Understanding How Madecassic Acid Affects Glioblastoma Cells: Its Antioxidant and Anti-cancer Properties

Ufuk Okkay; Irmak Ferah Okkay; Fatma Yesilyurt; Selcuk Senyayla

Makale detayları

Understanding How Madecassic Acid Affects Glioblastoma Cells: Its Antioxidant and Anti-cancer Properties

Yazarlar:

Ufuk Okkay | Irmak Ferah Okkay | Fatma Yesilyurt | Selcuk Senyayla

Yayıncı:

Ataturk University

Ana Başlıklar:

Medical Pharmacology

Dergi:

Recent Trends in Pharmacology Vol.1 Issue 2, pp.63-71

Belge Tipi:

Makale

Yayın Tarihi:

8/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001294283

pISSN:

2980-194X

Anahtar kelimeler:

Özet:

 Glioblastoma, a malignant brain tumor, poses significant therapeutic challenges due to its aggressive nature and limited treatment options. The search for novel compounds with potential therapeutic efficacy against this devastating disease remains imperative. Madecassic acid MA, a triterpenoid derived from Centella asiatica, has emerged as a promising candidate with multifaceted pharmacological activities, including antioxidant and antitumor effects. However, its specific impact on glioblastoma cells necessitates further exploration to fully comprehend its therapeutic potential. In this investigation, we examined the effects of MA on a human glioblastoma cell line, with a primary focus on its antioxidant and anti-proliferative properties. Utilizing a comprehensive range of cellular and molecular assays, we unraveled the potential of MA in scavenging free radicals, mitigating oxidative stress, and inhibiting glioblastoma cell proliferation. The study revealed that MA significantly inhibited glioblastoma cell growth. Furthermore, MA-treated cells exhibited higher antioxidant enzyme activity and lower oxidative stress levels compared to untreated cells. These findings demonstrate the potential of MA as an effective therapeutic agent against glioblastoma. By elucidating its antioxidant and anti-proliferative effects, this research opens new avenues for innovative treatment strategies to combat this relentless brain tumor. The insights gained from this study may contribute to improved patient outcomes and revolutionize the landscape of glioblastoma therapy.

 Glioblastoma, a malignant brain tumor, poses significant therapeutic challenges due to its aggressive nature and limited treatment options. The search for novel compounds with potential therapeutic efficacy against this devastating disease remains imperative. Madecassic acid MA, a triterpenoid derived from Centella asiatica, has emerged as a promising candidate with multifaceted pharmacological activities, including antioxidant and antitumor effects. However, its specific impact on glioblastoma cells necessitates further exploration to fully comprehend its therapeutic potential. In this investigation, we examined the effects of MA on a human glioblastoma cell line, with a primary focus on its antioxidant and anti-proliferative properties. Utilizing a comprehensive range of cellular and molecular assays, we unraveled the potential of MA in scavenging free radicals, mitigating oxidative stress, and inhibiting glioblastoma cell proliferation. The study revealed that MA significantly inhibited glioblastoma cell growth. Furthermore, MA-treated cells exhibited higher antioxidant enzyme activity and lower oxidative stress levels compared to untreated cells. These findings demonstrate the potential of MA as an effective therapeutic agent against glioblastoma. By elucidating its antioxidant and anti-proliferative effects, this research opens new avenues for innovative treatment strategies to combat this relentless brain tumor. The insights gained from this study may contribute to improved patient outcomes and revolutionize the landscape of glioblastoma therapy.

