The Inhibitory Effects of Resveratrol on Tumor Growth and Metastasis in Esophageal Adenocarcinoma

Saime Batırel; Bengü Çetinkaya; Ayşe Mine Yılmaz

Makale detayları

The Inhibitory Effects of Resveratrol on Tumor Growth and Metastasis in Esophageal Adenocarcinoma

Yazarlar:

Saime Batırel | Bengü Çetinkaya | Ayşe Mine Yılmaz

Yayıncı:

Marmara University

Ana Başlıklar:

Cancer Cell Biology

Dergi:

Clinical and Experimental Health Sciences Vol.15 Issue 3, pp.629-635

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001359610

pISSN:

2459-1459

Anahtar kelimeler:

Özet:

 Objective: Resveratrol is a small polyphenol that has been extensively researched across various therapeutic areas. Its inhibitory effect on esophageal cancer cell growth has also been demonstrated in a dose- and time-dependent manner. However, the underlying mechanism of this effect has not been fully elucidated yet. We aimed to investigate the anti-proliferative and anti-metastatic effects of resveratrol on esophageal adenocarcinoma EAC cells in vitro. Methods: The EAC cells were treated with various doses of resveratrol, and cell viability was determined using the WST-1 assay. The apoptosis rate and the level of intracellular reactive oxygen species ROS were measured using flow cytometry. Adhesion, wound healing, and colony formation assays were carried out to evaluate the anti-metastatic effects of resveratrol. Results: Resveratrol decreased the cell viability of OE33 cells in a dose-dependent manner. 150 µM resveratrol reduced cell viability by 49 compared to the control by increasing ROS levels. This inhibition was associated with the induction of apoptosis. The analysis revealed that resveratrol also suppressed the adhesion, migration, and colony forming capacity of the cells. Conclusion: Resveratrol lower the viability and metastatic potential of EAC cells. These findings suggest resveratrol may be further evaluated clinically for this malignancy in humans.

 Objective: Resveratrol is a small polyphenol that has been extensively researched across various therapeutic areas. Its inhibitory effect on esophageal cancer cell growth has also been demonstrated in a dose- and time-dependent manner. However, the underlying mechanism of this effect has not been fully elucidated yet. We aimed to investigate the anti-proliferative and anti-metastatic effects of resveratrol on esophageal adenocarcinoma EAC cells in vitro. Methods: The EAC cells were treated with various doses of resveratrol, and cell viability was determined using the WST-1 assay. The apoptosis rate and the level of intracellular reactive oxygen species ROS were measured using flow cytometry. Adhesion, wound healing, and colony formation assays were carried out to evaluate the anti-metastatic effects of resveratrol. Results: Resveratrol decreased the cell viability of OE33 cells in a dose-dependent manner. 150 µM resveratrol reduced cell viability by 49 compared to the control by increasing ROS levels. This inhibition was associated with the induction of apoptosis. The analysis revealed that resveratrol also suppressed the adhesion, migration, and colony forming capacity of the cells. Conclusion: Resveratrol lower the viability and metastatic potential of EAC cells. These findings suggest resveratrol may be further evaluated clinically for this malignancy in humans.

 Objective: Resveratrol is a small polyphenol that has been extensively researched across various therapeutic areas. Its inhibitory effect on esophageal cancer cell growth has also been demonstrated in a dose- and time-dependent manner. However, the underlying mechanism of this effect has not been fully elucidated yet. We aimed to investigate the anti-proliferative and anti-metastatic effects of resveratrol on esophageal adenocarcinoma EAC cells in vitro. Methods: The EAC cells were treated with various doses of resveratrol, and cell viability was determined using the WST-1 assay. The apoptosis rate and the level of intracellular reactive oxygen species ROS were measured using flow cytometry. Adhesion, wound healing, and colony formation assays were carried out to evaluate the anti-metastatic effects of resveratrol. Results: Resveratrol decreased the cell viability of OE33 cells in a dose-dependent manner. 150 µM resveratrol reduced cell viability by 49 compared to the control by increasing ROS levels. This inhibition was associated with the induction of apoptosis. The analysis revealed that resveratrol also suppressed the adhesion, migration, and colony forming capacity of the cells. Conclusion: Resveratrol lower the viability and metastatic potential of EAC cells. These findings suggest resveratrol may be further evaluated clinically for this malignancy in humans.

 Objective: Resveratrol is a small polyphenol that has been extensively researched across various therapeutic areas. Its inhibitory effect on esophageal cancer cell growth has also been demonstrated in a dose- and time-dependent manner. However, the underlying mechanism of this effect has not been fully elucidated yet. We aimed to investigate the anti-proliferative and anti-metastatic effects of resveratrol on esophageal adenocarcinoma EAC cells in vitro. Methods: The EAC cells were treated with various doses of resveratrol, and cell viability was determined using the WST-1 assay. The apoptosis rate and the level of intracellular reactive oxygen species ROS were measured using flow cytometry. Adhesion, wound healing, and colony formation assays were carried out to evaluate the anti-metastatic effects of resveratrol. Results: Resveratrol decreased the cell viability of OE33 cells in a dose-dependent manner. 150 µM resveratrol reduced cell viability by 49 compared to the control by increasing ROS levels. This inhibition was associated with the induction of apoptosis. The analysis revealed that resveratrol also suppressed the adhesion, migration, and colony forming capacity of the cells. Conclusion: Resveratrol lower the viability and metastatic potential of EAC cells. These findings suggest resveratrol may be further evaluated clinically for this malignancy in humans.

Makale detayları

The Inhibitory Effects of Resveratrol on Tumor Growth and Metastasis in Esophageal Adenocarcinoma

Yazarlar:

Saime Batırel | Bengü Çetinkaya | Ayşe Mine Yılmaz

Yayıncı:

Marmara University

Ana Başlıklar:

Cancer Cell Biology

Dergi:

Clinical and Experimental Health Sciences Vol.15 Issue 3, pp.629-635

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001359610

pISSN:

2459-1459

Resveratrol

Esophageal adenocarcinoma

anti-tumor

anti-metastatic

Sayı

Makale detayları

The Inhibitory Effects of Resveratrol on Tumor Growth and Metastasis in Esophageal Adenocarcinoma

Yazarlar: Saime Batırel | Bengü Çetinkaya | Ayşe Mine Yılmaz

Yayıncı: Marmara University

Ana Başlıklar: Cancer Cell Biology

Dergi: Clinical and Experimental Health Sciences Vol.15 Issue 3, pp.629-635

Belge Tipi: Makale

Yayın Tarihi: 9/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001359610

pISSN: 2459-1459

Resveratrol

Esophageal adenocarcinoma

anti-tumor

anti-metastatic

Sayı

Yazarlar:

Saime Batırel | Bengü Çetinkaya | Ayşe Mine Yılmaz

Yayıncı:

Marmara University

Ana Başlıklar:

Cancer Cell Biology

Dergi:

Clinical and Experimental Health Sciences Vol.15 Issue 3, pp.629-635

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001359610

pISSN:

2459-1459