Synthesis and Antinociceptive Activity of 2-[(2-Oxobenzothiazolin-3-yl)methyl]-5- aminoalkyl/aryl-1,3,4-thiadiazole

Tijen ÖNKOL; Bilge ÇAKIR; M. Fethi ŞAHİN

Makale detayları

Synthesis and Antinociceptive Activity of 2-[(2-Oxobenzothiazolin-3-yl)methyl]-5- aminoalkyl/aryl-1,3,4-thiadiazole

Yazarlar:

Tijen ÖNKOL | Bilge ÇAKIR | M. Fethi ŞAHİN

Yayıncı:

TUBITAK

Ana Başlıklar:

Uygulamalı fizik

Dergi:

Turkish Journal of Chemistry 2004 Vol.28 Issue 4, pp.461-468

Belge Tipi:

Makale

Yayın Tarihi:

3/2004

Belge Dili:

İngilizce

Document ID (Org No.):

2000729296

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

Özet:

 

Ten 2-[(2-oxobenzothiazolin-3-yl)methyl]-5-aminoalkyl/aryl-1,3,4-thiadiazole  derivatives were synthesized.  The chemical structures of these  compounds were elucidated by their FT-IR and 1H-NMR spectral data, as  well as their elemental analyses.  The compounds were tested for  antinociceptive activity.  Among these compounds,  2-[(2-oxobenzothiazolin-3-yl)methyl]-5-aminomethyl-1,3,4-thiadiazole  (5a) was found to be significantly more active than the others and the  standards in all the tests.

 

Ten 2-[(2-oxobenzothiazolin-3-yl)methyl]-5-aminoalkyl/aryl-1,3,4-thiadiazole  derivatives were synthesized.  The chemical structures of these  compounds were elucidated by their FT-IR and 1H-NMR spectral data, as  well as their elemental analyses.  The compounds were tested for  antinociceptive activity.  Among these compounds,  2-[(2-oxobenzothiazolin-3-yl)methyl]-5-aminomethyl-1,3,4-thiadiazole  (5a) was found to be significantly more active than the others and the  standards in all the tests.

Makale detayları

Synthesis and Antinociceptive Activity of 2-[(2-Oxobenzothiazolin-3-yl)methyl]-5- aminoalkyl/aryl-1,3,4-thiadiazole

Yazarlar: Tijen ÖNKOL | Bilge ÇAKIR | M. Fethi ŞAHİN

Yayıncı: TUBITAK

Ana Başlıklar: Uygulamalı fizik

Dergi: Turkish Journal of Chemistry 2004 Vol.28 Issue 4, pp.461-468

Belge Tipi: Makale

Yayın Tarihi: 3/2004

Belge Dili: İngilizce

Document ID (Org No.): 2000729296

Sıklık: İki Aylık

eISSN: 1303-6130

pISSN: 1300-0527

Sayı

Yazarlar:

Tijen ÖNKOL | Bilge ÇAKIR | M. Fethi ŞAHİN

Yayıncı:

TUBITAK

Ana Başlıklar:

Uygulamalı fizik

Dergi:

Turkish Journal of Chemistry 2004 Vol.28 Issue 4, pp.461-468

Belge Tipi:

Makale

Yayın Tarihi:

3/2004

Belge Dili:

İngilizce

Document ID (Org No.):

2000729296

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527