 Glioblastoma, a malignant brain tumor, poses significant therapeutic challenges due to its aggressive nature and limited treatment options. The search for novel compounds with potential therapeutic efficacy against this devastating disease remains imperative. Madecassic acid MA, a triterpenoid derived from Centella asiatica, has emerged as a promising candidate with multifaceted pharmacological activities, including antioxidant and antitumor effects. However, its specific impact on glioblastoma cells necessitates further exploration to fully comprehend its therapeutic potential. In this investigation, we examined the effects of MA on a human glioblastoma cell line, with a primary focus on its antioxidant and anti-proliferative properties. Utilizing a comprehensive range of cellular and molecular assays, we unraveled the potential of MA in scavenging free radicals, mitigating oxidative stress, and inhibiting glioblastoma cell proliferation. The study revealed that MA significantly inhibited glioblastoma cell growth. Furthermore, MA-treated cells exhibited higher antioxidant enzyme activity and lower oxidative stress levels compared to untreated cells. These findings demonstrate the potential of MA as an effective therapeutic agent against glioblastoma. By elucidating its antioxidant and anti-proliferative effects, this research opens new avenues for innovative treatment strategies to combat this relentless brain tumor. The insights gained from this study may contribute to improved patient outcomes and revolutionize the landscape of glioblastoma therapy.

 Glioblastoma, a malignant brain tumor, poses significant therapeutic challenges due to its aggressive nature and limited treatment options. The search for novel compounds with potential therapeutic efficacy against this devastating disease remains imperative. Madecassic acid MA, a triterpenoid derived from Centella asiatica, has emerged as a promising candidate with multifaceted pharmacological activities, including antioxidant and antitumor effects. However, its specific impact on glioblastoma cells necessitates further exploration to fully comprehend its therapeutic potential. In this investigation, we examined the effects of MA on a human glioblastoma cell line, with a primary focus on its antioxidant and anti-proliferative properties. Utilizing a comprehensive range of cellular and molecular assays, we unraveled the potential of MA in scavenging free radicals, mitigating oxidative stress, and inhibiting glioblastoma cell proliferation. The study revealed that MA significantly inhibited glioblastoma cell growth. Furthermore, MA-treated cells exhibited higher antioxidant enzyme activity and lower oxidative stress levels compared to untreated cells. These findings demonstrate the potential of MA as an effective therapeutic agent against glioblastoma. By elucidating its antioxidant and anti-proliferative effects, this research opens new avenues for innovative treatment strategies to combat this relentless brain tumor. The insights gained from this study may contribute to improved patient outcomes and revolutionize the landscape of glioblastoma therapy.

Makale detayları

Understanding How Madecassic Acid Affects Glioblastoma Cells: Its Antioxidant and Anti-cancer Properties

Yazarlar:

Ufuk Okkay | Irmak Ferah Okkay | Fatma Yesilyurt | Selcuk Senyayla

Yayıncı:

Ataturk University

Ana Başlıklar:

Medical Pharmacology

Dergi:

Recent Trends in Pharmacology Vol.1 Issue 2, pp.63-71

Belge Tipi:

Makale

Yayın Tarihi:

8/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001294283

pISSN:

2980-194X

cell viability

glioblastoma cell line

GBM

madecassic acid

oxidative stress.

Sayı

Makale detayları

Understanding How Madecassic Acid Affects Glioblastoma Cells: Its Antioxidant and Anti-cancer Properties

Yazarlar: Ufuk Okkay | Irmak Ferah Okkay | Fatma Yesilyurt | Selcuk Senyayla

Yayıncı: Ataturk University

Ana Başlıklar: Medical Pharmacology

Dergi: Recent Trends in Pharmacology Vol.1 Issue 2, pp.63-71

Belge Tipi: Makale

Yayın Tarihi: 8/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001294283

pISSN: 2980-194X

cell viability

glioblastoma cell line

GBM

madecassic acid

oxidative stress.

Sayı

Yazarlar:

Ufuk Okkay | Irmak Ferah Okkay | Fatma Yesilyurt | Selcuk Senyayla

Yayıncı:

Ataturk University

Ana Başlıklar:

Medical Pharmacology

Dergi:

Recent Trends in Pharmacology Vol.1 Issue 2, pp.63-71

Belge Tipi:

Makale

Yayın Tarihi:

8/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001294283

pISSN:

2980-194X