QF-PCR in invasive prenatal diagnosis: a single-center experience in Turkey

Özge Özer KAYA; Altuğ KOÇ; Taha Reşid ÖZDEMİR; Özgür KIRBIYIK; Berk ÖZYILMAZ; Mehmet ÖZEREN; Deniz Can ÖZTEKİN; Cüneyt Eftal TANER; Yaşar Bekir KUTBAY

Makale detayları

QF-PCR in invasive prenatal diagnosis: a single-center experience in Turkey

Yazarlar:

Özge Özer KAYA | Altuğ KOÇ | Taha Reşid ÖZDEMİR | Özgür KIRBIYIK | Berk ÖZYILMAZ | Mehmet ÖZEREN | Deniz Can ÖZTEKİN | Cüneyt Eftal TANER | Yaşar Bekir KUTBAY

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2017 Vol.47 Issue 1, pp.142-147

Belge Tipi:

Makale

Yayın Tarihi:

1/2017

Belge Dili:

Türkçe

Document ID (Org No.):

2000751561

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Özet:

 

Background/aim: QF-PCR has been used for more than 20 years. It is based on investigation of polymorphic short tandem repeats (STRs) and is widely used for prenatal rapid aneuploidy detection.  Materials and methods: We report retrospectively our prenatal diagnosis results between January 2012 and May 2014 in Tepecik Training and Research Hospital Genetic Diagnostic Center. Prenatal diagnosis was recommended in 6800 high-risk pregnancies and 2883 patients agreed to invasive diagnosis. Chromosome analysis and QF-PCR were performed in all patients.   Results: Normal results were reported in 2711 cases by fetal karyotyping and in 2706 cases by QF-PCR. Anomaly detection rates were similar for the two methods (5.09% for karyotyping and 4.02% for QF-PCR).   Conclusion: QF-PCR is a fast and reliable prenatal diagnosis method in all indication groups and may be preferred as the sole prenatal investigation in patients without fetal ultrasonographic findings.

Makale detayları

QF-PCR in invasive prenatal diagnosis: a single-center experience in Turkey

Yazarlar: Özge Özer KAYA | Altuğ KOÇ | Taha Reşid ÖZDEMİR | Özgür KIRBIYIK | Berk ÖZYILMAZ | Mehmet ÖZEREN | Deniz Can ÖZTEKİN | Cüneyt Eftal TANER | Yaşar Bekir KUTBAY

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2017 Vol.47 Issue 1, pp.142-147

Belge Tipi: Makale

Yayın Tarihi: 1/2017

Belge Dili: Türkçe

Document ID (Org No.): 2000751561

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Sayı

Yazarlar:

Özge Özer KAYA | Altuğ KOÇ | Taha Reşid ÖZDEMİR | Özgür KIRBIYIK | Berk ÖZYILMAZ | Mehmet ÖZEREN | Deniz Can ÖZTEKİN | Cüneyt Eftal TANER | Yaşar Bekir KUTBAY

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2017 Vol.47 Issue 1, pp.142-147

Belge Tipi:

Makale

Yayın Tarihi:

1/2017

Belge Dili:

Türkçe

Document ID (Org No.):

2000751561

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144