Evaluation and epigenetic impact of B12, vitamin D, folic acid and anemia in Hashimoto's thyroiditis: a clinical and molecular docking study

Elif Sibel Aslan; Savaş Gür

Makale detayları

Evaluation and epigenetic impact of B12, vitamin D, folic acid and anemia in Hashimoto's thyroiditis: a clinical and molecular docking study

Yazarlar:

Elif Sibel Aslan | Savaş Gür

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Endokrinoloji | Sağlık Kurumları Yönetimi

Dergi:

Journal of Health Sciences and Medicine Vol.6 Issue 4, pp.705-712

Belge Tipi:

Makale

Yayın Tarihi:

7/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001293505

pISSN:

2636-8579

Anahtar kelimeler:

Özet:

 Aims: Our approach in this study is to investigate the collective effect of various parameters, including vitamin B12 B12, vitamin D Vit-D, folic acid, and iron deficiency, on Hashimotos thyroiditis HT disease. This differs from existing literature that has examined these parameters individually. Methods: The study evaluated age, gender, thyroid stimulating hormone TSH, free-T4 FT4, free-T3 FT3, Vit-D levels, as well as autoantibodies against thyroid peroxidase anti-TPO and anti-tyroglobulin iron anti-TG levels, ferritin, B12, and folic acid parameters in a total of 30 HT patients and 37 non-HT patients. These parameters were assessed by analyzing the patients routine blood test results using automated analysis methods. Results: A negative correlation was found between the blood, Vit-D level and anti-TG as the vit-D value increases, the anti-TG decreases r-0.417; p0.001; p0.01. There was a statistically significant and weak correlation between blood Vit-D measurements and anti-TPO measurements r-0.341; p0.005; p0.01. Conclusion: The study findings demonstrated that there was no statistically significant difference in the measurements and correlation between hemoglobin, FT3, FT4, TSH, ferritin, vitamin B12, and folic acid levels in patients with and without a diagnosis of HT p0.05. However, the study emphasized the critical role of vitamin D in the pathophysiology and treatment of HT. Furthermore, molecular docking simulations indicated that folic acid could potentially act as a potent inhibitor of human extracellular signal-regulated kinase ERK2, which has been reported to play a key role in HT.

 Aims: Our approach in this study is to investigate the collective effect of various parameters, including vitamin B12 B12, vitamin D Vit-D, folic acid, and iron deficiency, on Hashimotos thyroiditis HT disease. This differs from existing literature that has examined these parameters individually. Methods: The study evaluated age, gender, thyroid stimulating hormone TSH, free-T4 FT4, free-T3 FT3, Vit-D levels, as well as autoantibodies against thyroid peroxidase anti-TPO and anti-tyroglobulin iron anti-TG levels, ferritin, B12, and folic acid parameters in a total of 30 HT patients and 37 non-HT patients. These parameters were assessed by analyzing the patients routine blood test results using automated analysis methods. Results: A negative correlation was found between the blood, Vit-D level and anti-TG as the vit-D value increases, the anti-TG decreases r-0.417; p0.001; p0.01. There was a statistically significant and weak correlation between blood Vit-D measurements and anti-TPO measurements r-0.341; p0.005; p0.01. Conclusion: The study findings demonstrated that there was no statistically significant difference in the measurements and correlation between hemoglobin, FT3, FT4, TSH, ferritin, vitamin B12, and folic acid levels in patients with and without a diagnosis of HT p0.05. However, the study emphasized the critical role of vitamin D in the pathophysiology and treatment of HT. Furthermore, molecular docking simulations indicated that folic acid could potentially act as a potent inhibitor of human extracellular signal-regulated kinase ERK2, which has been reported to play a key role in HT.

