PHENOLIC CONTENT AND ANTIBACTERIAL ACTIVITY OF COTA PESTALOZZAE BOISS. AERIAL PARTS

Özge Yılmaz; Sunasibel Rızvanoğlu; Özlem Bahadır Acıkara

Makale detayları

PHENOLIC CONTENT AND ANTIBACTERIAL ACTIVITY OF COTA PESTALOZZAE BOISS. AERIAL PARTS

Yazarlar:

Özge Yılmaz | Sunasibel Rızvanoğlu | Özlem Bahadır Acıkara

Yayıncı:

Ankara University

Ana Başlıklar:

Farmakognozi

Dergi:

Ankara Üniversitesi Eczacılık Fakültesi Dergisi Vol.49 Issue 2, pp.264-270

Belge Tipi:

Makale

Yayın Tarihi:

5/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347666

pISSN:

1015-3918

Anahtar kelimeler:

Özet:

 Objective: The genus Cota was once considered a subgenus of Anthemis but is now recognized as an independent genus. The species belonging to Cota, including several endemic to Turkey, have been less extensively studied in the literature than other plants in the Asteraceae family. The current study aimed to examine the phenolic content and antibacterial activity of C. pestalozzae Boiss., an endemic species from Turkey. Material and Method: The phenolic content of the methanol extract prepared from the aerial parts of C. pestalozzae Boiss. was analysed qualitatively and quantitatively using high-performance liquid chromatography HPLC analysis. This study calculated the limit of detection LOD and quantification LOQ for each detected compound. The antibacterial activity of the extract was also investigated against some Gram  and - bacteria strains. Result and Discussion: In the current study, chlorogenic acid, 4,5-O-dicaffeoyl quinic acid, 3,5-O-dicaffeoyl quinic acid, rutin, hyperoside and isoquercetin were qualitatively and quantitatively detected in the methanolic extract of the aerial parts of C. pestalozzae Boiss. Extract of the aerial parts exhibited antibacterial activity only against Staphylococcus aureus ATCC 43300 MRSA with a MIC value of 10000 µgml. The research indicates that C. pestalozzae contains phenolic compounds and is effective against Gram  bacteria.

 Objective: The genus Cota was once considered a subgenus of Anthemis but is now recognized as an independent genus. The species belonging to Cota, including several endemic to Turkey, have been less extensively studied in the literature than other plants in the Asteraceae family. The current study aimed to examine the phenolic content and antibacterial activity of C. pestalozzae Boiss., an endemic species from Turkey. Material and Method: The phenolic content of the methanol extract prepared from the aerial parts of C. pestalozzae Boiss. was analysed qualitatively and quantitatively using high-performance liquid chromatography HPLC analysis. This study calculated the limit of detection LOD and quantification LOQ for each detected compound. The antibacterial activity of the extract was also investigated against some Gram  and - bacteria strains. Result and Discussion: In the current study, chlorogenic acid, 4,5-O-dicaffeoyl quinic acid, 3,5-O-dicaffeoyl quinic acid, rutin, hyperoside and isoquercetin were qualitatively and quantitatively detected in the methanolic extract of the aerial parts of C. pestalozzae Boiss. Extract of the aerial parts exhibited antibacterial activity only against Staphylococcus aureus ATCC 43300 MRSA with a MIC value of 10000 µgml. The research indicates that C. pestalozzae contains phenolic compounds and is effective against Gram  bacteria.

 Objective: The genus Cota was once considered a subgenus of Anthemis but is now recognized as an independent genus. The species belonging to Cota, including several endemic to Turkey, have been less extensively studied in the literature than other plants in the Asteraceae family. The current study aimed to examine the phenolic content and antibacterial activity of C. pestalozzae Boiss., an endemic species from Turkey. Material and Method: The phenolic content of the methanol extract prepared from the aerial parts of C. pestalozzae Boiss. was analysed qualitatively and quantitatively using high-performance liquid chromatography HPLC analysis. This study calculated the limit of detection LOD and quantification LOQ for each detected compound. The antibacterial activity of the extract was also investigated against some Gram  and - bacteria strains. Result and Discussion: In the current study, chlorogenic acid, 4,5-O-dicaffeoyl quinic acid, 3,5-O-dicaffeoyl quinic acid, rutin, hyperoside and isoquercetin were qualitatively and quantitatively detected in the methanolic extract of the aerial parts of C. pestalozzae Boiss. Extract of the aerial parts exhibited antibacterial activity only against Staphylococcus aureus ATCC 43300 MRSA with a MIC value of 10000 µgml. The research indicates that C. pestalozzae contains phenolic compounds and is effective against Gram  bacteria.

