Alteration of cerebral perfusion and cortical thickness in depression episodes: a comparative MRI study

Özkan KILINÇ; Mustafa HIZAL; Özden ARISOY; Nur ÖZGEDİK; Oya KALAYCIOĞLU

doi:https://doi.org/10.32322/jhsm.993848

Makale detayları

Alteration of cerebral perfusion and cortical thickness in depression episodes: a comparative MRI study

Yazarlar:

Özkan KILINÇ | Mustafa HIZAL | Özden ARISOY | Nur ÖZGEDİK | Oya KALAYCIOĞLU

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Journal of Health Sciences and Medicine 2022 Vol.5 Issue 1, pp.38-44

Belge Tipi:

Makale

Yayın Tarihi:

1/2022

Belge Dili:

İngilizce

Document ID (Org No.):

2000481675

Sıklık:

İki Aylık

eISSN:

2636-8579

DOI:

https://doi.org/10.32322/jhsm.993848

Özet:

 

Aim: We aimed to determine the difference between cerebral perfusion and cortical thickness between first attack and recurrent in major depression patients.
Material and Method: Our study was conducted prospectively between 01.03.2017-03.03.2018 in Izzet Baysal University Psychiatry department. 40 patients (21 first episodes and 19 recurrent episodes) diagnosed with depression according to DSM 5 by the American Psychiatric Association and a control group of 16 healthy individuals were evaluated for cerebral blood flow and cortical thickness with Perfusion MRI. Patients were also evaluated by Hamilton depression rating scale.
Findings: The cortical thickness was significantly decreased in recurrent attacks.There was no significant difference of CBF in first episode and recurrent episodes, except cingulate cortex, which showed significantly reduced CBF values in recurrent group. In patients with higher Hamilton depression scale points, the CBF values of insular cortex were decreased.
Conclusion: These findings suggests that cortical atrophy and activation of default mode network in recurrent episodes which leads to decreased response to treatment.

Makale detayları

Alteration of cerebral perfusion and cortical thickness in depression episodes: a comparative MRI study

Yazarlar: Özkan KILINÇ | Mustafa HIZAL | Özden ARISOY | Nur ÖZGEDİK | Oya KALAYCIOĞLU

Yayıncı: MediHealth Academy Yayıncılık

Ana Başlıklar: Sağlık teşvikleri

Dergi: Journal of Health Sciences and Medicine 2022 Vol.5 Issue 1, pp.38-44

Belge Tipi: Makale

Yayın Tarihi: 1/2022

Belge Dili: İngilizce

Document ID (Org No.): 2000481675

Sıklık: İki Aylık

eISSN: 2636-8579

DOI: https://doi.org/10.32322/jhsm.993848

Sayı

Yazarlar:

Özkan KILINÇ | Mustafa HIZAL | Özden ARISOY | Nur ÖZGEDİK | Oya KALAYCIOĞLU

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Journal of Health Sciences and Medicine 2022 Vol.5 Issue 1, pp.38-44

Belge Tipi:

Makale

Yayın Tarihi:

1/2022

Belge Dili:

İngilizce

Document ID (Org No.):

2000481675

Sıklık:

İki Aylık

eISSN:

2636-8579

DOI:

https://doi.org/10.32322/jhsm.993848