Urodynamic evaluation of acute effects of sildenafil on voiding among males with erectile dysfunction and symptomatic benign prostate

Fatih Rüştü YALÇINKAYA; Mürsel DAVARCI; Soner AKÇİN; Ahmet GÖKÇE

Makale detayları

Urodynamic evaluation of acute effects of sildenafil on voiding among males with erectile dysfunction and symptomatic benign prostate

Yazarlar:

Fatih Rüştü YALÇINKAYA | Mürsel DAVARCI | Soner AKÇİN | Ahmet GÖKÇE

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2012 Vol.42 Issue 6, pp.951-956

Belge Tipi:

Makale

Yayın Tarihi:

5/2012

Belge Dili:

Türkçe

Document ID (Org No.):

2000753919

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

To evaluate the acute effects of sildenafil citrate on micturition of men with erectile dysfunction and symptomatic benign prostatic hyperplasia using urodynamic parameters.   Materials and methods: Between June and December 2009, a total of 50 patients over the age of 40 participated in the study. The patients were admitted to our hospital with erectile dysfunction and moderate to severe lower urinary symptoms with benign prostatic hyperplasia. To examine the sexual function of the participants, we used the IIEF-5 Sexual Health Inventory for Men questionnaire. Patients were randomly divided into 2 groups: a treatment group and a control group. A basal urodynamic evaluation was performed in both groups. After the urodynamic evaluation, 50 mg of sildenafil was given to the patients in the control group and 1 h later a second evaluation was performed. Following the urodynamic evaluation, a placebo was given to the patients in the control group and then a second evaluation was performed after 1 h.  Results: A statistically significant increase was seen in maximal flow and average flow (Qmax and Qave) after 1 h in the treatment group. The increase in the control group was not significant.  Conclusion: Based on the study findings, we suggest that sildenafil has an effect on micturition in the short term. However, to determine the role of sildenafil in the treatment of BPH/LUTS, further studies with larger patient groups are needed.

 

To evaluate the acute effects of sildenafil citrate on micturition of men with erectile dysfunction and symptomatic benign prostatic hyperplasia using urodynamic parameters.   Materials and methods: Between June and December 2009, a total of 50 patients over the age of 40 participated in the study. The patients were admitted to our hospital with erectile dysfunction and moderate to severe lower urinary symptoms with benign prostatic hyperplasia. To examine the sexual function of the participants, we used the IIEF-5 Sexual Health Inventory for Men questionnaire. Patients were randomly divided into 2 groups: a treatment group and a control group. A basal urodynamic evaluation was performed in both groups. After the urodynamic evaluation, 50 mg of sildenafil was given to the patients in the control group and 1 h later a second evaluation was performed. Following the urodynamic evaluation, a placebo was given to the patients in the control group and then a second evaluation was performed after 1 h.  Results: A statistically significant increase was seen in maximal flow and average flow (Qmax and Qave) after 1 h in the treatment group. The increase in the control group was not significant.  Conclusion: Based on the study findings, we suggest that sildenafil has an effect on micturition in the short term. However, to determine the role of sildenafil in the treatment of BPH/LUTS, further studies with larger patient groups are needed.

Makale detayları

Urodynamic evaluation of acute effects of sildenafil on voiding among males with erectile dysfunction and symptomatic benign prostate

Yazarlar:

Fatih Rüştü YALÇINKAYA | Mürsel DAVARCI | Soner AKÇİN | Ahmet GÖKÇE

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2012 Vol.42 Issue 6, pp.951-956

Belge Tipi:

Makale

Yayın Tarihi:

5/2012

Belge Dili:

Türkçe

Document ID (Org No.):

2000753919

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Key words: Benign prostatic hyperplasia

lower urinary tract symptoms

phosphodiesterase inhibitors

sildenafil

uroflowmetry

urodynamics

Sayı

Makale detayları

Urodynamic evaluation of acute effects of sildenafil on voiding among males with erectile dysfunction and symptomatic benign prostate

Yazarlar: Fatih Rüştü YALÇINKAYA | Mürsel DAVARCI | Soner AKÇİN | Ahmet GÖKÇE

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2012 Vol.42 Issue 6, pp.951-956

Belge Tipi: Makale

Yayın Tarihi: 5/2012

Belge Dili: Türkçe

Document ID (Org No.): 2000753919

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Key words: Benign prostatic hyperplasia

lower urinary tract symptoms

phosphodiesterase inhibitors

sildenafil

uroflowmetry

urodynamics

Sayı

Yazarlar:

Fatih Rüştü YALÇINKAYA | Mürsel DAVARCI | Soner AKÇİN | Ahmet GÖKÇE

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2012 Vol.42 Issue 6, pp.951-956

Belge Tipi:

Makale

Yayın Tarihi:

5/2012

Belge Dili:

Türkçe

Document ID (Org No.):

2000753919

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144