Electro-oxidation of some non-steroidal anti-inflammatory drugs on an alumina nanoparticle-modified glassy carbon electrode

Mahla TABESHNIA; Hossein HELI; Ali JABBARI

Makale detayları

Electro-oxidation of some non-steroidal anti-inflammatory drugs on an alumina nanoparticle-modified glassy carbon electrode

Yazarlar:

Mahla TABESHNIA | Hossein HELI | Ali JABBARI

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2010 Vol.34 Issue 1, pp.35-46

Belge Tipi:

Makale

Yayın Tarihi:

12/2009

Belge Dili:

Türkçe

Document ID (Org No.):

2000728134

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

Özet:

 

The electro-oxidation of mefenamic acid, diclofenac, and  indomethacin on glassy carbon and alumina nanoparticle-modified glassy  carbon electrodes in a phosphate buffer solution at physiological pH  was studied.  The techniques of cyclic voltammetry, chronoamperometry,  impedance spectroscopy, and steady state polarization measurements  were applied.  The drugs were irreversibly oxidized on bath electrodes  via an anodic peak and the process was controlled by diffusion in the  bulk of solution.  Alumina nanoparticles increased the oxidation  current, and lowered the peak and onset potentials.  As such, alumina  nanoparticles had an electrocatalytic effect, both kinetically and  thermodynamically.  The kinetic parameters of heterogeneous electron  transfer and diffusion coefficients of the drugs are reported.

 

The electro-oxidation of mefenamic acid, diclofenac, and  indomethacin on glassy carbon and alumina nanoparticle-modified glassy  carbon electrodes in a phosphate buffer solution at physiological pH  was studied.  The techniques of cyclic voltammetry, chronoamperometry,  impedance spectroscopy, and steady state polarization measurements  were applied.  The drugs were irreversibly oxidized on bath electrodes  via an anodic peak and the process was controlled by diffusion in the  bulk of solution.  Alumina nanoparticles increased the oxidation  current, and lowered the peak and onset potentials.  As such, alumina  nanoparticles had an electrocatalytic effect, both kinetically and  thermodynamically.  The kinetic parameters of heterogeneous electron  transfer and diffusion coefficients of the drugs are reported.

Makale detayları

Electro-oxidation of some non-steroidal anti-inflammatory drugs on an alumina nanoparticle-modified glassy carbon electrode

Yazarlar: Mahla TABESHNIA | Hossein HELI | Ali JABBARI

Yayıncı: TUBITAK

Dergi: Turkish Journal of Chemistry 2010 Vol.34 Issue 1, pp.35-46

Belge Tipi: Makale

Yayın Tarihi: 12/2009

Belge Dili: Türkçe

Document ID (Org No.): 2000728134

Sıklık: İki Aylık

eISSN: 1303-6130

pISSN: 1300-0527

Sayı

Yazarlar:

Mahla TABESHNIA | Hossein HELI | Ali JABBARI

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2010 Vol.34 Issue 1, pp.35-46

Belge Tipi:

Makale

Yayın Tarihi:

12/2009

Belge Dili:

Türkçe

Document ID (Org No.):

2000728134

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527