Accelerated Achilles tendon healing with interleukin-1 receptor antagonist protein in rabbits

Marko PECIN; Mario KRESZINGER; Snjezana VUKOVIC; Marija LIPAR; Ozren SMOLEC; Berislav RADISIC; Josip KOS

Makale detayları

Accelerated Achilles tendon healing with interleukin-1 receptor antagonist protein in rabbits

Yazarlar:

Marko PECIN | Mario KRESZINGER | Snjezana VUKOVIC | Marija LIPAR | Ozren SMOLEC | Berislav RADISIC | Josip KOS

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Veterinary and Animal Sciences 2017 Vol.41 Issue 1, pp.118-126

Belge Tipi:

Makale

Yayın Tarihi:

2/2017

Belge Dili:

İngilizce

Document ID (Org No.):

2000765145

Sıklık:

İki Aylık

eISSN:

1303-6181

pISSN:

1300-0128

Özet:

 

The current study describes the use of interleukin-1 receptor antagonist protein (IL-1Ra) as a possible strategy for optimizing tendon healing and repair by presenting histologically visible changes in rabbit Achilles tendon tissue after longitudinal tenotomy. The study was carried out on 26 Californian rabbits divided into two equal groups. One was the experimental IRAP (interleukin-1 receptor antagonist) group and the second one was the PBS (purified buffered saline) group. The PBS group was the control group. After longitudinal tenotomy in both groups of rabbits, in the IRAP group IL-1Ra was applied locally, whereas PBS was applied in the control group. IL-1 concentration in Achilles tendon tissue was measured with an ELISA IL-1 rabbit kit. Local application of IL-1Ra resulted in 2.5-fold lower IL-1 tissue concentration and prevented cytokine cascade activation and its proinflammatory effects. Consequently, it prevented chronic tendon inflammation and improved Achilles tendon healing in rabbits. Histological changes in tendon tissue samples were evaluated by Bonar scale score with statistically significant differences between groups (P ≤ 0.01).

Makale detayları

Accelerated Achilles tendon healing with interleukin-1 receptor antagonist protein in rabbits

Yazarlar: Marko PECIN | Mario KRESZINGER | Snjezana VUKOVIC | Marija LIPAR | Ozren SMOLEC | Berislav RADISIC | Josip KOS

Yayıncı: TUBITAK

Dergi: Turkish Journal of Veterinary and Animal Sciences 2017 Vol.41 Issue 1, pp.118-126

Belge Tipi: Makale

Yayın Tarihi: 2/2017

Belge Dili: İngilizce

Document ID (Org No.): 2000765145

Sıklık: İki Aylık

eISSN: 1303-6181

pISSN: 1300-0128

Sayı

Yazarlar:

Marko PECIN | Mario KRESZINGER | Snjezana VUKOVIC | Marija LIPAR | Ozren SMOLEC | Berislav RADISIC | Josip KOS

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Veterinary and Animal Sciences 2017 Vol.41 Issue 1, pp.118-126

Belge Tipi:

Makale

Yayın Tarihi:

2/2017

Belge Dili:

İngilizce

Document ID (Org No.):

2000765145

Sıklık:

İki Aylık

eISSN:

1303-6181

pISSN:

1300-0128