Short-Term Rectal Enema Probiotic Treatment with Intestinal Microbiota Analysis in Cats with Chronic Enteropathy

Kerem Ural; Hasan Erdoğan; Songül Erdoğan; Serdar Paşa; Tuğba Aslan; Cansu Balıkçı; Gamze Gökçay

Makale detayları

Short-Term Rectal Enema Probiotic Treatment with Intestinal Microbiota Analysis in Cats with Chronic Enteropathy

Yazarlar:

Kerem Ural | Hasan Erdoğan | Songül Erdoğan | Serdar Paşa | Tuğba Aslan | Cansu Balıkçı | Gamze Gökçay

Yayıncı:

Afyon Kocatepe University

Ana Başlıklar:

Veteriner Cerrahi

Dergi:

Kocatepe Veteriner Dergisi Vol.16 Issue 1, pp.16-30

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001282458

pISSN:

1308-1594

Anahtar kelimeler:

Özet:

 An imbalance in gut microbiota detected to serve as a predisposing factor for existence of chronic inflammation of the gastrointestinal tract, such as chronic enteropathy among cats. Given the postulation that probiotic administration might mitigate gastrointestinal disorders, its effects via rectal route have never been explored in our country among cats with chronic enteropathy. Thus the purpose of the present study was to evaluate the therapeutical efficacy of an multiple chain probiotic treatment involving Bifidobacterium combination Bifidobacterium longum, Bifidobacterium bifidum, Bifidobacterium animalis, Lactobacillus strains Lactobacillus rhamnosus, Lactobacillus gastricus, Lactobacillus acidophilus, Lactobacillus plantarum, Bacillus strains Bacillus clausii, Bacillus subtilis and a next generation probiotic Akkermansia muciniphilia via rectal route enemain cats with cEnT. Diagnosis was based on a clinical, b hematological and serum biochemical analysis along with scoring to those of Feline Chronic Enteropathy Activity Index FCEAI. Each cat was inspected and analyzedreevaluated and assigned a FCEAI score at the start and end of treatment for 10 day induction period. Rectal enema probiotic treatment resulted with significantly decreased composite FCEAI score p0.01 and laboratory parameters re-evaluation values p0.01 subjected to interpretation. This treatment modality without any side effects, should be subtitute other relevant treatment modalities with relapsing and degenerative effects.

 An imbalance in gut microbiota detected to serve as a predisposing factor for existence of chronic inflammation of the gastrointestinal tract, such as chronic enteropathy among cats. Given the postulation that probiotic administration might mitigate gastrointestinal disorders, its effects via rectal route have never been explored in our country among cats with chronic enteropathy. Thus the purpose of the present study was to evaluate the therapeutical efficacy of an multiple chain probiotic treatment involving Bifidobacterium combination Bifidobacterium longum, Bifidobacterium bifidum, Bifidobacterium animalis, Lactobacillus strains Lactobacillus rhamnosus, Lactobacillus gastricus, Lactobacillus acidophilus, Lactobacillus plantarum, Bacillus strains Bacillus clausii, Bacillus subtilis and a next generation probiotic Akkermansia muciniphilia via rectal route enemain cats with cEnT. Diagnosis was based on a clinical, b hematological and serum biochemical analysis along with scoring to those of Feline Chronic Enteropathy Activity Index FCEAI. Each cat was inspected and analyzedreevaluated and assigned a FCEAI score at the start and end of treatment for 10 day induction period. Rectal enema probiotic treatment resulted with significantly decreased composite FCEAI score p0.01 and laboratory parameters re-evaluation values p0.01 subjected to interpretation. This treatment modality without any side effects, should be subtitute other relevant treatment modalities with relapsing and degenerative effects.

 An imbalance in gut microbiota detected to serve as a predisposing factor for existence of chronic inflammation of the gastrointestinal tract, such as chronic enteropathy among cats. Given the postulation that probiotic administration might mitigate gastrointestinal disorders, its effects via rectal route have never been explored in our country among cats with chronic enteropathy. Thus the purpose of the present study was to evaluate the therapeutical efficacy of an multiple chain probiotic treatment involving Bifidobacterium combination Bifidobacterium longum, Bifidobacterium bifidum, Bifidobacterium animalis, Lactobacillus strains Lactobacillus rhamnosus, Lactobacillus gastricus, Lactobacillus acidophilus, Lactobacillus plantarum, Bacillus strains Bacillus clausii, Bacillus subtilis and a next generation probiotic Akkermansia muciniphilia via rectal route enemain cats with cEnT. Diagnosis was based on a clinical, b hematological and serum biochemical analysis along with scoring to those of Feline Chronic Enteropathy Activity Index FCEAI. Each cat was inspected and analyzedreevaluated and assigned a FCEAI score at the start and end of treatment for 10 day induction period. Rectal enema probiotic treatment resulted with significantly decreased composite FCEAI score p0.01 and laboratory parameters re-evaluation values p0.01 subjected to interpretation. This treatment modality without any side effects, should be subtitute other relevant treatment modalities with relapsing and degenerative effects.

