The histopathological effects of calcium triglyceride bone cement and chitosan on the healing of experimental bone defects

Levent USLUCAN; Berkem ATALAY; Cüneyt Korhan ORAL; Mustafa Sami YILDIRIM; Abdülkadir Burak ÇANKAYA

Makale detayları

The histopathological effects of calcium triglyceride bone cement and chitosan on the healing of experimental bone defects

Yazarlar:

Levent USLUCAN | Berkem ATALAY | Cüneyt Korhan ORAL | Mustafa Sami YILDIRIM | Abdülkadir Burak ÇANKAYA

Yayıncı:

TUBITAK

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Turkish Journal of Medical Sciences 2018 Vol.48 Issue 6, pp.1268-1277

Belge Tipi:

Makale

Yayın Tarihi:

12/2018

Belge Dili:

İngilizce

Document ID (Org No.):

2000750493

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Özet:

 


                        Background/aim:
  This  study  evaluated  the  histopathological  effects  of  two  different  bone  grafts,  calcium  triglyceride  bone  cement  
(CTBC) and chitosan, on the healing of experimental bone defects. 
Materials and methods:
 Ninety-two Sprague Dawley male rats, with a weight of 240 ± 20 g, were used. Two experimental groups that 
consisted of 64 rats were divided into four subgroups due to the sacrification days, which were 7, 14, 30, and 60. After creating an 8-mm-
long and 1-mm-wide cortico-cancellous bone defect in the right tibia of each rat, CTBC and chitosan were applied to the bone defects. 
In the main group, after creating the bone defects in the right tibias, we kept those empty to serve as the control group. We evaluated 
inflammation, foreign body reaction, necrosis, fibrosis, new bone formation, and the residual graft material at 7, 14, 30, and 60 days. 
Results:
 In both the CTBC and chitosan groups, the new bone formation was higher than that in the control group, whereas foreign body 
reaction and residual graft material in the CTBC group and fibrosis in the chitosan group were significantly higher. After evaluating the 
results, both materials were found not to be very useful in the bone healing process. 
Conclusion:
 CTBC remained for a long time without being resorbed; it can be used as a placeholder in large bone defects, whereas the 
gel form of chitosan cannot be utilized for this purpose because it was resorbed in the first 7 days. 
                    

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Makale detayları

The histopathological effects of calcium triglyceride bone cement and chitosan on the healing of experimental bone defects

Yazarlar: Levent USLUCAN | Berkem ATALAY | Cüneyt Korhan ORAL | Mustafa Sami YILDIRIM | Abdülkadir Burak ÇANKAYA

Yayıncı: TUBITAK

Ana Başlıklar: Sağlık teşvikleri

Dergi: Turkish Journal of Medical Sciences 2018 Vol.48 Issue 6, pp.1268-1277

Belge Tipi: Makale

Yayın Tarihi: 12/2018

Belge Dili: İngilizce

Document ID (Org No.): 2000750493

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Sayı

Yazarlar:

Levent USLUCAN | Berkem ATALAY | Cüneyt Korhan ORAL | Mustafa Sami YILDIRIM | Abdülkadir Burak ÇANKAYA

Yayıncı:

TUBITAK

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Turkish Journal of Medical Sciences 2018 Vol.48 Issue 6, pp.1268-1277

Belge Tipi:

Makale

Yayın Tarihi:

12/2018

Belge Dili:

İngilizce

Document ID (Org No.):

2000750493

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144