Clinical Characteristics of Interstitial pneumonia with autoimmune features: A Single-Center Experience

Nurdan Oruçoğlu; Yüksel Balcı

Makale detayları

Clinical Characteristics of Interstitial pneumonia with autoimmune features: A Single-Center Experience

Yazarlar:

Nurdan Oruçoğlu | Yüksel Balcı

Yayıncı:

Manisa Celal Bayar University

Ana Başlıklar:

Radyoloji ve Organ Görüntüleme | Romatoloji ve Artrit

Dergi:

Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi Vol.10 Issue 4, pp.328-333

Belge Tipi:

Makale

Yayın Tarihi:

12/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001306098

pISSN:

2147-9607

Anahtar kelimeler:

Özet:

 Objective: Interstitial pneumonia with autoimmune features IPAF is a recently determined condition characterized by clinical or serological symptoms indicative of an underlying autoimmune process but without fulfilling connective tissue disease classification criteria. This study aims to identify the clinical, serological, and morphological features of AFIP patients. Materials and Methods: This is a retrospective cohort study. A total of 38 patients diagnosed with AFIP in the Rheumatology outpatient clinic of XXX University between 2015 and 2022 were included in the study. Results: The patients mean age was 58.26 12.31. The majority of patients n27, 71 female were female. The most frequently described clinical features among patients were inflammatory arthritis or polyarticular morning joint stiffness lasting more than 60 minutes n9, 23.6 and Raynauds phenomenon n9, 23.6. The most commonly identified serological findings were antinuclear antibody ANA n27, 71.1, Anti-RoSSA antibody n6, 15.8, rheumatoid factor n5, 13.2, and Anti-cyclic citrullinated peptide Anti-CCP n5, 13.2 positivity. The mean follow-up was 43.21  23.30 months, and only one out of 10 patients who died during the follow-up was associated with IPAF. Thirty-one 81.5 patients were treated with immunosuppressants, and 29 76.3 were given steroid treatment. The most commonly used immunosuppressive drug with steroids was cyclophosphamide n9, 23.6. Anti-fibrotic therapy was administered to 4 patients 10.5 who did not respond adequately to immunosuppressive drugs. Morphologically, the most frequent radiological pattern was the non-specific interstitial pneumonia NSIP pattern n12, 26.3. Conclusion: This single-center study demonstrated that IPAF primarily affects females, often presents with joint manifestations and Raynauds phenomenon, and more frequently exhibits the NSIP pattern on imaging. Due to the heterogeneity of IPAF, defining its clinical and morphological characteristics is essential for early diagnosis and treatment.

 Objective: Interstitial pneumonia with autoimmune features IPAF is a recently determined condition characterized by clinical or serological symptoms indicative of an underlying autoimmune process but without fulfilling connective tissue disease classification criteria. This study aims to identify the clinical, serological, and morphological features of AFIP patients. Materials and Methods: This is a retrospective cohort study. A total of 38 patients diagnosed with AFIP in the Rheumatology outpatient clinic of XXX University between 2015 and 2022 were included in the study. Results: The patients mean age was 58.26 12.31. The majority of patients n27, 71 female were female. The most frequently described clinical features among patients were inflammatory arthritis or polyarticular morning joint stiffness lasting more than 60 minutes n9, 23.6 and Raynauds phenomenon n9, 23.6. The most commonly identified serological findings were antinuclear antibody ANA n27, 71.1, Anti-RoSSA antibody n6, 15.8, rheumatoid factor n5, 13.2, and Anti-cyclic citrullinated peptide Anti-CCP n5, 13.2 positivity. The mean follow-up was 43.21  23.30 months, and only one out of 10 patients who died during the follow-up was associated with IPAF. Thirty-one 81.5 patients were treated with immunosuppressants, and 29 76.3 were given steroid treatment. The most commonly used immunosuppressive drug with steroids was cyclophosphamide n9, 23.6. Anti-fibrotic therapy was administered to 4 patients 10.5 who did not respond adequately to immunosuppressive drugs. Morphologically, the most frequent radiological pattern was the non-specific interstitial pneumonia NSIP pattern n12, 26.3. Conclusion: This single-center study demonstrated that IPAF primarily affects females, often presents with joint manifestations and Raynauds phenomenon, and more frequently exhibits the NSIP pattern on imaging. Due to the heterogeneity of IPAF, defining its clinical and morphological characteristics is essential for early diagnosis and treatment.

 Objective: Interstitial pneumonia with autoimmune features IPAF is a recently determined condition characterized by clinical or serological symptoms indicative of an underlying autoimmune process but without fulfilling connective tissue disease classification criteria. This study aims to identify the clinical, serological, and morphological features of AFIP patients. Materials and Methods: This is a retrospective cohort study. A total of 38 patients diagnosed with AFIP in the Rheumatology outpatient clinic of XXX University between 2015 and 2022 were included in the study. Results: The patients mean age was 58.26 12.31. The majority of patients n27, 71 female were female. The most frequently described clinical features among patients were inflammatory arthritis or polyarticular morning joint stiffness lasting more than 60 minutes n9, 23.6 and Raynauds phenomenon n9, 23.6. The most commonly identified serological findings were antinuclear antibody ANA n27, 71.1, Anti-RoSSA antibody n6, 15.8, rheumatoid factor n5, 13.2, and Anti-cyclic citrullinated peptide Anti-CCP n5, 13.2 positivity. The mean follow-up was 43.21  23.30 months, and only one out of 10 patients who died during the follow-up was associated with IPAF. Thirty-one 81.5 patients were treated with immunosuppressants, and 29 76.3 were given steroid treatment. The most commonly used immunosuppressive drug with steroids was cyclophosphamide n9, 23.6. Anti-fibrotic therapy was administered to 4 patients 10.5 who did not respond adequately to immunosuppressive drugs. Morphologically, the most frequent radiological pattern was the non-specific interstitial pneumonia NSIP pattern n12, 26.3. Conclusion: This single-center study demonstrated that IPAF primarily affects females, often presents with joint manifestations and Raynauds phenomenon, and more frequently exhibits the NSIP pattern on imaging. Due to the heterogeneity of IPAF, defining its clinical and morphological characteristics is essential for early diagnosis and treatment.

