Adherence to Nucleoside/Nucleotide Analogue Treatment in  Patients with Chronic Hepatitis B

Emin Ediz TÜTÜNCÜ; Rahmet GÜNER; Yunus GÜRBÜZ; Ayşe Kaya KALEM; Barış ÖZTÜRK; İmran HASANOĞLU; İrfan ŞENCAN; Mehmet A. TAŞYARAN

Makale detayları

Adherence to Nucleoside/Nucleotide Analogue Treatment in Patients with Chronic Hepatitis B

Yazarlar:

Emin Ediz TÜTÜNCÜ | Rahmet GÜNER | Yunus GÜRBÜZ | Ayşe Kaya KALEM | Barış ÖZTÜRK | İmran HASANOĞLU | İrfan ŞENCAN | Mehmet A. TAŞYARAN

Yayıncı:

Trakya University

Dergi:

Balkan Medical Journal 2017 Vol.34 Issue 6, pp.540-545

Belge Tipi:

Makale

Yayın Tarihi:

10/2017

Belge Dili:

Türkçe

Document ID (Org No.):

2000758979

Sıklık:

İki Aylık

pISSN:

2146-3123

Özet:

 

Background: Adherence to medication is an important aspect of preventing drug resistance and treatment failure in patients receiving nucleos(t)ide analogues for chronic hepatitis B. Aims: To assess adherence to nucleoside/nucleotide analogues in chronic hepatitis B treatment and to determine factors associated with non-adherence. Study Design: Cross-sectional study. Methods: The study enrolled 85 chronic hepatitis B patients who had been receiving nucleoside/nucleotide analogues for ≥3 months. A questionnaire was completed by patients themselves, and adherence was evaluated based on patients’ self-reporting. The use of at least 95% of the drugs in the previous month was considered as adequate adherence. Results: Adherence was adequate in 82.4% of patients. Female gender (p=0.003), unemployment (p=0.041) and lower monthly family income (p=0.001) were related to lower adherence. Better adherence was significantly linked to adequate basic knowledge regarding chronic hepatitis B (p=0.049), longer treatment duration than 12 months (p<0.001), previous use of other medications for chronic hepatitis B (p=0.014) and regular follow-up by the same physician (p<0.001). Conclusion: Counselling patients about their disease state and the consequences of non-adherence is an important intervention for enhancing adherence. Naïve patients should be followed up more frequently to reinforce adherence.

Makale detayları

Adherence to Nucleoside/Nucleotide Analogue Treatment in Patients with Chronic Hepatitis B

Yazarlar: Emin Ediz TÜTÜNCÜ | Rahmet GÜNER | Yunus GÜRBÜZ | Ayşe Kaya KALEM | Barış ÖZTÜRK | İmran HASANOĞLU | İrfan ŞENCAN | Mehmet A. TAŞYARAN

Yayıncı: Trakya University

Dergi: Balkan Medical Journal 2017 Vol.34 Issue 6, pp.540-545

Belge Tipi: Makale

Yayın Tarihi: 10/2017

Belge Dili: Türkçe

Document ID (Org No.): 2000758979

Sıklık: İki Aylık

pISSN: 2146-3123

Sayı

Yazarlar:

Emin Ediz TÜTÜNCÜ | Rahmet GÜNER | Yunus GÜRBÜZ | Ayşe Kaya KALEM | Barış ÖZTÜRK | İmran HASANOĞLU | İrfan ŞENCAN | Mehmet A. TAŞYARAN

Yayıncı:

Trakya University

Dergi:

Balkan Medical Journal 2017 Vol.34 Issue 6, pp.540-545

Belge Tipi:

Makale

Yayın Tarihi:

10/2017

Belge Dili:

Türkçe

Document ID (Org No.):

2000758979

Sıklık:

İki Aylık

pISSN:

2146-3123