An efficient one-pot, three-component synthesis of 6-cyano-hexahydro-4H -thieno[3’,2’:5,6]pyrimido[1,2-a]quinoline-2-carboxylates and their spiro derivatives from β -enaminones

Said Ahmed Soliman GHOZLAN; Doaa Mohmed ABDELMONIEM; Amr Mohmed ABDELMONIEM; İsmail Abdelshafy ABDELHAMID

Makale detayları

An efficient one-pot, three-component synthesis of 6-cyano-hexahydro-4H -thieno[3’,2’:5,6]pyrimido[1,2-a]quinoline-2-carboxylates and their spiro derivatives from β -enaminones

Yazarlar:

Said Ahmed Soliman GHOZLAN | Doaa Mohmed ABDELMONIEM | Amr Mohmed ABDELMONIEM | İsmail Abdelshafy ABDELHAMID

Yayıncı:

TUBITAK

Ana Başlıklar:

Uygulamalı fizik

Dergi:

Turkish Journal of Chemistry 2016 Vol.40 Issue 3, pp.434-440

Belge Tipi:

Makale

Yayın Tarihi:

5/2016

Belge Dili:

İngilizce

Document ID (Org No.):

2000726615

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

Özet:

 

A simple and efficient one-pot synthesis of novel   thieno[3',2':5,6]pyrimido[1,2-a]quinoline-2-carboxylates   (5a-d) and their spirooxindole derivatives   (12a-d) was accomplished. Thus, the Michael addition   reaction of the cyclic ββ\beta -enaminone 3 with the corresponding  α,βα,β\alpha ,\beta -unsaturated nitrile derivatives 4a-d in   refluxing EtOH in the presence of piperidine afforded   5a-d in good yields. On the other hand, spirooxindole   derivatives 12a-d were synthesized by the reaction of   cyclic ββ\beta -enaminone 3 with the corresponding   3-cyanomethylidene-2-oxoindoles 11a-d in refluxing EtOH.

Makale detayları

An efficient one-pot, three-component synthesis of 6-cyano-hexahydro-4H -thieno[3’,2’:5,6]pyrimido[1,2-a]quinoline-2-carboxylates and their spiro derivatives from β -enaminones

Yazarlar: Said Ahmed Soliman GHOZLAN | Doaa Mohmed ABDELMONIEM | Amr Mohmed ABDELMONIEM | İsmail Abdelshafy ABDELHAMID

Yayıncı: TUBITAK

Ana Başlıklar: Uygulamalı fizik

Dergi: Turkish Journal of Chemistry 2016 Vol.40 Issue 3, pp.434-440

Belge Tipi: Makale

Yayın Tarihi: 5/2016

Belge Dili: İngilizce

Document ID (Org No.): 2000726615

Sıklık: İki Aylık

eISSN: 1303-6130

pISSN: 1300-0527

Sayı

Yazarlar:

Said Ahmed Soliman GHOZLAN | Doaa Mohmed ABDELMONIEM | Amr Mohmed ABDELMONIEM | İsmail Abdelshafy ABDELHAMID

Yayıncı:

TUBITAK

Ana Başlıklar:

Uygulamalı fizik

Dergi:

Turkish Journal of Chemistry 2016 Vol.40 Issue 3, pp.434-440

Belge Tipi:

Makale

Yayın Tarihi:

5/2016

Belge Dili:

İngilizce

Document ID (Org No.):

2000726615

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527