DIODE ARRAY DETECTOR ELECTROSPRAY MASS  SPECTROMETRY LIQUID CHROMATOGRAPHY AS APPLIED TO  PARTIALLY OVERLAPPING PEAKS

Richard G BRERETON

Makale detayları

DIODE ARRAY DETECTOR ELECTROSPRAY MASS SPECTROMETRY LIQUID CHROMATOGRAPHY AS APPLIED TO PARTIALLY OVERLAPPING PEAKS

Yazarlar:

Richard G BRERETON

Yayıncı:

Balıkesir University

Dergi:

Journal of Balıkesir University Institute of Science and Technology 2000 Vol.2 Issue 2, pp.34-34

Belge Tipi:

Makale

Yayın Tarihi:

5/2000

Belge Dili:

Türkçe

Document ID (Org No.):

2000926159

Sıklık:

İki Yıllık

eISSN:

2536-5142

pISSN:

1301-7985

Özet:

 

It is now common to obtain information from two or more detectors
in HPLC simultaneously. Conventionally both DAD-HPLC and LC-MS data
are obtained independently, often using quite different approaches, but there
will be common features in both types of information. However, these will
be distorted, for example, Electrospray MS profiles are typically more noisy
and tailing compared to those from DAD-HPLC due to the different physical
processes of passing from the chromatographic column to the detector. A
method for obtaining and processing both types of data simultaneously is
described. The analysis of isomers with identical molecular weights and
similar elution times is particularly important in the pharmaceutical industry
where small impurities can have a major influence on biological activity.
The approach is illustrated by application to a mixture of 2- and 3-
hydroxypyridine at varying levels of overlap.

Makale detayları

DIODE ARRAY DETECTOR ELECTROSPRAY MASS SPECTROMETRY LIQUID CHROMATOGRAPHY AS APPLIED TO PARTIALLY OVERLAPPING PEAKS

Yazarlar: Richard G BRERETON

Yayıncı: Balıkesir University

Dergi: Journal of Balıkesir University Institute of Science and Technology 2000 Vol.2 Issue 2, pp.34-34

Belge Tipi: Makale

Yayın Tarihi: 5/2000

Belge Dili: Türkçe

Document ID (Org No.): 2000926159

Sıklık: İki Yıllık

eISSN: 2536-5142

pISSN: 1301-7985

Sayı

Yazarlar:

Richard G BRERETON

Yayıncı:

Balıkesir University

Dergi:

Journal of Balıkesir University Institute of Science and Technology 2000 Vol.2 Issue 2, pp.34-34

Belge Tipi:

Makale

Yayın Tarihi:

5/2000

Belge Dili:

Türkçe

Document ID (Org No.):

2000926159

Sıklık:

İki Yıllık

eISSN:

2536-5142

pISSN:

1301-7985