Evaluation of MIF -173 G/C Polymorphism in Turkish Patients with Ankylosing Spondylitis

Çevik GÜREL; Ahmet İNANIR; Ayşe Feyda NURSAL; Akın TEKCAN; Aydın RÜSTEMOĞLU; Serbülent YİĞİT

Makale detayları

Evaluation of MIF -173 G/C Polymorphism in Turkish Patients with Ankylosing Spondylitis

Yazarlar:

Çevik GÜREL | Ahmet İNANIR | Ayşe Feyda NURSAL | Akın TEKCAN | Aydın RÜSTEMOĞLU | Serbülent YİĞİT

Yayıncı:

Trakya University

Dergi:

Balkan Medical Journal 2016 Vol.33 Issue 6, pp.614-619

Belge Tipi:

Makale

Yayın Tarihi:

10/2016

Belge Dili:

Türkçe

Document ID (Org No.):

2000759339

Sıklık:

İki Aylık

pISSN:

2146-3123

Özet:

 

Background: Ankylosing spondylitis (AS) is a chronic inflammatory disease mainly affecting the spine and sacroiliac joints. Macrophage migration inhibitory (MIF) factor is a regulatory cytokine that inhibits random immune cell migration. MIF gene promoter polymorphisms play a role in the progression of several inflammatory disorders.     Aims: To investigate the relationship between the MIF gene -173 G/C single-nucleotide polymorphism (SNP) and AS.     Study Design: Cross-sectional study.     Methods: In this study, a total of 161 AS and 194 normal controls were recruited. The MIF gene -173 G/C SNP was analyzed by polymerase chain reaction using the restriction fragment length polymorphism method.      Results: There was no significant difference between groups in terms of genotype distribution (p>0.05). When wild-type G/G and G/C+C/C genotypes are compared in terms of clinical characteristics, there is a significant difference between the average age and the duration of disease in AS patients (p<0.05).      Conclusion: No significant relationship between AS disease and MIF -173 G/C polymorphism was found. MIF -173 G/C polymorphism (C allele) may affect the time of onset and the duration of disease in AS patients.

Makale detayları

Evaluation of MIF -173 G/C Polymorphism in Turkish Patients with Ankylosing Spondylitis

Yazarlar: Çevik GÜREL | Ahmet İNANIR | Ayşe Feyda NURSAL | Akın TEKCAN | Aydın RÜSTEMOĞLU | Serbülent YİĞİT

Yayıncı: Trakya University

Dergi: Balkan Medical Journal 2016 Vol.33 Issue 6, pp.614-619

Belge Tipi: Makale

Yayın Tarihi: 10/2016

Belge Dili: Türkçe

Document ID (Org No.): 2000759339

Sıklık: İki Aylık

pISSN: 2146-3123

Sayı

Yazarlar:

Çevik GÜREL | Ahmet İNANIR | Ayşe Feyda NURSAL | Akın TEKCAN | Aydın RÜSTEMOĞLU | Serbülent YİĞİT

Yayıncı:

Trakya University

Dergi:

Balkan Medical Journal 2016 Vol.33 Issue 6, pp.614-619

Belge Tipi:

Makale

Yayın Tarihi:

10/2016

Belge Dili:

Türkçe

Document ID (Org No.):

2000759339

Sıklık:

İki Aylık

pISSN:

2146-3123