The role of neurotensin receptor 1 on fear memory in mice

Ruhan Deniz Topuz

Makale detayları

The role of neurotensin receptor 1 on fear memory in mice

Yazarlar:

Ruhan Deniz Topuz

Yayıncı:

Marmara University

Ana Başlıklar:

Medical Pharmacology

Dergi:

Journal of Research in Pharmacy Vol.25 Issue 5, pp.609-615

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346227

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 Neurotensin NT is commonly found in the central nervous system and the gastrointestinal tract and known to play role as a neurotransmitterneuromodulatorneurohormone. We aimed to investigate the effect of the neurotensin receptor agonist PD149163 and the neurotensin receptor antagonist SR142948 on contextual and cued fear conditioning. In total 174 male Balbc mice were divided into 29 groups. In the behavioral experiments, the NT receptor agonist PD149163 0.25, 1, 4 mgkg or NT receptor antagonist SR142948 0.1, 1, 3 mgkg were administered to subjects before conditioning on the first day acquisition phase or before the test performed 24 h after conditioning retrieval. Rota-rod test, contextual and cued fear conditioning test were performed in all groups. It was observed that the neurotensin receptor agonist PD149163 had no effect on learning in the cued fear conditioning test, but enhanced retrieval dose-dependently. The neurotensin receptor antagonist SR142948 did not affect the learning and retrieval processes in cued fear conditioning. In the contextual fear conditioning test, neither the neurotensin receptor agonist PD149163 nor the neurotensin receptor antagonist SR142948 had any effect on the learning or retrieval of fear conditioning. Our results show that neurotensin receptor agonist PD149163 increases amygdala dependent cued fear conditioning responses dose-dependently.

 Neurotensin NT is commonly found in the central nervous system and the gastrointestinal tract and known to play role as a neurotransmitterneuromodulatorneurohormone. We aimed to investigate the effect of the neurotensin receptor agonist PD149163 and the neurotensin receptor antagonist SR142948 on contextual and cued fear conditioning. In total 174 male Balbc mice were divided into 29 groups. In the behavioral experiments, the NT receptor agonist PD149163 0.25, 1, 4 mgkg or NT receptor antagonist SR142948 0.1, 1, 3 mgkg were administered to subjects before conditioning on the first day acquisition phase or before the test performed 24 h after conditioning retrieval. Rota-rod test, contextual and cued fear conditioning test were performed in all groups. It was observed that the neurotensin receptor agonist PD149163 had no effect on learning in the cued fear conditioning test, but enhanced retrieval dose-dependently. The neurotensin receptor antagonist SR142948 did not affect the learning and retrieval processes in cued fear conditioning. In the contextual fear conditioning test, neither the neurotensin receptor agonist PD149163 nor the neurotensin receptor antagonist SR142948 had any effect on the learning or retrieval of fear conditioning. Our results show that neurotensin receptor agonist PD149163 increases amygdala dependent cued fear conditioning responses dose-dependently.

 Neurotensin NT is commonly found in the central nervous system and the gastrointestinal tract and known to play role as a neurotransmitterneuromodulatorneurohormone. We aimed to investigate the effect of the neurotensin receptor agonist PD149163 and the neurotensin receptor antagonist SR142948 on contextual and cued fear conditioning. In total 174 male Balbc mice were divided into 29 groups. In the behavioral experiments, the NT receptor agonist PD149163 0.25, 1, 4 mgkg or NT receptor antagonist SR142948 0.1, 1, 3 mgkg were administered to subjects before conditioning on the first day acquisition phase or before the test performed 24 h after conditioning retrieval. Rota-rod test, contextual and cued fear conditioning test were performed in all groups. It was observed that the neurotensin receptor agonist PD149163 had no effect on learning in the cued fear conditioning test, but enhanced retrieval dose-dependently. The neurotensin receptor antagonist SR142948 did not affect the learning and retrieval processes in cued fear conditioning. In the contextual fear conditioning test, neither the neurotensin receptor agonist PD149163 nor the neurotensin receptor antagonist SR142948 had any effect on the learning or retrieval of fear conditioning. Our results show that neurotensin receptor agonist PD149163 increases amygdala dependent cued fear conditioning responses dose-dependently.

 Neurotensin NT is commonly found in the central nervous system and the gastrointestinal tract and known to play role as a neurotransmitterneuromodulatorneurohormone. We aimed to investigate the effect of the neurotensin receptor agonist PD149163 and the neurotensin receptor antagonist SR142948 on contextual and cued fear conditioning. In total 174 male Balbc mice were divided into 29 groups. In the behavioral experiments, the NT receptor agonist PD149163 0.25, 1, 4 mgkg or NT receptor antagonist SR142948 0.1, 1, 3 mgkg were administered to subjects before conditioning on the first day acquisition phase or before the test performed 24 h after conditioning retrieval. Rota-rod test, contextual and cued fear conditioning test were performed in all groups. It was observed that the neurotensin receptor agonist PD149163 had no effect on learning in the cued fear conditioning test, but enhanced retrieval dose-dependently. The neurotensin receptor antagonist SR142948 did not affect the learning and retrieval processes in cued fear conditioning. In the contextual fear conditioning test, neither the neurotensin receptor agonist PD149163 nor the neurotensin receptor antagonist SR142948 had any effect on the learning or retrieval of fear conditioning. Our results show that neurotensin receptor agonist PD149163 increases amygdala dependent cued fear conditioning responses dose-dependently.

Makale detayları

The role of neurotensin receptor 1 on fear memory in mice

Yazarlar:

Ruhan Deniz Topuz

Yayıncı:

Marmara University

Ana Başlıklar:

Medical Pharmacology

Dergi:

Journal of Research in Pharmacy Vol.25 Issue 5, pp.609-615

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346227

pISSN:

2630-6344

Neurotensin

hippocampus

amygdala

fear conditioning

fear memory

Sayı

Makale detayları

The role of neurotensin receptor 1 on fear memory in mice

Yazarlar: Ruhan Deniz Topuz

Yayıncı: Marmara University

Ana Başlıklar: Medical Pharmacology

Dergi: Journal of Research in Pharmacy Vol.25 Issue 5, pp.609-615

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001346227

pISSN: 2630-6344

Neurotensin

hippocampus

amygdala

fear conditioning

fear memory

Sayı

Yazarlar:

Ruhan Deniz Topuz

Yayıncı:

Marmara University

Ana Başlıklar:

Medical Pharmacology

Dergi:

Journal of Research in Pharmacy Vol.25 Issue 5, pp.609-615

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346227

pISSN:

2630-6344