O-Galloyl Flavonoids from Geranium pyrenaicum and Their in vitro Antileishmanial Activity

Dilek ERCİL; Maeki KALOGA; Oliver A. RADTKE; M. Koray SAKAR; Albrecht F. KIDERLEN; Herbert KOLODZIEJ

Makale detayları

O-Galloyl Flavonoids from Geranium pyrenaicum and Their in vitro Antileishmanial Activity

Yazarlar:

Dilek ERCİL | Maeki KALOGA | Oliver A. RADTKE | M. Koray SAKAR | Albrecht F. KIDERLEN | Herbert KOLODZIEJ

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2005 Vol.29 Issue 4, pp.437-443

Belge Tipi:

Makale

Yayın Tarihi:

3/2005

Belge Dili:

Türkçe

Document ID (Org No.):

2000729083

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

Özet:

 

From the aerial parts of Geranium pyrenaicum Burm., a new  flavonol glycoside, kaempferol  3-O-(2'',3''-di-O-galloyl)-{\ss}-D-glucopyranoside (7), along with 6  known related glycosides [kaempferol 3-O-b-D-glucopyranoside (1),  quercetin 3-O-b-D-glucopyranoside (2), quercetin  3-O-b-D-galactopyranoside (3), kaempferol  3-O-(2''-O-galloyl)-b-D-glucopyranoside (4), quercetin  3-O-(2''-O-galloyl)-b-D-glucopyranoside (5) and quercetin  3-O-(2'',3''-di-O-galloyl)-{\ss}-D-glucopyranoside (6)] and the  ellagitannins corilagin (8) and tellimagrandin I (9) were isolated.   Their structures were established from spectroscopic studies (UV,  FAB-MS, 1H and 13C-NMR, 1H-1H COSY, HETCOR, HMBC).  Compounds  1-7 were evaluated for antileishmanial activity against a panel of  Leishmania species (L. major, L. donovani and L. amazonensis),  indicating appreciable in vitro activities (IC50 4-27 nM) when  compared with Pentostam (IC50 10-11 nM).

 

From the aerial parts of Geranium pyrenaicum Burm., a new  flavonol glycoside, kaempferol  3-O-(2'',3''-di-O-galloyl)-{\ss}-D-glucopyranoside (7), along with 6  known related glycosides [kaempferol 3-O-b-D-glucopyranoside (1),  quercetin 3-O-b-D-glucopyranoside (2), quercetin  3-O-b-D-galactopyranoside (3), kaempferol  3-O-(2''-O-galloyl)-b-D-glucopyranoside (4), quercetin  3-O-(2''-O-galloyl)-b-D-glucopyranoside (5) and quercetin  3-O-(2'',3''-di-O-galloyl)-{\ss}-D-glucopyranoside (6)] and the  ellagitannins corilagin (8) and tellimagrandin I (9) were isolated.   Their structures were established from spectroscopic studies (UV,  FAB-MS, 1H and 13C-NMR, 1H-1H COSY, HETCOR, HMBC).  Compounds  1-7 were evaluated for antileishmanial activity against a panel of  Leishmania species (L. major, L. donovani and L. amazonensis),  indicating appreciable in vitro activities (IC50 4-27 nM) when  compared with Pentostam (IC50 10-11 nM).

Makale detayları

O-Galloyl Flavonoids from Geranium pyrenaicum and Their in vitro Antileishmanial Activity

Yazarlar: Dilek ERCİL | Maeki KALOGA | Oliver A. RADTKE | M. Koray SAKAR | Albrecht F. KIDERLEN | Herbert KOLODZIEJ

Yayıncı: TUBITAK

Dergi: Turkish Journal of Chemistry 2005 Vol.29 Issue 4, pp.437-443

Belge Tipi: Makale

Yayın Tarihi: 3/2005

Belge Dili: Türkçe

Document ID (Org No.): 2000729083

Sıklık: İki Aylık

eISSN: 1303-6130

pISSN: 1300-0527

Sayı

Yazarlar:

Dilek ERCİL | Maeki KALOGA | Oliver A. RADTKE | M. Koray SAKAR | Albrecht F. KIDERLEN | Herbert KOLODZIEJ

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2005 Vol.29 Issue 4, pp.437-443

Belge Tipi:

Makale

Yayın Tarihi:

3/2005

Belge Dili:

Türkçe

Document ID (Org No.):

2000729083

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527