A SINGLE CENTRE EXPERIENCE OF LOW C3/C4 LEVELS AND OTHER LABORATORY ASPECTS IN TURKISH CHILDREN WITH IMMUNOGLOBULIN A VASCULITIS

Şeyda Doğantan; Sema Nur Taşkın

Makale detayları

A SINGLE CENTRE EXPERIENCE OF LOW C3/C4 LEVELS AND OTHER LABORATORY ASPECTS IN TURKISH CHILDREN WITH IMMUNOGLOBULIN A VASCULITIS

Yazarlar:

Şeyda Doğantan | Sema Nur Taşkın

Yayıncı:

Istanbul University

Ana Başlıklar:

Pediatric Rheumatology

Dergi:

Journal of Advanced Research in Health Sciences Vol.8 Issue 1, pp.47-52

Belge Tipi:

Makale

Yayın Tarihi:

4/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001344264

pISSN:

2651-4060

Anahtar kelimeler:

Özet:

 Objective: Immunoglobulin A vasculitis IgAV is the most prevalent systemic vasculitis in childhood. This intricate immune-mediated vasculitis affects the small blood vessels in several organ systems. Complements 3 and 4 C3 and C4 are constituents of the complement system; serum C3 C4 measurements play a Material and Methods: A total of 124 children60 IgAV patients and 64 healthy controlswere assessed in this study. The C3 and C4 levels were quantified using a turbidimetric immunoassays method with manufacturer details. The extractable nuclear antigen antibody ENA panels were evaluated using the ELISA method. The results were evaluated statistically. Results: The white blood cell count, neutrophil count, and neutrophil lymphocyte ratio were higher in the patient group compared to the control group p0.015, p0.013 and p0.039, respectively. CRP, ESR, and random urine proteincreatinine ratio RUPCR increased in patients than controls p0.001, p0.002 and p0.001 respectively. There was no difference in the lupus anticoagulant activity and low C3C4 levels between the groups p0.05. Conclusion: IgAV, an IgA-mediated systemic small vessel vasculitis, affects many organs. As a result, it is crucial to evaluate the laboratory results in the follow-up of the patient and the possible complications.

 Objective: Immunoglobulin A vasculitis IgAV is the most prevalent systemic vasculitis in childhood. This intricate immune-mediated vasculitis affects the small blood vessels in several organ systems. Complements 3 and 4 C3 and C4 are constituents of the complement system; serum C3 C4 measurements play a Material and Methods: A total of 124 children60 IgAV patients and 64 healthy controlswere assessed in this study. The C3 and C4 levels were quantified using a turbidimetric immunoassays method with manufacturer details. The extractable nuclear antigen antibody ENA panels were evaluated using the ELISA method. The results were evaluated statistically. Results: The white blood cell count, neutrophil count, and neutrophil lymphocyte ratio were higher in the patient group compared to the control group p0.015, p0.013 and p0.039, respectively. CRP, ESR, and random urine proteincreatinine ratio RUPCR increased in patients than controls p0.001, p0.002 and p0.001 respectively. There was no difference in the lupus anticoagulant activity and low C3C4 levels between the groups p0.05. Conclusion: IgAV, an IgA-mediated systemic small vessel vasculitis, affects many organs. As a result, it is crucial to evaluate the laboratory results in the follow-up of the patient and the possible complications.

 Objective: Immunoglobulin A vasculitis IgAV is the most prevalent systemic vasculitis in childhood. This intricate immune-mediated vasculitis affects the small blood vessels in several organ systems. Complements 3 and 4 C3 and C4 are constituents of the complement system; serum C3 C4 measurements play a Material and Methods: A total of 124 children60 IgAV patients and 64 healthy controlswere assessed in this study. The C3 and C4 levels were quantified using a turbidimetric immunoassays method with manufacturer details. The extractable nuclear antigen antibody ENA panels were evaluated using the ELISA method. The results were evaluated statistically. Results: The white blood cell count, neutrophil count, and neutrophil lymphocyte ratio were higher in the patient group compared to the control group p0.015, p0.013 and p0.039, respectively. CRP, ESR, and random urine proteincreatinine ratio RUPCR increased in patients than controls p0.001, p0.002 and p0.001 respectively. There was no difference in the lupus anticoagulant activity and low C3C4 levels between the groups p0.05. Conclusion: IgAV, an IgA-mediated systemic small vessel vasculitis, affects many organs. As a result, it is crucial to evaluate the laboratory results in the follow-up of the patient and the possible complications.

