Synthesis, Characterization and Antimicrobial Activity of Mixed-Ligand Metal Complexes of 4,4'-Bipyridine and Aniline-2,5-Disulfonic Acid

Nurgün Büyükkıdan; Seher Kaya; Halil İlkimen; Aysel Gülbandılar

Makale detayları

Synthesis, Characterization and Antimicrobial Activity of Mixed-Ligand Metal Complexes of 4,4'-Bipyridine and Aniline-2,5-Disulfonic Acid

Yazarlar:

Nurgün Büyükkıdan | Seher Kaya | Halil İlkimen | Aysel Gülbandılar

Yayıncı:

Bayburt University

Ana Başlıklar:

Kimya Mühendisliği (Diğer)

Dergi:

Bayburt Üniversitesi Fen Bilimleri Dergisi Vol.7 Issue 2, pp.67-78

Belge Tipi:

Makale

Yayın Tarihi:

12/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001337017

pISSN:

2667-579X

Anahtar kelimeler:

Özet:

 In this study, we prepared mixed-ligand CoII complexCoADSABPn.2H2O, 1, NiII complex NiADSABPn, 2, and ZnII complex ZnADSABPH2O2n.3H2O, 3 of 4,4-bipyridine BP with aniline-2,5-disulfonic acid H2ADSA. The 1-3 were characterized by elemental analysis, AAS, TGA, IR, UV-Vis, molar conductivity and magnetic susceptibility techniques. Furthermore, the microdilution method was used to explore the antibacterial and antifungal activities of the initial and the synthesized metal complexes against the following bacteria and yeast: Pseudomonas aeruginosa, Escherichia coli, Enterococcus faecalis, Listeria monocytogenes, Staphylococcus aureus, Bacillus subtilis and Candida albicans. Antibacterial and antifungal activity results were compared with antibiotics Vancomycin, Levofloxacin, Cefepime, Chloramphenicol, Fluconazole and Ketoconazole. Through the examination of the conducted studies, it was noted that the recently created compounds demonstrated efficacy in combating both bacterial and yeast infections.

 In this study, we prepared mixed-ligand CoII complexCoADSABPn.2H2O, 1, NiII complex NiADSABPn, 2, and ZnII complex ZnADSABPH2O2n.3H2O, 3 of 4,4-bipyridine BP with aniline-2,5-disulfonic acid H2ADSA. The 1-3 were characterized by elemental analysis, AAS, TGA, IR, UV-Vis, molar conductivity and magnetic susceptibility techniques. Furthermore, the microdilution method was used to explore the antibacterial and antifungal activities of the initial and the synthesized metal complexes against the following bacteria and yeast: Pseudomonas aeruginosa, Escherichia coli, Enterococcus faecalis, Listeria monocytogenes, Staphylococcus aureus, Bacillus subtilis and Candida albicans. Antibacterial and antifungal activity results were compared with antibiotics Vancomycin, Levofloxacin, Cefepime, Chloramphenicol, Fluconazole and Ketoconazole. Through the examination of the conducted studies, it was noted that the recently created compounds demonstrated efficacy in combating both bacterial and yeast infections.

 In this study, we prepared mixed-ligand CoII complexCoADSABPn.2H2O, 1, NiII complex NiADSABPn, 2, and ZnII complex ZnADSABPH2O2n.3H2O, 3 of 4,4-bipyridine BP with aniline-2,5-disulfonic acid H2ADSA. The 1-3 were characterized by elemental analysis, AAS, TGA, IR, UV-Vis, molar conductivity and magnetic susceptibility techniques. Furthermore, the microdilution method was used to explore the antibacterial and antifungal activities of the initial and the synthesized metal complexes against the following bacteria and yeast: Pseudomonas aeruginosa, Escherichia coli, Enterococcus faecalis, Listeria monocytogenes, Staphylococcus aureus, Bacillus subtilis and Candida albicans. Antibacterial and antifungal activity results were compared with antibiotics Vancomycin, Levofloxacin, Cefepime, Chloramphenicol, Fluconazole and Ketoconazole. Through the examination of the conducted studies, it was noted that the recently created compounds demonstrated efficacy in combating both bacterial and yeast infections.

 Bu çalışmada 4,4-bipiridin BP ve anilin-2,5-disülfonik asit H2ADSA ile karışık ligandlı CoII CoADSABPn.2H2O, 1, NiII NiADSABPn, 2 ve ZnII ZnADSABPH2O2n.3H2O, 3 kompleksleri hazırladı. 1-3 Element analizi, AAS, TGA, IR, UV-Vis, molar iletkenlik ve manyetik duyarlılık teknikleri ile karakterize edildi. Ayrıca mikrodilüsyon yöntemi ile başlangıç maddeleri ve sentezlenen metal komplekslerinin aşağıdaki bakteriler ve mayaya karşı antibakteriyel ve antifungal aktivitelerini araştırmak için kullanıldı: Pseudomonas aeruginosa, Escherichia coli, Enterococcus faecalis, Listeria monocytogenes, Staphylococcus aureus, Bacillus subtilis ve Candida albicans. Antibakteriyel ve antifungal aktivite sonuçları antibiyotiklerle Vankomisin, Levofloksasin, Sefepim, Kloramfenikol, Flukonazol ve Ketokonazol karşılaştırıldı. Yapılan çalışmalar incelendiğinde, yeni oluşturulan bileşiklerin hem bakteri hem de maya enfeksiyonlarıyla mücadelede aktivite gösterdiği gözlenmiştir.

Makale detayları

Synthesis, Characterization and Antimicrobial Activity of Mixed-Ligand Metal Complexes of 4,4'-Bipyridine and Aniline-2,5-Disulfonic Acid

Yazarlar:

Nurgün Büyükkıdan | Seher Kaya | Halil İlkimen | Aysel Gülbandılar

Yayıncı:

Bayburt University

Ana Başlıklar:

Kimya Mühendisliği (Diğer)

Dergi:

Bayburt Üniversitesi Fen Bilimleri Dergisi Vol.7 Issue 2, pp.67-78

Belge Tipi:

Makale

Yayın Tarihi:

12/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001337017

pISSN:

2667-579X

4,4'-Bipyridine

Aniline-2,5-disulfonic acid

Metal complex

Antimicrobial activity4,4'-Bipiridin

anilin-2,5-disülfonik asit

Metal kompleksi

Antimikrobiyal aktivite

Sayı

Makale detayları

Yazarlar: Nurgün Büyükkıdan | Seher Kaya | Halil İlkimen | Aysel Gülbandılar

Yayıncı: Bayburt University

Ana Başlıklar: Kimya Mühendisliği (Diğer)

Dergi: Bayburt Üniversitesi Fen Bilimleri Dergisi Vol.7 Issue 2, pp.67-78

Belge Tipi: Makale

Yayın Tarihi: 12/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001337017

pISSN: 2667-579X

Sayı

Yazarlar:

Nurgün Büyükkıdan | Seher Kaya | Halil İlkimen | Aysel Gülbandılar

Yayıncı:

Bayburt University

Ana Başlıklar:

Kimya Mühendisliği (Diğer)

Dergi:

Bayburt Üniversitesi Fen Bilimleri Dergisi Vol.7 Issue 2, pp.67-78

Belge Tipi:

Makale

Yayın Tarihi:

12/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001337017

pISSN:

2667-579X