 Aims: Our approach in this study is to investigate the collective effect of various parameters, including vitamin B12 B12, vitamin D Vit-D, folic acid, and iron deficiency, on Hashimotos thyroiditis HT disease. This differs from existing literature that has examined these parameters individually. Methods: The study evaluated age, gender, thyroid stimulating hormone TSH, free-T4 FT4, free-T3 FT3, Vit-D levels, as well as autoantibodies against thyroid peroxidase anti-TPO and anti-tyroglobulin iron anti-TG levels, ferritin, B12, and folic acid parameters in a total of 30 HT patients and 37 non-HT patients. These parameters were assessed by analyzing the patients routine blood test results using automated analysis methods. Results: A negative correlation was found between the blood, Vit-D level and anti-TG as the vit-D value increases, the anti-TG decreases r-0.417; p0.001; p0.01. There was a statistically significant and weak correlation between blood Vit-D measurements and anti-TPO measurements r-0.341; p0.005; p0.01. Conclusion: The study findings demonstrated that there was no statistically significant difference in the measurements and correlation between hemoglobin, FT3, FT4, TSH, ferritin, vitamin B12, and folic acid levels in patients with and without a diagnosis of HT p0.05. However, the study emphasized the critical role of vitamin D in the pathophysiology and treatment of HT. Furthermore, molecular docking simulations indicated that folic acid could potentially act as a potent inhibitor of human extracellular signal-regulated kinase ERK2, which has been reported to play a key role in HT.

 Aim:This study aimed to evaluate the frequency of B12, vitamin D, folic acid and iron deficiency, which play a role in the pathogenesis and epigenetic effect on HT, compared to individuals without thyroid disease. Materials and Methods:Age, gender, thyroid stimulating hormone TSH, free-T4 FT4, free-T3 FT3, vit-D among 30 HT patients and 37 non-HT patients admitted to the outpatient clinic between January and December 2021, anti-TPO and Anti-Tyroglobulin iron, vit-D, ferritin, B12, folic acid parameters were evaluated by checking the patients routine blood test results taken by autoanalysis between groups. Results:When the vit-D levels of 30 patients with HT and 37 patients without a diagnosis of HT were compared, a difference was found between vit-D levels. A negative correlation was found between the blood, vit-D level and Anti-TG as the vit-D value increases, the Anti-Tyroglobulin value decreases r-0.417; p0.001; p0.01. There was a statistically significant and weak correlation between blood vit-D measurements and Anti-TPO measurements r-0.341; p0.005; p0.01. Conclusion:When evaluated in terms of Hemoglobin, FT3, FT4, TSH, Ferritin, Vitamin B12, and Folic acid between patients with and without a diagnosis of HT, their measurements did not show a statistically significant difference p0.05. Once again, the importance of vit-D deficiency in the physiopathology and treatment of HT, the elimination of vit-D deficiency have actually been shown how important in the treatment process of HT. On the other hand, molecular docking simulations revealed that folic acid might be a strong inhibitor of human extracellular signal-regulated kinase ERK2 which was reported to have a key role in HT.

Makale detayları

Evaluation and epigenetic impact of B12, vitamin D, folic acid and anemia in Hashimoto's thyroiditis: a clinical and molecular docking study

Yazarlar:

Elif Sibel Aslan | Savaş Gür

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Endokrinoloji | Sağlık Kurumları Yönetimi

Dergi:

Journal of Health Sciences and Medicine Vol.6 Issue 4, pp.705-712

Belge Tipi:

Makale

Yayın Tarihi:

7/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001293505

pISSN:

2636-8579

Hashimoto

otoimmun disease

vitamin D

anti-TPO

ferritin

vitamin B12Hashimoto

otoimmun disease

Vitamin D (vit-D)

anti-TPO

Ferritin

Vitamin B12

Sayı

Makale detayları

Yazarlar: Elif Sibel Aslan | Savaş Gür

Yayıncı: MediHealth Academy Yayıncılık

Ana Başlıklar: Endokrinoloji | Sağlık Kurumları Yönetimi

Dergi: Journal of Health Sciences and Medicine Vol.6 Issue 4, pp.705-712

Belge Tipi: Makale

Yayın Tarihi: 7/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001293505

pISSN: 2636-8579

Sayı

Yazarlar:

Elif Sibel Aslan | Savaş Gür

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Endokrinoloji | Sağlık Kurumları Yönetimi

Dergi:

Journal of Health Sciences and Medicine Vol.6 Issue 4, pp.705-712

Belge Tipi:

Makale

Yayın Tarihi:

7/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001293505

pISSN:

2636-8579