The role of ultrasonographic hepatic artery resistive index in the diagnosis of insulin resistance in obese children with non-alcoholic fatty liver disease

Şamil HIZLI; Ali KOÇYİĞİT; Nur ARSLAN; Sedat TUNCEL; Fatih DEMİRCİOĞLU; Handan ÇAKMAKÇI; Benal BÜYÜKGEBİZ

Makale detayları

The role of ultrasonographic hepatic artery resistive index in the diagnosis of insulin resistance in obese children with non-alcoholic fatty liver disease

Yazarlar:

Şamil HIZLI | Ali KOÇYİĞİT | Nur ARSLAN | Sedat TUNCEL | Fatih DEMİRCİOĞLU | Handan ÇAKMAKÇI | Benal BÜYÜKGEBİZ

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2010 Vol.40 Issue 3, pp.335-342

Belge Tipi:

Makale

Yayın Tarihi:

2/2010

Belge Dili:

Türkçe

Document ID (Org No.):

2000755056

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

To determine the role of hepatic artery resistive index (HARI) measurement in the prediction of insulin resistance (IR) in obese children with nonalcoholic fatty liver disease (NAFLD).   Materials and methods: A total of 64 obese subjects with NAFLD (13.5 ± 1.36 years of age, 34 male) and 32 age- and gender-matched control subjects (13.8 ± 1.24 years of age, 16 male) were enrolled in the study. All subjects underwent a physical examination, laboratory tests, and ultrasonographic and Doppler examinations of the liver. The homeostasis model assessment of IR (HOMA-IR) was used for the IR diagnosis.   Results: Obese subjects with NAFLD had significantly higher HARI, insulin, alanine aminotransferase (ALT), total cholesterol (TC), triglycerides (TG), and HOMA-IR than the control subjects. Obese subjects with NAFLD and IR had significantly higher HARI compared to obese subjects with NAFLD but without IR (0.761 ± 0.04 vs. 0.732 ± 0.04, P = 0.006). Changes in HARI correlated significantly to changes in BMI, SDS-BMI, MAC, TSF, MAC, ALT, TC, insulin, and HOMA-IR (r = 0.578, P = 0.001; r = 0.547, P = 0.001; r = 0.549, P = 0.001; r = 0.504, P = 0.001; r = 0.549, P = 0.001; r = 0.223, P = 0.029; r = 0.306, P = 0.002; r = 0.315, P = 0.011; r = 0.295, P = 0.018, respectively). As an optimal cutoff point, a HARI level of 0.715 determined IR with 81.2% sensitivity and 71.9% specificity.  Conclusion: Our findings suggest that HARI might be used as a simple and non-invasive screening method to predict IR in obese children with NAFLD.

 

To determine the role of hepatic artery resistive index (HARI) measurement in the prediction of insulin resistance (IR) in obese children with nonalcoholic fatty liver disease (NAFLD).   Materials and methods: A total of 64 obese subjects with NAFLD (13.5 ± 1.36 years of age, 34 male) and 32 age- and gender-matched control subjects (13.8 ± 1.24 years of age, 16 male) were enrolled in the study. All subjects underwent a physical examination, laboratory tests, and ultrasonographic and Doppler examinations of the liver. The homeostasis model assessment of IR (HOMA-IR) was used for the IR diagnosis.   Results: Obese subjects with NAFLD had significantly higher HARI, insulin, alanine aminotransferase (ALT), total cholesterol (TC), triglycerides (TG), and HOMA-IR than the control subjects. Obese subjects with NAFLD and IR had significantly higher HARI compared to obese subjects with NAFLD but without IR (0.761 ± 0.04 vs. 0.732 ± 0.04, P = 0.006). Changes in HARI correlated significantly to changes in BMI, SDS-BMI, MAC, TSF, MAC, ALT, TC, insulin, and HOMA-IR (r = 0.578, P = 0.001; r = 0.547, P = 0.001; r = 0.549, P = 0.001; r = 0.504, P = 0.001; r = 0.549, P = 0.001; r = 0.223, P = 0.029; r = 0.306, P = 0.002; r = 0.315, P = 0.011; r = 0.295, P = 0.018, respectively). As an optimal cutoff point, a HARI level of 0.715 determined IR with 81.2% sensitivity and 71.9% specificity.  Conclusion: Our findings suggest that HARI might be used as a simple and non-invasive screening method to predict IR in obese children with NAFLD.

Makale detayları

The role of ultrasonographic hepatic artery resistive index in the diagnosis of insulin resistance in obese children with non-alcoholic fatty liver disease

Yazarlar:

Şamil HIZLI | Ali KOÇYİĞİT | Nur ARSLAN | Sedat TUNCEL | Fatih DEMİRCİOĞLU | Handan ÇAKMAKÇI | Benal BÜYÜKGEBİZ

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2010 Vol.40 Issue 3, pp.335-342

Belge Tipi:

Makale

Yayın Tarihi:

2/2010

Belge Dili:

Türkçe

Document ID (Org No.):

2000755056

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Key words: Obesity

insulin resistance

nonalcoholic fatty liver disease

hepatic artery resistive index

adolescent

Doppler ultrasonography

Sayı

Makale detayları

The role of ultrasonographic hepatic artery resistive index in the diagnosis of insulin resistance in obese children with non-alcoholic fatty liver disease

Yazarlar: Şamil HIZLI | Ali KOÇYİĞİT | Nur ARSLAN | Sedat TUNCEL | Fatih DEMİRCİOĞLU | Handan ÇAKMAKÇI | Benal BÜYÜKGEBİZ

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2010 Vol.40 Issue 3, pp.335-342

Belge Tipi: Makale

Yayın Tarihi: 2/2010

Belge Dili: Türkçe

Document ID (Org No.): 2000755056

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Key words: Obesity

insulin resistance

nonalcoholic fatty liver disease

hepatic artery resistive index

adolescent

Doppler ultrasonography

Sayı

Yazarlar:

Şamil HIZLI | Ali KOÇYİĞİT | Nur ARSLAN | Sedat TUNCEL | Fatih DEMİRCİOĞLU | Handan ÇAKMAKÇI | Benal BÜYÜKGEBİZ

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2010 Vol.40 Issue 3, pp.335-342

Belge Tipi:

Makale

Yayın Tarihi:

2/2010

Belge Dili:

Türkçe

Document ID (Org No.):

2000755056

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144