Evaluation of the Clinical Effect of Hyaluronic Acid Mouthwash on Palatal Secondary Wound Healing in Diabetic Rats

Sibel Demirci Delipınar; Leyla Kuru; Hatice Selin Yıldırım

Makale detayları

Evaluation of the Clinical Effect of Hyaluronic Acid Mouthwash on Palatal Secondary Wound Healing in Diabetic Rats

Yazarlar:

Sibel Demirci Delipınar | Leyla Kuru | Hatice Selin Yıldırım

Yayıncı:

Marmara University

Ana Başlıklar:

Periodontics

Dergi:

Clinical and Experimental Health Sciences Vol.13 Issue 4, pp.748-752

Belge Tipi:

Makale

Yayın Tarihi:

12/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001298494

pISSN:

2459-1459

Anahtar kelimeler:

Özet:

 Objective: The objective of this study was to investigate clinical effect of topically administered hyaluronic acid HA mouthwash on healing of secondary palatal wound in diabetic D rats. Methods: 60 Wistar albino male rats were divided into D and non-diabetic ND groups. Diabetes was induced to 30 randomly selected rats by initially administering 110 mgkg of nicotinamide intraperitoneally, followed by 15 min of intraperitoneal injection of 65 mgkg of streptozotocin solution. 5 mm excisional wounds were made in the centre of the palate. After that, 6 animals from each group were sacrificed. Then, both groups were subdivided into two groups: 0.12 HA mouthwash and saline S n12 per group, depending on the agent to be administered to the wound area WA. On days 7 and 14, six rats from each group were sacrificed, and the WAs were measured through photographic measurements utilizing Image J software. Results: The WA decreased with time in each group p0.05. A significant difference was detected in the intergroup comparison of the WA on days 7 and 14 p0.05. On days 7 and 14, the smallest WA was observed in the ND-HA group, while the largest was in the D-S group p0.05. On day 14, the WA of both HA groups was similar p0.05 and smaller than that of both S groups p0.05. Conclusion: Topical application of HA mouthwash effectively improved secondary wound healing and reduced WA in D and ND rats. Thus, topical application of HA can be used in diabetic palatal secondary wound healing.

 Objective: The objective of this study was to investigate clinical effect of topically administered hyaluronic acid HA mouthwash on healing of secondary palatal wound in diabetic D rats. Methods: 60 Wistar albino male rats were divided into D and non-diabetic ND groups. Diabetes was induced to 30 randomly selected rats by initially administering 110 mgkg of nicotinamide intraperitoneally, followed by 15 min of intraperitoneal injection of 65 mgkg of streptozotocin solution. 5 mm excisional wounds were made in the centre of the palate. After that, 6 animals from each group were sacrificed. Then, both groups were subdivided into two groups: 0.12 HA mouthwash and saline S n12 per group, depending on the agent to be administered to the wound area WA. On days 7 and 14, six rats from each group were sacrificed, and the WAs were measured through photographic measurements utilizing Image J software. Results: The WA decreased with time in each group p0.05. A significant difference was detected in the intergroup comparison of the WA on days 7 and 14 p0.05. On days 7 and 14, the smallest WA was observed in the ND-HA group, while the largest was in the D-S group p0.05. On day 14, the WA of both HA groups was similar p0.05 and smaller than that of both S groups p0.05. Conclusion: Topical application of HA mouthwash effectively improved secondary wound healing and reduced WA in D and ND rats. Thus, topical application of HA can be used in diabetic palatal secondary wound healing.

