Potential biomarkers for lung adenocarcinoma identified by integrative transcriptomics analysis

Ceyda KASAVİ

doi:https://doi.org/10.38042/biotechstudies.932937

Makale detayları

Potential biomarkers for lung adenocarcinoma identified by integrative transcriptomics analysis

Yazarlar:

Ceyda KASAVİ

Yayıncı:

Tarla Bitkileri Merkez Araştırma Enstitüsü

Ana Başlıklar:

İnsan psikolojisi

Dergi:

Biotech Studies 2021 Vol.30 Issue 1, pp.33-42

Belge Tipi:

Makale

Yayın Tarihi:

6/2021

Belge Dili:

İngilizce

Document ID (Org No.):

2000904904

Sıklık:

Aylık

eISSN:

2757-5233

pISSN:

2687-3761

DOI:

https://doi.org/10.38042/biotechstudies.932937

Özet:

 

Lung cancer is one of the most occurring and death-causing cancers worldwide. Despite the progress, survival rate is still low due to the late diagnosis. The aim of this study is to develop a computational framework to identify potential prognostic biomarkers for lung adenocarcinoma (LUAD). Gene expression profiles obtained from three independent studies were analyzed to find differentially expressed genes (DEGs) in LUAD. Disease-specific protein-protein interaction (PPI) network was constructed among common DEGs and hub proteins were identified. Gene expression data was integrated with the human transcriptional regulatory network (TRN) to identify key regulatory elements and construct disease-specific TRN. Hub proteins that were also present in TRN of LUAD were considered as potential biomarkers and assessed by survival analysis. AURKA, CAV1, CLU, ENO1, FHL1, FHL2, LMO2, MYH11, NME1 and SFN were discovered as biomarkers for LUAD and survival analysis not only indicated their significant prognostic performance as a group but also revealed their contribution to the discrimination of risk groups. Our findings suggested that identified biomarkers could be valuable in LUAD progression and they should be considered for further experimentation.

Makale detayları

Potential biomarkers for lung adenocarcinoma identified by integrative transcriptomics analysis

Yazarlar: Ceyda KASAVİ

Yayıncı: Tarla Bitkileri Merkez Araştırma Enstitüsü

Ana Başlıklar: İnsan psikolojisi

Dergi: Biotech Studies 2021 Vol.30 Issue 1, pp.33-42

Belge Tipi: Makale

Yayın Tarihi: 6/2021

Belge Dili: İngilizce

Document ID (Org No.): 2000904904

Sıklık: Aylık

eISSN: 2757-5233

pISSN: 2687-3761

DOI: https://doi.org/10.38042/biotechstudies.932937

Sayı

Yazarlar:

Ceyda KASAVİ

Yayıncı:

Tarla Bitkileri Merkez Araştırma Enstitüsü

Ana Başlıklar:

İnsan psikolojisi

Dergi:

Biotech Studies 2021 Vol.30 Issue 1, pp.33-42

Belge Tipi:

Makale

Yayın Tarihi:

6/2021

Belge Dili:

İngilizce

Document ID (Org No.):

2000904904

Sıklık:

Aylık

eISSN:

2757-5233

pISSN:

2687-3761

DOI:

https://doi.org/10.38042/biotechstudies.932937