The assessment of effectiveness of a novel antidepressant, Agomelatine on anxiety and depression induced by fluoride intoxication by means of Open-Field and Hot-Plate tests in mouse model (BalB-C)

Başaran Karademir

Makale detayları

The assessment of effectiveness of a novel antidepressant, Agomelatine on anxiety and depression induced by fluoride intoxication by means of Open-Field and Hot-Plate tests in mouse model (BalB-C)

Yazarlar:

Başaran Karademir

Yayıncı:

Ankara University

Ana Başlıklar:

Veterinary Surgery

Dergi:

Ankara Üniversitesi Veteriner Fakültesi Dergisi Vol.70 Issue 2, pp.123-130

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001285437

pISSN:

1300-0861

Anahtar kelimeler:

Özet:

 It is well known that fluoride F poisoning causes anxiety and depression, and Agomelatine, an analogue of melatonin, has been reported to be effective on anxiety and depression. Therefore, the aim of this study is to investigate the short-term efficacy of Agomelatine application on anxiety and depression caused by F intoxication via Open-Field and Hot-Plate tests. Forty male BalB-C mice, aged 5-6 months, constituted the research material for this study. Subjects were randomly divided into 4 groups Healthy-Control, Fluorosis-Control, 25 mgkg Agomelatine, 50 mgkg Agomelatine. Healthy-Control group HC received tap water, containing 0.3  0.05 mgFL. Fluorosis-Control group F received drinking water containing 40 mgFL. Other two experimental groups 25 and 50 received drinking water containing 40 mgFL and a single dose of Agomelatine 25 and 50 mgkg respectively. The effect of Agomelatine on anxiety and depression induced by high dose F was evaluated using Open-Field and Hot-Plate tests compared to control groups. Fluorosis caused to decrease in Rearing, Grooming and Square numbers of Open-Field test and to increase Defecation counts P0.05. Agolematine applications enabled to normalize the Open-Field Test data. Similarly, according to the Hot-Plate findings, low reaction time caused by fluorosis increased in Agomelatine groups P0.05. According to those results, psychological improvement was observed in patients with fluorosis compared to the control group after Agomelatine applications. Consequently, according to Open-Field and Hot-Plate tests findings, it could be concluded that Agomelatine has a curative effect on anxiety and depression induced by F toxicity.

 It is well known that fluoride F poisoning causes anxiety and depression, and Agomelatine, an analogue of melatonin, has been reported to be effective on anxiety and depression. Therefore, the aim of this study is to investigate the short-term efficacy of Agomelatine application on anxiety and depression caused by F intoxication via Open-Field and Hot-Plate tests. Forty male BalB-C mice, aged 5-6 months, constituted the research material for this study. Subjects were randomly divided into 4 groups Healthy-Control, Fluorosis-Control, 25 mgkg Agomelatine, 50 mgkg Agomelatine. Healthy-Control group HC received tap water, containing 0.3  0.05 mgFL. Fluorosis-Control group F received drinking water containing 40 mgFL. Other two experimental groups 25 and 50 received drinking water containing 40 mgFL and a single dose of Agomelatine 25 and 50 mgkg respectively. The effect of Agomelatine on anxiety and depression induced by high dose F was evaluated using Open-Field and Hot-Plate tests compared to control groups. Fluorosis caused to decrease in Rearing, Grooming and Square numbers of Open-Field test and to increase Defecation counts P0.05. Agolematine applications enabled to normalize the Open-Field Test data. Similarly, according to the Hot-Plate findings, low reaction time caused by fluorosis increased in Agomelatine groups P0.05. According to those results, psychological improvement was observed in patients with fluorosis compared to the control group after Agomelatine applications. Consequently, according to Open-Field and Hot-Plate tests findings, it could be concluded that Agomelatine has a curative effect on anxiety and depression induced by F toxicity.

