Prevalence of cagA and babA2 positive Helicobacter pylori strains in dyspeptic patients in Iran

Mahsa ESMAEİLLU

doi:https://doi.org/10.5455/jicm.5.20160514

Makale detayları

Prevalence of cagA and babA2 positive Helicobacter pylori strains in dyspeptic patients in Iran

Yazarlar:

Mahsa ESMAEİLLU

Yayıncı:

Erkan YULA

Ana Başlıklar:

Hastalıklar

Dergi:

Journal of Immunology and Clinical Microbiology 2016 Vol.1 Issue 1, pp.10-13

Belge Tipi:

Makale

Yayın Tarihi:

5/2016

Belge Dili:

İngilizce

Document ID (Org No.):

2000741013

Sıklık:

Üç Aylık

eISSN:

2528-9470

DOI:

https://doi.org/10.5455/jicm.5.20160514

Özet:

 


Background: Helicobacter pylori genome encodes a
large number of virulence and adhesion factors that involved in bacterial
adhesion to host cells and exerts its virulence effect with CagA
secretion.  In this study, we aimed to
examine the relationships between babA2
and cagA genotype and presence of
gastric disorders in patients from Iran.


Material and Methods: The presence of H.
pylori and selected genes (cagA and
babA2) were detected by PCR method
from the genomic DNA of 105 patients who had been diagnosed with gastric
disorders like chronic gastritis by endoscopic and histopathologic routes.


Results:
Presence of H. pylori (glmM gene) was detected in 85 out of 105
(80.9%) patients. According to our results cagA
gene was found in 66 out of 85 (77.6%) patients and babA2 gene was found in 80 out of 85 (94.1%) patient. 


Conclusion: In
conclusion, the cagA and babA2 genotypes might be considered as
useful biomarkers for non-ulcer disease (NUD) patients and gastric disorders in
the geographic region of Iran and the presence of H. pylori strains with double-positive status is high clinical
relevance to H. pylori-associated
diseases.


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Makale detayları

Prevalence of cagA and babA2 positive Helicobacter pylori strains in dyspeptic patients in Iran

Yazarlar: Mahsa ESMAEİLLU

Yayıncı: Erkan YULA

Ana Başlıklar: Hastalıklar

Dergi: Journal of Immunology and Clinical Microbiology 2016 Vol.1 Issue 1, pp.10-13

Belge Tipi: Makale

Yayın Tarihi: 5/2016

Belge Dili: İngilizce

Document ID (Org No.): 2000741013

Sıklık: Üç Aylık

eISSN: 2528-9470

DOI: https://doi.org/10.5455/jicm.5.20160514

Sayı

Yazarlar:

Mahsa ESMAEİLLU

Yayıncı:

Erkan YULA

Ana Başlıklar:

Hastalıklar

Dergi:

Journal of Immunology and Clinical Microbiology 2016 Vol.1 Issue 1, pp.10-13

Belge Tipi:

Makale

Yayın Tarihi:

5/2016

Belge Dili:

İngilizce

Document ID (Org No.):

2000741013

Sıklık:

Üç Aylık

eISSN:

2528-9470

DOI:

https://doi.org/10.5455/jicm.5.20160514