 Giriş ve Amaç: Otoimmün özellikli interstisyel pnömoni OÖİP, altta yatan otoimmün bir süreci düşündüren klinik veya serolojik özelliklerin mevcut olduğu; ancak bağ doku hastalıkları için tanımlanmış sınıflandırma kriterlerinin karşılanmadığı, yakın zamanda tanımlanmış bir antitedir. Bu çalışmanın amacı, OÖİP hastalarının klinik, serolojik ve morfolojik özelliklerini belirlemektir. Gereç ve Yöntemler: Bu çalışma bir retrospektif kohort çalışmasıdır. Çalışmaya 2015-2022 tarihleri arasında XXX üniversitesi Romatoloji bölümünde OÖİP tanısı ile takip edilen 38 hasta dahil edilmiştir. Bulgular: Çalışmadaki hastaların yaş ortalamaları 58,26  12,31 idi. Çoğunluğu n27, 71 kadın hastalar oluşturmaktaydı. Hastalarda en sık tanımlanan klinik özellikler inflamatuar artrit veya 60 dakikadan uzun süren poliartiküler sabah sertliği n9, 23,6 ve Raynaud fenomeniydi n9, 23,6. En sık tanımlanan serolojik bulgular antinükleer antikor ANA pozitifliği n27, 71,1, Anti-RoSSA antikor pozitifliği n6, 15,8, romatoid faktör RF n5, 13,2 ve Anti-Siklik sitrüline peptid pozitifliği Anti-CCP n5, 13,2 idi. Ortalama takip süresi 43,21  23,30 ay olup, takip süresince ex olan 10 hastadan yalnızca biri OÖIP ile ilişkilendirilmiştir. Hastaların 31i 81,5 immünsüpresiflerle tedavi edilmiş olup, 29una 76,3 steroid tedavisi verilmiştir. Steroidlerle birlikte en çok kullanılan immünsüpresif ilaç siklofosfamid n9, 23,6 idi. İmmünsupresif ilaçlara yeterli yanıt alınamayan 4 hastaya 10,5 ise anti-fibrotik verilmiştir. Morfolojik alanda radyolojik paternler içerisinde en sık nonspesifik interstisyel pnömoni NSİP paterni gözlenmiştir n 15, 39,5. Sonuç: Tek merkez deneyimini sunan bu çalışmada OÖİPnin çoğunlukla kadın hastalardan oluştuğu, sıklıkla eklem bulguları ve Raynaud ile prezente olduğu ve görüntülemede en sık NSİP paterni özelliklerini gösterdikleri belirlenmiştir. Oldukça heterojen özellikler gösteren OÖİPnin klinik ve morfolojik özelliklerinin iyi belirlenmesi, hastalığın erken tanısı ve tedavisi için önemlidir.

Makale detayları

Clinical Characteristics of Interstitial pneumonia with autoimmune features: A Single-Center Experience

Yazarlar:

Nurdan Oruçoğlu | Yüksel Balcı

Yayıncı:

Manisa Celal Bayar University

Ana Başlıklar:

Radyoloji ve Organ Görüntüleme | Romatoloji ve Artrit

Dergi:

Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi Vol.10 Issue 4, pp.328-333

Belge Tipi:

Makale

Yayın Tarihi:

12/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001306098

pISSN:

2147-9607

Rheumatic disease

interstitial lung disease

interstitial pneumonia with autoimmune features

idiopathic pulmonary fibrosisotoimmün özellikli interstisyel pnömoni

Romatolojik hastalık

interstisyel akciğer hastalığı

idiopatik pulmoner fibrozis

Sayı

Makale detayları

Yazarlar: Nurdan Oruçoğlu | Yüksel Balcı

Yayıncı: Manisa Celal Bayar University

Ana Başlıklar: Radyoloji ve Organ Görüntüleme | Romatoloji ve Artrit

Dergi: Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi Vol.10 Issue 4, pp.328-333

Belge Tipi: Makale

Yayın Tarihi: 12/2023

Belge Dili: Türkçe

Document ID (Org No.): 2001306098

pISSN: 2147-9607

Sayı

Yazarlar:

Nurdan Oruçoğlu | Yüksel Balcı

Yayıncı:

Manisa Celal Bayar University

Ana Başlıklar:

Radyoloji ve Organ Görüntüleme | Romatoloji ve Artrit

Dergi:

Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi Vol.10 Issue 4, pp.328-333

Belge Tipi:

Makale

Yayın Tarihi:

12/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001306098

pISSN:

2147-9607