 Objective: The objective of this study was to investigate clinical effect of topically administered hyaluronic acid HA mouthwash on healing of secondary palatal wound in diabetic D rats. Methods: 60 Wistar albino male rats were divided into D and non-diabetic ND groups. Diabetes was induced to 30 randomly selected rats by initially administering 110 mgkg of nicotinamide intraperitoneally, followed by 15 min of intraperitoneal injection of 65 mgkg of streptozotocin solution. 5 mm excisional wounds were made in the centre of the palate. After that, 6 animals from each group were sacrificed. Then, both groups were subdivided into two groups: 0.12 HA mouthwash and saline S n12 per group, depending on the agent to be administered to the wound area WA. On days 7 and 14, six rats from each group were sacrificed, and the WAs were measured through photographic measurements utilizing Image J software. Results: The WA decreased with time in each group p0.05. A significant difference was detected in the intergroup comparison of the WA on days 7 and 14 p0.05. On days 7 and 14, the smallest WA was observed in the ND-HA group, while the largest was in the D-S group p0.05. On day 14, the WA of both HA groups was similar p0.05 and smaller than that of both S groups p0.05. Conclusion: Topical application of HA mouthwash effectively improved secondary wound healing and reduced WA in D and ND rats. Thus, topical application of HA can be used in diabetic palatal secondary wound healing.

 Objective: The objective of this study was to investigate clinical effect of topically administered hyaluronic acid HA mouthwash on healing of secondary palatal wound in diabetic D rats. Methods: 60 Wistar albino male rats were divided into D and non-diabetic ND groups. Diabetes was induced to 30 randomly selected rats by initially administering 110 mgkg of nicotinamide intraperitoneally, followed by 15 min of intraperitoneal injection of 65 mgkg of streptozotocin solution. 5 mm excisional wounds were made in the centre of the palate. After that, 6 animals from each group were sacrificed. Then, both groups were subdivided into two groups: 0.12 HA mouthwash and saline S n12 per group, depending on the agent to be administered to the wound area WA. On days 7 and 14, six rats from each group were sacrificed, and the WAs were measured through photographic measurements utilizing Image J software. Results: The WA decreased with time in each group p0.05. A significant difference was detected in the intergroup comparison of the WA on days 7 and 14 p0.05. On days 7 and 14, the smallest WA was observed in the ND-HA group, while the largest was in the D-S group p0.05. On day 14, the WA of both HA groups was similar p0.05 and smaller than that of both S groups p0.05. Conclusion: Topical application of HA mouthwash effectively improved secondary wound healing and reduced WA in D and ND rats. Thus, topical application of HA can be used in diabetic palatal secondary wound healing.

Makale detayları

Evaluation of the Clinical Effect of Hyaluronic Acid Mouthwash on Palatal Secondary Wound Healing in Diabetic Rats

Yazarlar:

Sibel Demirci Delipınar | Leyla Kuru | Hatice Selin Yıldırım

Yayıncı:

Marmara University

Ana Başlıklar:

Periodontics

Dergi:

Clinical and Experimental Health Sciences Vol.13 Issue 4, pp.748-752

Belge Tipi:

Makale

Yayın Tarihi:

12/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001298494

pISSN:

2459-1459

Wound healing

diabetes mellitus

hyaluronic acid

rat

palate

Sayı

Makale detayları

Evaluation of the Clinical Effect of Hyaluronic Acid Mouthwash on Palatal Secondary Wound Healing in Diabetic Rats

Yazarlar: Sibel Demirci Delipınar | Leyla Kuru | Hatice Selin Yıldırım

Yayıncı: Marmara University

Ana Başlıklar: Periodontics

Dergi: Clinical and Experimental Health Sciences Vol.13 Issue 4, pp.748-752

Belge Tipi: Makale

Yayın Tarihi: 12/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001298494

pISSN: 2459-1459

Wound healing

diabetes mellitus

hyaluronic acid

rat

palate

Sayı

Yazarlar:

Sibel Demirci Delipınar | Leyla Kuru | Hatice Selin Yıldırım

Yayıncı:

Marmara University

Ana Başlıklar:

Periodontics

Dergi:

Clinical and Experimental Health Sciences Vol.13 Issue 4, pp.748-752

Belge Tipi:

Makale

Yayın Tarihi:

12/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001298494

pISSN:

2459-1459