 Amaç: Cota cinsi, Anthemis cinsinin alt türleri arasında sınıflandırılırken günümüzde ayrı bir cins olarak kabul edilmektedir. Türkiyede de endemik türleri bulunan Cota cinsine ait türler literatürde diğer Asteracea bitkilerine kıyasla daha az çalışılmıştır. Bu çalışmada, Türkiyede endemik bir tür olan C. pestalozzae Boiis. türünün fenolik içeriği ve antibakteriyel aktivitesinin araştırılması amaçlanmıştır. Gereç ve Yöntem: C. pestalozzae Boiss. türünün toprak üstü kısmından hazırlanan metanollü ekstrenin fenolik içeriği Yüksek Performanslı Sıvı Kromatografisi HPLC analizi ile kalitatif ve kantitatif olarak analiz edilmiştir. Bu çalışmada, tespit edilen bileşiklerin her biri için tespit limiti ve tayin limiti hesaplanmıştır. Ayrıca ekstrenin antibakteriyel aktivitesi bazı Gram  ve - bakteri türlerine karşı araştırılmıştır. Sonuç ve Tartışma: Yapılan çalışma, C. pestalozzae Boiss. bitkisinin toprak üstü kısmının metanollü ekstresinde klorojenik asit, 4,5-O-dikafeoil kinik asit, 3,5-O-dikafeoil kinik asit, rutin, hiperozit ve izokersetin kalitatif ve kantitatif olarak tespit edilmiştir. C. pestalozzae toprak üstü kısmı ekstresi sadece Staphylococcus aureus ATCC 43300e MRSA karşı 10000 µgml MIC değeri ile antibakteriyel aktivite sergilemiştir. Çalışma sonuçları C. pestalozzaenin fenolik bileşikler içerdiğini ve Gram  bakterilere karşı etkili olduğu göstermiştir.

Makale detayları

PHENOLIC CONTENT AND ANTIBACTERIAL ACTIVITY OF COTA PESTALOZZAE BOISS. AERIAL PARTS

Yazarlar:

Özge Yılmaz | Sunasibel Rızvanoğlu | Özlem Bahadır Acıkara

Yayıncı:

Ankara University

Ana Başlıklar:

Farmakognozi

Dergi:

Ankara Üniversitesi Eczacılık Fakültesi Dergisi Vol.49 Issue 2, pp.264-270

Belge Tipi:

Makale

Yayın Tarihi:

5/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347666

pISSN:

1015-3918

Antibacterial activity

Asteraceae

Cota

flavonoids

HPLC

phenolic acidsAntibakteriyel aktivite

Asteraceae

Cota

fenolik asitler

flavonoitler

HPLC

Sayı

Makale detayları

Yazarlar: Özge Yılmaz | Sunasibel Rızvanoğlu | Özlem Bahadır Acıkara

Yayıncı: Ankara University

Ana Başlıklar: Farmakognozi

Dergi: Ankara Üniversitesi Eczacılık Fakültesi Dergisi Vol.49 Issue 2, pp.264-270

Belge Tipi: Makale

Yayın Tarihi: 5/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001347666

pISSN: 1015-3918

Sayı

Yazarlar:

Özge Yılmaz | Sunasibel Rızvanoğlu | Özlem Bahadır Acıkara

Yayıncı:

Ankara University

Ana Başlıklar:

Farmakognozi

Dergi:

Ankara Üniversitesi Eczacılık Fakültesi Dergisi Vol.49 Issue 2, pp.264-270

Belge Tipi:

Makale

Yayın Tarihi:

5/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347666

pISSN:

1015-3918