Development and validation of Q-absorbance ratio spectrophotometric method for simultaneous estimation of ondansetron HCl and esomeprazole magnesium in bulk and formulation

N.A.

Makale detayları

Development and validation of Q-absorbance ratio spectrophotometric method for simultaneous estimation of ondansetron HCl and esomeprazole magnesium in bulk and formulation

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.27 Issue 6, pp.2522-2529

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346315

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 The current study describes a Q- Absorption Ratio spectrophotometric method development and validation for the simultaneous determination of esomeprazole magnesium and ondansetron hydrochloride. The concentration of the drugs was determined by using the ratio of absorbance at the iso-absorptive point λ1  275 nm and the λmax of esomeprazole magnesium λ2  302 nm. This method is linear for both drugs in the range of 525 μgmL at λ1 R2  0.999 and at λ2 R2  0.9998 for ondansetron hydrochloride, and esomeprazole magnesium found at λ1 R2  0.9995 and λ2 R2  0.9997. According to ICH recommendations Q2R1, statistical analysis and recovery studies have been used to validate the analysis findings. The  Recovery was 97.78  100.81  of ondansetron and 100.33  102.03  of esomeprazole by the standard addition method. The method was found to be precise as the  relative standard deviation was less than 2.00 in interday and intraday precision for ondansetron and esomeprazole. The results of the current study indicated that the developed method is simple, linear, precise, accurate, and sensitive, hence may be used for quality control purposes.

 The current study describes a Q- Absorption Ratio spectrophotometric method development and validation for the simultaneous determination of esomeprazole magnesium and ondansetron hydrochloride. The concentration of the drugs was determined by using the ratio of absorbance at the iso-absorptive point λ1  275 nm and the λmax of esomeprazole magnesium λ2  302 nm. This method is linear for both drugs in the range of 525 μgmL at λ1 R2  0.999 and at λ2 R2  0.9998 for ondansetron hydrochloride, and esomeprazole magnesium found at λ1 R2  0.9995 and λ2 R2  0.9997. According to ICH recommendations Q2R1, statistical analysis and recovery studies have been used to validate the analysis findings. The  Recovery was 97.78  100.81  of ondansetron and 100.33  102.03  of esomeprazole by the standard addition method. The method was found to be precise as the  relative standard deviation was less than 2.00 in interday and intraday precision for ondansetron and esomeprazole. The results of the current study indicated that the developed method is simple, linear, precise, accurate, and sensitive, hence may be used for quality control purposes.

 The current study describes a Q- Absorption Ratio spectrophotometric method development and validation for the simultaneous determination of esomeprazole magnesium and ondansetron hydrochloride. The concentration of the drugs was determined by using the ratio of absorbance at the iso-absorptive point λ1  275 nm and the λmax of esomeprazole magnesium λ2  302 nm. This method is linear for both drugs in the range of 525 μgmL at λ1 R2  0.999 and at λ2 R2  0.9998 for ondansetron hydrochloride, and esomeprazole magnesium found at λ1 R2  0.9995 and λ2 R2  0.9997. According to ICH recommendations Q2R1, statistical analysis and recovery studies have been used to validate the analysis findings. The  Recovery was 97.78  100.81  of ondansetron and 100.33  102.03  of esomeprazole by the standard addition method. The method was found to be precise as the  relative standard deviation was less than 2.00 in interday and intraday precision for ondansetron and esomeprazole. The results of the current study indicated that the developed method is simple, linear, precise, accurate, and sensitive, hence may be used for quality control purposes.

 The current study describes a Q- Absorption Ratio spectrophotometric method development and validation for the simultaneous determination of esomeprazole magnesium and ondansetron hydrochloride. The concentration of the drugs was determined by using the ratio of absorbance at the iso-absorptive point λ1  275 nm and the λmax of esomeprazole magnesium λ2  302 nm. This method is linear for both drugs in the range of 525 μgmL at λ1 R2  0.999 and at λ2 R2  0.9998 for ondansetron hydrochloride, and esomeprazole magnesium found at λ1 R2  0.9995 and λ2 R2  0.9997. According to ICH recommendations Q2R1, statistical analysis and recovery studies have been used to validate the analysis findings. The  Recovery was 97.78  100.81  of ondansetron and 100.33  102.03  of esomeprazole by the standard addition method. The method was found to be precise as the  relative standard deviation was less than 2.00 in interday and intraday precision for ondansetron and esomeprazole. The results of the current study indicated that the developed method is simple, linear, precise, accurate, and sensitive, hence may be used for quality control purposes.

Makale detayları

Development and validation of Q-absorbance ratio spectrophotometric method for simultaneous estimation of ondansetron HCl and esomeprazole magnesium in bulk and formulation

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.27 Issue 6, pp.2522-2529

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346315

pISSN:

2630-6344

Ondansetron hydrochloride

esomeprazole

UV-spectrophotometer

validation

accuracy

precision

Sayı

Makale detayları

Development and validation of Q-absorbance ratio spectrophotometric method for simultaneous estimation of ondansetron HCl and esomeprazole magnesium in bulk and formulation

Yazarlar: N.A.

Yayıncı: Marmara University

Ana Başlıklar: Pharmacology and Pharmaceutical Sciences (Other)

Dergi: Journal of Research in Pharmacy Vol.27 Issue 6, pp.2522-2529

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001346315

pISSN: 2630-6344

Ondansetron hydrochloride

esomeprazole

UV-spectrophotometer

validation

accuracy

precision

Sayı

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.27 Issue 6, pp.2522-2529

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346315

pISSN:

2630-6344