 It is well known that fluoride F poisoning causes anxiety and depression, and Agomelatine, an analogue of melatonin, has been reported to be effective on anxiety and depression. Therefore, the aim of this study is to investigate the short-term efficacy of Agomelatine application on anxiety and depression caused by F intoxication via Open-Field and Hot-Plate tests. Forty male BalB-C mice, aged 5-6 months, constituted the research material for this study. Subjects were randomly divided into 4 groups Healthy-Control, Fluorosis-Control, 25 mgkg Agomelatine, 50 mgkg Agomelatine. Healthy-Control group HC received tap water, containing 0.3  0.05 mgFL. Fluorosis-Control group F received drinking water containing 40 mgFL. Other two experimental groups 25 and 50 received drinking water containing 40 mgFL and a single dose of Agomelatine 25 and 50 mgkg respectively. The effect of Agomelatine on anxiety and depression induced by high dose F was evaluated using Open-Field and Hot-Plate tests compared to control groups. Fluorosis caused to decrease in Rearing, Grooming and Square numbers of Open-Field test and to increase Defecation counts P0.05. Agolematine applications enabled to normalize the Open-Field Test data. Similarly, according to the Hot-Plate findings, low reaction time caused by fluorosis increased in Agomelatine groups P0.05. According to those results, psychological improvement was observed in patients with fluorosis compared to the control group after Agomelatine applications. Consequently, according to Open-Field and Hot-Plate tests findings, it could be concluded that Agomelatine has a curative effect on anxiety and depression induced by F toxicity.

 It is well known that fluoride F poisoning causes anxiety and depression, and Agomelatine, an analogue of melatonin, has been reported to be effective on anxiety and depression. Therefore, the aim of this study is to investigate the short-term efficacy of Agomelatine application on anxiety and depression caused by F intoxication via Open-Field and Hot-Plate tests. Forty male BalB-C mice, aged 5-6 months, constituted the research material for this study. Subjects were randomly divided into 4 groups Healthy-Control, Fluorosis-Control, 25 mgkg Agomelatine, 50 mgkg Agomelatine. Healthy-Control group HC received tap water, containing 0.3  0.05 mgFL. Fluorosis-Control group F received drinking water containing 40 mgFL. Other two experimental groups 25 and 50 received drinking water containing 40 mgFL and a single dose of Agomelatine 25 and 50 mgkg respectively. The effect of Agomelatine on anxiety and depression induced by high dose F was evaluated using Open-Field and Hot-Plate tests compared to control groups. Fluorosis caused to decrease in Rearing, Grooming and Square numbers of Open-Field test and to increase Defecation counts P0.05. Agolematine applications enabled to normalize the Open-Field Test data. Similarly, according to the Hot-Plate findings, low reaction time caused by fluorosis increased in Agomelatine groups P0.05. According to those results, psychological improvement was observed in patients with fluorosis compared to the control group after Agomelatine applications. Consequently, according to Open-Field and Hot-Plate tests findings, it could be concluded that Agomelatine has a curative effect on anxiety and depression induced by F toxicity.

Makale detayları

The assessment of effectiveness of a novel antidepressant, Agomelatine on anxiety and depression induced by fluoride intoxication by means of Open-Field and Hot-Plate tests in mouse model (BalB-C)

Yazarlar:

Başaran Karademir

Yayıncı:

Ankara University

Ana Başlıklar:

Veterinary Surgery

Dergi:

Ankara Üniversitesi Veteriner Fakültesi Dergisi Vol.70 Issue 2, pp.123-130

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001285437

pISSN:

1300-0861

Agomelatine

animal model

Fluorosis

mental disorder

Sayı

Makale detayları

The assessment of effectiveness of a novel antidepressant, Agomelatine on anxiety and depression induced by fluoride intoxication by means of Open-Field and Hot-Plate tests in mouse model (BalB-C)

Yazarlar: Başaran Karademir

Yayıncı: Ankara University

Ana Başlıklar: Veterinary Surgery

Dergi: Ankara Üniversitesi Veteriner Fakültesi Dergisi Vol.70 Issue 2, pp.123-130

Belge Tipi: Makale

Yayın Tarihi: 3/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001285437

pISSN: 1300-0861

Agomelatine

animal model

Fluorosis

mental disorder

Sayı

Yazarlar:

Başaran Karademir

Yayıncı:

Ankara University

Ana Başlıklar:

Veterinary Surgery

Dergi:

Ankara Üniversitesi Veteriner Fakültesi Dergisi Vol.70 Issue 2, pp.123-130

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001285437

pISSN:

1300-0861