extraction of the derivative with chloroform: n-butanol  (3:1), the absorbance was measured at 400 nm.  The method was applied  to commercially available tablets and the results were statistically  compared with those obtained by ultraviolet spectrophotometric and  differential pulse polarographic methods using t- and F-tests.

 

A rapid and sensitive analytical method was developed for the  spectrophotometric assay of prazosin hydrochloride.  The method is  based on the formation of a coloured derivative between the drug and  1,2-naphthoquinone-4- sulphonic acid sodium salt (NQS).  The reaction  proceeds quantitatively at pH 4.5 and 70°C for 40 min.   After the extraction of the derivative with chloroform: n-butanol  (3:1), the absorbance was measured at 400 nm.  The method was applied  to commercially available tablets and the results were statistically  compared with those obtained by ultraviolet spectrophotometric and  differential pulse polarographic methods using t- and F-tests.

Makale detayları

A Spectrophotometric Method for the Determination of Prazosin Hydrochloride in Tablets

Yazarlar: Mahmure Üstün Özgür And Sıdıka SUNGUR

Yayıncı: TUBITAK

Dergi: Turkish Journal of Chemistry 2002 Vol.26 Issue 5, pp.691-696

Belge Tipi: Makale

Yayın Tarihi: 4/2002

Belge Dili: Türkçe

Document ID (Org No.): 2000729770

Sıklık: İki Aylık

eISSN: 1303-6130

pISSN: 1300-0527

Sayı

Yazarlar:

Mahmure Üstün Özgür And Sıdıka SUNGUR

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2002 Vol.26 Issue 5, pp.691-696

Belge Tipi:

Makale

Yayın Tarihi:

4/2002

Belge Dili:

Türkçe

Document ID (Org No.):

2000729770

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527