In Vitro Evaluation of Gilaburu (Viburnum Opulus L. ) Juice on Different Cell Lines

Ayşe Tansu KOPARAL

doi:https://doi.org/10.18039/ajesi.577253

Makale detayları

In Vitro Evaluation of Gilaburu (Viburnum Opulus L. ) Juice on Different Cell Lines

Yazarlar:

Ayşe Tansu KOPARAL

Yayıncı:

Anadolu University

Ana Başlıklar:

Sosyoloji & antropoloji

Dergi:

Anadolu Journal of Educational Sciences International 2019 Vol.9 Issue 2, pp.549-571

Belge Tipi:

Makale

Yayın Tarihi:

6/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000863835

Sıklık:

İki Yıllık

eISSN:

2146-4014

pISSN:

2146-4014

DOI:

https://doi.org/10.18039/ajesi.577253

Özet:

 


The purpose of this
study is to investigate the effects of gilaburu juice on cell viability
(3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyl tetrazolium bromide, MTT) and
angiogenesis (tube formation assay) using different cell lines (human cancer
cell lines A549, Caco-2, HeLa and normal cell lines MDCK and HUVEC) in vitro.
In addition, the genotoxic effects of gilaburu juice is evaluated using COMET
assay on HUVEC cells. Our results demonstrate that gilaburu juice could inhibit
the growth of Caco-2 and HeLa cancer cell lines, but could not significantly
inhibit normal cell lines and A549 cancer cell lines. It disrupted tube
formation of HUVEC cells. Gilaburu juice appears to have no genotoxic potential
to the DNA of HUVEC cells. The results obtained in this study confirm the
potential application of commercial gilaburu juice as a functional food in
prevention of cancer.


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Makale detayları

In Vitro Evaluation of Gilaburu (Viburnum Opulus L. ) Juice on Different Cell Lines

Yazarlar: Ayşe Tansu KOPARAL

Yayıncı: Anadolu University

Ana Başlıklar: Sosyoloji & antropoloji

Dergi: Anadolu Journal of Educational Sciences International 2019 Vol.9 Issue 2, pp.549-571

Belge Tipi: Makale

Yayın Tarihi: 6/2019

Belge Dili: İngilizce

Document ID (Org No.): 2000863835

Sıklık: İki Yıllık

eISSN: 2146-4014

pISSN: 2146-4014

DOI: https://doi.org/10.18039/ajesi.577253

Sayı

Yazarlar:

Ayşe Tansu KOPARAL

Yayıncı:

Anadolu University

Ana Başlıklar:

Sosyoloji & antropoloji

Dergi:

Anadolu Journal of Educational Sciences International 2019 Vol.9 Issue 2, pp.549-571

Belge Tipi:

Makale

Yayın Tarihi:

6/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000863835

Sıklık:

İki Yıllık

eISSN:

2146-4014

pISSN:

2146-4014

DOI:

https://doi.org/10.18039/ajesi.577253