 Amaç: Eskiden Henoch-Schönlein purpurası olarak adlandırılan immünog lobulin A vasküliti IgAV, çocukluk çağında en sık görülen sistemik vaskülit türüdür. Kompleman 3 ve 4 C3 ve C4 kompleman sisteminin bileşenleri dir ve bazı bağışıklık hastalıklarıyla ilişkili oldukları bulunmuştur. Bu neden le bu çalışmada IgAVli çocuklarda düşük C3C4 düzeylerinin yanı sıra diğer laboratuvar bulgularını değerlendirmeyi amaçladık. Gereç ve Yöntemler: Bu çalışmada 60 IgAV hastası ve 64 sağlıklı kontrol olmak üzere toplam 124 çocuk değerlendirildi. C3 ve C4 düzeyleri, üretici ayrıntılarıyla birlikte türbidimetrik immünoanaliz yöntemi kullanılarak ölçüldü. Ekstrakte edilebilir nükleer antijen antikor ENA panelleri, enzime bağlı immünosorbent analizleri ELISA kullanılarak değerlendirildi. Sonuçlar istatistiksel olarak değerlendirildi. Bulgular: Hasta grubunda lökosit sayısı, nötrofil sayısı ve nötrofillenfosit oranı kontrol grubuna göre daha yüksek bulundu sırasıyla p0,015, p0,013 ve p0,039. Ayrıca hastalarda kontrollere göre CRP, ESR ve rastgele idrar proteinkreatinin oranı RUPCR artmış bulundu sırasıyla p0,001, p0,002 ve p0,001. Düşük C3C4 seviyeleri ve lupus antikoagülan aktivitesi açısından gruplar arasında anlamlı fark bulunamadı p0,05. Sonuç: IgA aracılı sistemik küçük damar vasküliti olan IgAV, öncelikle böbrekleri, eklemleri, gastrointestinal sistemi ve cildi etkilemektedir. Sonuç olarak, potansiyel hasta durumlarını izlerken laboratuvar sonuçlarının değerlendirilmesi çok önemlidir.

Makale detayları

A SINGLE CENTRE EXPERIENCE OF LOW C3/C4 LEVELS AND OTHER LABORATORY ASPECTS IN TURKISH CHILDREN WITH IMMUNOGLOBULIN A VASCULITIS

Yazarlar:

Şeyda Doğantan | Sema Nur Taşkın

Yayıncı:

Istanbul University

Ana Başlıklar:

Pediatric Rheumatology

Dergi:

Journal of Advanced Research in Health Sciences Vol.8 Issue 1, pp.47-52

Belge Tipi:

Makale

Yayın Tarihi:

4/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001344264

pISSN:

2651-4060

Immunoglobulin A vasculitis

C3

C4

immunoassayİmmünoglobulin A vasküliti

C3

C4

immünolojik test

Sayı

Makale detayları

Yazarlar: Şeyda Doğantan | Sema Nur Taşkın

Yayıncı: Istanbul University

Ana Başlıklar: Pediatric Rheumatology

Dergi: Journal of Advanced Research in Health Sciences Vol.8 Issue 1, pp.47-52

Belge Tipi: Makale

Yayın Tarihi: 4/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001344264

pISSN: 2651-4060

Sayı

Yazarlar:

Şeyda Doğantan | Sema Nur Taşkın

Yayıncı:

Istanbul University

Ana Başlıklar:

Pediatric Rheumatology

Dergi:

Journal of Advanced Research in Health Sciences Vol.8 Issue 1, pp.47-52

Belge Tipi:

Makale

Yayın Tarihi:

4/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001344264

pISSN:

2651-4060