 Bağırsak mikrobiyotasındaki bir dengesizlik, kedilerdeki kronik enteropatide olduğu gibi gastrointestinal sistemdeki kronik inflamasyon oluşumu için hazırlayıcı bir faktör olarak hizmet ettiği tespit edilmiştir. Probiyotik uygulamasının gastrointestinal rahatsızlıkları azaltabileceği varsayımı göz önüne alındığında, ülkemizde kronik enteropatili kedilerde rektal yoldan etkileri hiç araştırılmamıştır. Bu nedenle bu çalışmanın amacı, kedilerde Bifidobacterium kombinasyonu Bifidobacterium longum, Bifidobacterium bifidum, Bifidobacterium animalis, Lactobacillus suşları Lactobacillus rhamnosus, Lactobacillus gastrikus, Lactobacillus acidophilus, Bacillus suşları Bacillus clausii, Bacillus subtilis ve yeni nesil bir probiyotik Akkermansia muciniphiliayı içeren çok zincirli bir probiyotik tedavisinin terapötik etkinliğini kedilerde rektal yoldan enema değerlendirmektir. Teşhis, a klinik, b hematolojik ve serum biyokimyasal analizlerinin yanı sıra Feline Kronik Enteropati Aktivite İndeksine FCEAI göre puanlamaya dayanıyordu. Her kedi muayene edildi ve analiz edildiyeniden değerlendirildi ve 10 günlük indüksiyon dönemi için tedavinin başlangıcında ve sonunda bir FCEAI puanı verildi. Rektal lavman probiyotik tedavisi, yorumlamaya tabi tutulmuş kompozit FCEAI skoru p0.01 ve laboratuvar parametreleri yeniden değerlendirme değerleri p0.01 anlamlı derecede azalmıştır. Herhangi bir yan etkisi olmayan bu tedavi yöntemi, tekrarlayan ve dejeneratif etkileri olan diğer ilgili tedavi yöntemlerinin yerini almalıdır.

Makale detayları

Short-Term Rectal Enema Probiotic Treatment with Intestinal Microbiota Analysis in Cats with Chronic Enteropathy

Yazarlar:

Kerem Ural | Hasan Erdoğan | Songül Erdoğan | Serdar Paşa | Tuğba Aslan | Cansu Balıkçı | Gamze Gökçay

Yayıncı:

Afyon Kocatepe University

Ana Başlıklar:

Veteriner Cerrahi

Dergi:

Kocatepe Veteriner Dergisi Vol.16 Issue 1, pp.16-30

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001282458

pISSN:

1308-1594

dysbiosis

GI inflammation

Microbiome analysis

Probiotheraphy

disbiyoz

; Gİ inflamasyon

mikrobiyom analizi

probiyoterapi

Sayı

Makale detayları

Yazarlar: Kerem Ural | Hasan Erdoğan | Songül Erdoğan | Serdar Paşa | Tuğba Aslan | Cansu Balıkçı | Gamze Gökçay

Yayıncı: Afyon Kocatepe University

Ana Başlıklar: Veteriner Cerrahi

Dergi: Kocatepe Veteriner Dergisi Vol.16 Issue 1, pp.16-30

Belge Tipi: Makale

Yayın Tarihi: 3/2023

Belge Dili: Türkçe

Document ID (Org No.): 2001282458

pISSN: 1308-1594

Sayı

Yazarlar:

Kerem Ural | Hasan Erdoğan | Songül Erdoğan | Serdar Paşa | Tuğba Aslan | Cansu Balıkçı | Gamze Gökçay

Yayıncı:

Afyon Kocatepe University

Ana Başlıklar:

Veteriner Cerrahi

Dergi:

Kocatepe Veteriner Dergisi Vol.16 Issue 1, pp.16-30

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

Türkçe

Document ID (Org No.):

2001282458

pISSN:

1308-1594